350 руб
Журнал «Технологии живых систем» №8 за 2011 г.
Статья в номере:
Моделирование паркинсонизма у мышей при помощи МФТП: от ранней досимптомной до поздней сипмтомной стадии
Ключевые слова: мозг нигростриатная система дофамин паркинсонизм мыши 1-метил-4-фенил-1 2 3 6-тетрагидропиридин
Авторы:
М.В. Угрюмов, Е.А. Козина, В.Г. Хаиндрава, В.С. Кудрин, В.Г. Кучеряну, П.Д. Клодт, В.Б. Наркевич, Е.В. Бочаров, Г.Н. Крыжановский, К.С. Раевский
Аннотация:
В данном междисциплинарном исследовании с использованием ряда физиологических, биохимических и морфологических подходов впервые на мышах удалось смоделировать несколько важнейших стадий паркинсонизма. Полученные модели могут быть использованы в дальнейшем для: изучения молекулярных и клеточных механизмов ранних патологических процессов, связанных с деградацией не только дофаминергической нигростриатной системы, но и с деградацией других систем мозга, а также с нарушениями на периферии, что является ха-рактерными особенностями болезни Паркинсона у людей; оценки механизмов пластичности мозга, компенсирующих разрушение нигростриатной дофаминергической системы и других систем, связанных с регуляцией двигательных функций; поиска немоторных предвестников двигательных нарушений при болезни Паркинсона; поиска периферических биомаркеров досимптомной стадии болезни Паркинсона развития превентивной терапии с целью замедления дегенерации нигростриатных дофаминергических нейронов, а также с целью повышения эффективности эндогенных компенсаторных процессов
Страницы: 3-14
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