350 руб
Журнал «Технологии живых систем» №2 за 2015 г.
Статья в номере:
Система инсулиноподобных факторов роста. Ч. 1. Биосинтез, сигнальные пути регуляции в норме и при злокачественной трансформации
Ключевые слова: инсулиноподобный фактор роста IGF-I IGF-II IGFBP IGF-R канцерогенез
Авторы:
Юрий Сергеевич Тимофеев - врач клинической лабораторной диагностики, лаборатория клинической биохимии, ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» (Москва). E-mail: timo-feev_lab@mail.ru Ульви Рафаил оглы Мамедов - к.м.н., ст.науч.сотрудник, отделение опухолей молочных желез, ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» Светлана Владимировна Муштенко - аспирант, кафедра онкологии, Московский медико-стоматологический университет им. А.И. Евдокимова МЗ РФ Александр Владимирович Масляев - врач-онколог, отделение радиохирургии, ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» Игорь Константинович Воротников - д.м.н., профессор, зав. отделением опухолей молочных желез, ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» Елена Сергеевна Герштейн - д.б.н., профессор, лаборатория клинической биохимии, ФГБНУ «Российский онкологический на-учный центр им. Н.Н. Блохина»
Аннотация:
Представлена подробная характеристика системы инсулиноподобных факторов роста (система IGF). Описаны молекулярные особенности ее лигандов, рецепторов, регуляторных белков, механизмы их взаимодействия, а также влияние на другие внутриклеточные сигнальные системы. Приведены данные о связи указанной клеточной системы с развитием злокачественных опухолей, ее роли в процессах пролиферации опухолевых клеток, роста опухоли, в ангиогенезе, а также процессах инвазии и метастазирования.
Страницы: 36-55
Список источников

 

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