350 руб
Журнал «Технологии живых систем» №3 за 2013 г.
Статья в номере:
Современная гистологическая классификация нэйроэндокринных опухолей: диагностическое и прогностическое значение
Ключевые слова: нейроэндокринная опухоль желудочно-кишечный тракт поджелудочная железа бронхопульмональная система дифференцировка степень злокачественности
Авторы:
В.В. Делекторская - д.м.н., зав. лабораторией гистохимии электронной микроскопии и иммуногистохимии, ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН (Москва). E-mail: delektorskaya@yandex.ru
Аннотация:
Проанализированы современные представления о наиболее распространенных и отдельных редких формах нейроэндокринных новообразований человека. Обобщены сведения об особенностях последних гистологических классификаций опухолей пищеварительной и бронхопульмональной систем, а также представлены данные о гистогенезе и критериях морфологической диагностики нейроэндокринных новообразований. Проанализированы наиболее важные нозологические формы опухолей данного типа.
Страницы: 3-20
Список источников
  1. AsamuraH.,KameyaT., MatsunoY.etal.Neuroendocrineneoplasmsofthelung: aprognosticspectrum // J. Clin.Oncol.2006. № 24.P.70?76.
  2. Aslan D.L., Gulbahce H.E., Pambuccian S.E. et al.Ki-67 immunoreactivity in the differential diagnosis of pulmonary neuroendocrine neoplasms in specimens with extensive crush artifact // Am. J. Clin. Pathol. 2005. V. 123. № 6. P. 874 - 878.
  3. Bedini A.V., Andreani S.M., Tavecchio L. et al.Proposal of a novel system for the staging of thymic epithelial tumors // Ann. Thorac. Surg. 2005. V. 8. № 6. P. 1994 - 2000.
  4. Bosman F.T., Carneiro F.T., Hrubon R.H. et al. (Eds) World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of the Digestive System // IARC Press: Lyon. France. 2010.
  5. Caplin M., Yao J.C. An overview of thoracic and gastrointestinal  neuroendocrine tumours // In: Caplin M., Yao J.C. (eds). Handbook of Gastroenteropancreatic and Thoracic Neuroendocrine Tumours. BioScientifica. 2011. P. 1 - 9.
  6. Costes V., Marty-Ane C., Picot M.C. et al.Typical and atypical bronchopulmonary carcinoid tumors: a clinicopathologic and Ki-67-labeling study // Hum. Pathol. 1995. V. 26. P. 740 - 745.
  7. DeLellis R.A., Shin S.J., Treaba O.D. Chapter 10: Immunohistology of Endocrine Tumors // In: Dabbs D.J. ed. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. 3rdEdition. Elsevier Inc. 2010. P. 291 - 329
  8. Dhall D., Mertens R., Bresee C. et al. Ki-67 proliferative index predicts progression-free survival of patients with well-differentiated ileal neuroendocrine tumors // Hum. Pathol.2012. V. 43. № 4. P. 489 ? 495.
  9. Du E.Z., Goldstraw P., Zacharias J.et al.TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location // Hum. Pathol. 2004. V. 35. № 7. P. 825 - 831.
  10. Dutta R., Kumar A., Julka P.K. et al. Thymic neuroendocrine tumour (carcinoid): clinicopathological features of four patients with different presentation // Interact. Cardiovasc. Thorac. Surg. 2010. V. 11. P. 732 - 736.
  11. Gal A.A., Kornstein M.J., Cohen C. et al.Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study // Ann. Thorac. Surg. 2001. V. 7. № 4. P. 1179 - 1182.
  12. Goldstraw P. IASLC Staging Manual in Thoracic Oncology // 1st edn. International Association for the Study of Lung Cancer. Editorial Rx Press. Orange Park. FL. 2009.
  13. Gosney J., Travis W.D.Tumours of the lung // In: Travis W., Brambilla E., Müller-Hermelink H., Harris C. eds. World Health Organization Classification of tumours. Pathology and genetics: tumours of the lung, pleura, thymus and heart. Lyon. France: IARC. 2004. P. 76 - 77.
  14. Gustafsson B.I., Kidd M., Chan A. et al.Bronchopulmonary neuroendocrine tumors // Cancer. 2008. V. 113. № 1. P. 5 - 21.
