Н.А. Олейникова1, Н.Б. Бабунашвили2, О.Ю. Нестерова3, Н.В. Данилова4, О.А. Харлова5, Д.А. Охоботов6, П.Г. Мальков7, А.А. Камалов8

1,3–8 Медицинский научно-образовательный центр МГУ им. М.В. Ломоносова (Москва, Россия)
2,8 МГУ им. М.В. Ломоносова (Москва, Россия)

Постановка проблемы. Опухоль-ассоциированные фибробласты (CAFs) – клетки неэпителиального происхождения, наиболее широко представленные в строме опухоли. В последние годы получены доказательства их исключительной роли в прогрессии заболевания. Имеющиеся различия в экспрессии молекул CAFs в опухолях, поражающих те или иные органы, побуждают подробнее изучить их свойства в раке предстательной железы (РПЖ).

Цель работы – выявление маркеров CAFs, наиболее значимых для диагностики РПЖ и определения его стадии, на основании данных современной литературы.

Результаты. В ходе анализа новейших данных о CAFs был сформирован список маркеров, применяемых в диагностике РПЖ, описаны наиболее перспективные из них, критически оценена специфичность и значимость некоторых молекул, прежде рассматриваемых в качестве классических маркеров.

Практическая значимость. Представленные в работе маркеры могут быть использованы в диагностике РПЖ и рассмотрены в качестве таргетных молекул для медикаментозной терапии.

Олейникова Н.А., Бабунашвили Н.Б., Нестерова О.Ю., Данилова Н.В., Харлова О.А., Охоботов Д.А., Мальков П.Г., Камалов А.А. Опухоль-ассоциированные фибробласты при раке предстательной железы // Технологии живых систем. 2022. T. 19. № 4.
С. 5-23. DOI: https://doi.org/10.18127/j20700997-202204-01

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