Т.N. Savchenko - Dr. Sc. (Med.), Professor, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: 12111944t@mail.ru L.A. Shcheplyagina - Dr. Sc. (Med.), Professor, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology, Ministry of Public Health and Social Development of the Russian Federation, Moscow. E-mail: cheply@mail.ru Y.E. Dobrochotova - Dr. Sc. (Med.), Professor, Head of Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: rsmu@rsmu.ru T.A. Osipova  Head of Laboratory, Research Center «EFiS», Moscow. E-mail: Osipova@efis.ru I.A. Dergacheva - Post-graduate Student, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: Ira_ignatenko@mail.ru M.I. Agaeva - Post-graduate Student, Department of Obstetrics and Gynecology of Medical Faculty, N.I. Pirogov Russian National Research Medical University, Moscow. E-mail: Madlen1690@mail.ru

Over the past decades have seen the role of vitamin D deficiency in the development and persistence of infectious agents, and its impact on the various parts of the immune response. The objective. To analyze the security of vitamin D women with physiological course of gestation and with miscarriage of infectious genesis, to determine the link between vitamin D levels and the level of cytokines in the blood of pregnant women. Materials and methods. The study involved 50 pregnant women in the winter-spring period. Of these, 25 women with normal pregnancy, 15 women with threatened miscarriage and 10 women to terminate a pregnancy. All pregnant were diagnosed of urogenital infection, immunity indices with measurement of cytokines in the blood serum. The concentration of 25 (OH) D\'3 in the blood plasma was determined for all pregnant women. Results and discussion. According to the results of the study found that the value of vitamin D levels below 20 ng / ml often accompanied by miscarriage. Correlation analysis confirmed the relationship between cytokine production and the level of vitamin D in the blood of pregnant women. Conclusion. Normalization of vitamin D levels in the blood may help prevent miscarriage.

 

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