  15. Jamali M., Chetty R. Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining // Endocr. Pathol.2008. V. 19. № 4. P. 282 - 288.
  16. Kalhor N., Moran C.A. Mediastinal neuroendocrine tumours // Diagnostic Histopathology. 2010. V. 16. № 5. P. 237 - 242.
  17. Kaufmann O., Dietel M.Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites // Histopathology. 2000. V. 36. № 5. P. 415 - 420.
  18. Klimstra D.S., Modlin I.R., Adsay N.V. et al. Pathology Reporting of Neuroendocrine Tumors: Application of the Delphic Consensus Process to the Development of a Minimum Pathology Data Set // Am. J. Surg. Pathol. 2010. V. 34. № 3. R. 300 - 313.
  19. Klöppel G., Perren A., Heitz P.U.The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification // Ann. N. Y. Acad. Sci. 2004. V. 1014. P. 13 - 27.
  20. Klöppel G. Tumour biology and histopathology of neuroendocrine tumours // Best Practice Research Clinical Endocrin Metabolism. 2007. V. 21. № 1.
    P. 15 - 31.
  21. Klöppel G.Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms // Endocr.Relat. Cancer. 2011. V. 18. P. S1 - S16.
  22. KultschizkyN.ZurFrage über denBaudesDarmkanals // Archiv für mikroscopische Anatomie und Entwickelungsgeschichte. 1897. V. 49. P. 7-35.
  23. Kobayashi Y., Tokuchi Y., Hashimoto T. et al.Molecular markers for reinforcement of histological subclassification of neuroendocrine lung tumors // Cancer Sci. 2004. V. 95. № 4. P. 334 - 341.
  24. Koga K., Matsuno Y., Noguchi M. et al. A review of 79 thymomas: modification of staging system and reappraisal of conventional division into invasive and noninvasive thymoma // Pathol. Int. 1994.
    V. 44. № 5. P. 359 - 367.
  25. Kontogianni K., Nicholson A.G., Butcher D. et al. CD56: a useful tool for the diagnosis of small cell lung carcinomas on biopsies with extensive crush artefact // J. Clin. Pathol. 2005. V. 58. P. 978 - 980.
  26. Koutsami M.K., Doussis-Anagnostopoulou I., Papavassiliou A.G., Gorgoulis V.G. Genetic and molecular coordinates of neuroendocrine lung tumors, with emphasis on small-cell lung carcinomas // Mol. Med.2002. V. 8. № 8. P. 419 - 436.
  27. Krishna M.Diagnosis of metastatic neoplasms: an immunohistochemical approach // Arch. Patho. Lab. Med. 2010. V. 134. № 2. P. 207 - 215.
  28. Luh S.P., Kuo C., Liu W.S., Wu T.C., Koo C.L., Chen J.Y.Carcinoid tumor of the thymus: a clinicopathologic report of two cases with a review of the literature // Int. Surg. 2005. V. 90. P. 270 - 274.
  29. Marchevsky A.M., Gupta R., Balzer B.Diagnosis of metastatic neoplasms: a clinicopathologic and morphologic approach // Arch. Pathol. Lab. Med. 2010. V. 134. № 2. P. 194 - 206.
  30. Marx A., Strobel P., Zettl A. et al.Tumours of the thymus. // In: Travis W., Brambilla E., Müller-HermelinkH.K., Harris C.C. eds. World Health Organization Classification of tumours. Pathology and genetics: tumours of the lung, pleura, thymus and heart. Lyon: IARC. 2004. P. 93 - 145.
  31. Masaoka A., Monden Y., Nakahara K., Tanioka T. Follow-up study of thymomas with special reference to their clinical stages // Cancer. 1981. V. 48. № 11. P. 2485 - 2492.
  32. Mertz H., Vyberg M., Paulsen S.M., Teglbjærg P.S.Immunohistochemical detection of neuroendocrine markers in tumors of the lungsandgastrointestinaltract // Appl.Immunohistochem. 1998. V. 6. P. 175 -180.
  33. Modlin I.M., Oberg K., Chung D.C. et al. Gastroenteropancreatic neuroendocrine tumours // Lancet Oncol. 2008. V. 9. № 1. P. 61 - 72.
