К.Д. Рысенкова, Е.В. Сёмина, М.Н. Карагяур,

А.А. Шмакова, Д.Т. Дыйканов, К.А. Рубина,

В.А. Ткачук

Проведен подбор последовательностей направляющих РНК для подавле-

ния экспрессии гена урокиназного рецептора (PLAUR) в клетках нейро-

бластомы Neuro2a с помощью технологии редактирования генома

CRISPR/Cas9. Обнаружено, что снижение экспрессии PLAUR подавляет

инвазивный потенциал нейробластомы, который в норме стимулируется

урокиназой – эндогенным лигандом урокиназного рецептора.

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