Т.N. Savchenko - Dr. Sc. (Med.), Professor, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: 12111944t@mail.ru L.A. Shcheplyagina - Dr. Sc. (Med.), Professor, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology, Ministry of Public Health and Social Development of the Russian Federation, Moscow. E-mail: cheply@mail.ru Y.E. Dobrochotova - Dr. Sc. (Med.), Professor, Head of Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: rsmu@rsmu.ru T.A. Osipova  Head of Laboratory, Research Center «EFiS», Moscow. E-mail: Osipova@efis.ru I.A. Dergacheva - Post-graduate Student, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: Ira_ignatenko@mail.ru M.I. Agaeva - Post-graduate Student, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: Madlen1690@mail.ru