  34. Moran C.A., Suster S.Neuroendocrine carcinomas (carcinoid tumor) of the thymus. A clinicopathologic analysis of 80 cases // Am. J. Clin. Pathol. 2000. V. 114. № 1. P. 100 - 110.
  35. Moran C.A. Primary neuroendocrine carcinomas of the mediastinum: review of current criteria for histopathologic diagnosis and classification // Semin. Diagn. Pathol. 2005. V. 22. № 3. P. 223 - 229.
  36. Moran C.A., Kalhor N.Mediastinal neuroendocrine tumours // Diagnostic Histopathology. 2010. V. 16. Issue 5. P. 237 - 242.
  37. Moran C.A., Suster S., Coppola D. et al. Neuroendocrine carcinomas of the lung: a critical analysis // Am. J. Clin. Pathol. 2009. V. 131. P. 206 ? 221.
  38. Naalsund A., Rostad H., Strøm E.H. et al.Carcinoid lung tumors ? incidence, treatment and outcomes: a population-based study // Eur. J. Cardiothorac. Surg. 2011. V. 39. P. 565 - 569.
  39. Nagao T., Gaffey T.A., Olsen K.D. et al.Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome // Am. J. Surg. Pathol. 2004. V. 28. P. 762 - 770.
  40. Öberg K. Carcinoid tumors: molecular genetics, tumor biology, and update of diagnosis and treatment // Curr. Opin. Oncol. 2002. V. 14. P. 38 - 45.
  41. Öberg K., Jelic S.Neuroendocrine gastroenteropancreatic tumors: ESMO clinical recommendation for diagnosis, treatment and follow-up // Ann. Oncol. 2009. V. 20. Suppl. 4. P. 150 - 153.
  42. Öberg K., Hellman P., Ferolla P., Papotti M. Neuroendocrine bronchial and thymic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up // Ann. Oncol. 2012. V. 23.
    Suppl. 7. R. 120 - 123.
  43. Oberndorfer S. Kazinoide tumoren des Dunndarms // Z. Pathol. Frankf. 1907. V. 1. P. 426 - 432.
  44. OliveiraA.M.,TazelaarH.D.,MyersJ.L. et al. Thyroid transcription factor-1 distinguishes metastatic pulmonary from well differentiated NE tumors of other sites // Am. J. Surg. Pathol. 2001. V. 25.
    P. 815 - 819.
  45. Pan C.C., Jong Y.J., Chen Y.J. Comparative genomic hybridization analysis of thymic NE tumors // Modern Pathol. 2005. V. 18. P. 358 ? 364.
  46. PelosiG., RodriguezJ., VialeG.et al.Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients // Am. J. Surg. Pathol. 2005. V. 29. P. 179?187.
  47. Phan A.T., Oberg K., Choi J. et al.North American Neuroendocrine Tumor Society (NANETS): NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the thorax (includes lung and thymus) // Pancreas. 2010. V. 39. P. 784 - 798.
  48.  Rekhtman N. Neuroendocrine Tumors of the Lung: An Update // Archives of Pathology & Laboratory Medicine. 2010. V. 134. № 11. P. 1628 - 1638.
  49. Righi L., Volante M., Rapa I. et al.Neuroendocrine tumors of the lung: a review of relevant pathological and molecular data // Virchows Arch. 2007. V. 451. Suppl. 1. P. S51 - S59.
  50. Righi L., Volante M., Tavaglione V. et al.Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 "clinically aggressive" cases // Ann. Oncol. 2010. V. 21. P. 548-455.
  51. Rindi G., Bordi C.Endocrine tumours of the gastrointestinal tract: etiology, molecular pathogenesis and genetics // Best Pract. Res. Clin. Gastroenterol. 2005. V. 19. № 4. P. 519 - 534.
  52. Rindi G., Bordi C., Rappel S., Rosa S.L., Stolte M., Solcia E.Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior // World J. Surg. 1996. V. 20. № 2. P. 169 - 172.
  53. Rindi G., Klöppel G., Alhman H., Caplin M. et al.TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system // Virchows Arch. 2006. V. 449. P. 395 - 401.
  54. Rosai J., Higa E. Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid
    tumor. Clinicopathologic study of 8 cases // Cancer. 1972. V. 29. № 4.
    P. 1061 - 1074.
  55. Rusch V.W., Appleman H.D., Blacksto­ne E. et al. Lung // In: Edge S.B., Byrd D.R., Compton C.C., Fritz A.G., Greene F.L., Trotti A. (eds). AJCC Cancer Staging Manual, 7th edn. American Joint Commision on Cancer. Springer: Chicago. 2009. P. 253 - 270.
  56. Sagi A., Alexis D., Remotti F., Bhagat G.Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids // Am. J. Clin. Pathol. 2005. V. 123. № 3. P. 394 - 404.
  57. Schmitt A.M., Riniker F., Anlauf M.Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases //Am. J. Surg. Pathol. 2008. V. 32. № 3. P. 420 - 425.
  58. ShepherdF.A., Crowley., VanH.P.et al.The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer // J. Thorac. Oncol.2007. № 2. P. 1067?1077.
  59. Skov B.G.,Holm B.,Erreboe A. et al.ERCC1 and Ki67 in small cell lung carcinoma and other neuroendocrine tumors of the lung: distribution and impact on survival // J. Thorac. Oncol.2010. V. 5. № 4. P. 453 ? 459.
  60. Soga J. The term «carcinoid» is a misnomer: the evidence based on local invasion // J. Exp. Clin. Cancer Research. 2009. V. 28. P. 15.
  61. Solcia E., Klöppel G., Sobin L. Histological typing of endocrine tumours, 2nd ed. // WHO, Berlin: Springer. 2000.
  62. Srivastava A., Hornick J.L.Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors // Am. J. Surg. Pathol. 2009. V. 33. № 4. P. 626 - 632.
  63. Strosberg J.,Nasir A.,Coppola D. et al.Correlation between grade and prognosis in metastatic Gastroenteropancreatic neuroendocrine tumors //
    Hum. Pathol.2009. V. 40. № 9. P. 1262 - 1268.
  64. Sturm N., Rossi G., Lantuejoul S. et al.34BetaE12 expression along the whole spectrum of neuroendocrine proliferations of the lung, from neuroendocrine cell hyperplasia to small cell carcinoma // Histopathology.2003. V. 42. № 2. P. 156 - 166.
  65. Tang L.H.,Gonen M.,Hedvat C. et al.Objective quantification of the ki67 proliferative index in neuroendocrine tumors of the gastroenteropancreatic system: a comparison of digital image analysis with manual methods // Am. J. Surg. Pathol.2012. V. 36. № 12. P. 1761 - 1770.
  66. TravisW.D., ColbyT.V., CorrinB. in collaboration with L.H.Sobin and Pathologists from 14 Countries.et al.HistologicalTyping of Lung and Pleural Tumors, 3rd edn. // Springer. Berlin. 1999.
  67. TravisW.D., BrambillaE., Müller-HermelinkH.K., Harris C.C.Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart // World Health Organization Classification of Tumours. V. 10. IARC Press:Lyon, France.2004.
  68. Travis W.D., Giroux D.J., Chansky K. et al.The IASLC Lung Cancer Staging Project: proposals for the inclusion of broncho-pulmonary carcinoid tumors in the forthcoming (seventh) edition of the TNM Classification for Lung Cancer // J. Thorac. Oncol. 2008. V. 3. № 11. P. 1213 - 1223.
  69. Travis W.D.Advances in neuroendocrine lung tumors.Review // Ann. Oncol. 2010. V. 21. Suppl. 7. P. vii65 - vii71.
  70. Travis W.D. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas // Modern Pathology. 2012. V. 25. P. S18 - S30.
  71. WaltsA.E.,Ines D.,Marchevsky A.M.Limited role of Ki-67 proliferative index in predicting overall short-term survival in patients with typical and atypical pulmonary carcinoid tumors // Mod. Pathol.2012. V. 25. № 9. P. 1258 - 1264.
  72. Yao J.C., Hassan M., Phan A. et al.One hundred years after \"carcinoid\": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. Review // J. Clin. Oncol. 2008. V. 26.№ 18. P. 3063 - 3072.