350 руб
Журнал «Технологии живых систем» №7 за 2011 г.
Статья в номере:
Инсулиноподобные факторы роста и их рецепторы при раке молочной железы
Ключевые слова: ИФР рецепторы ИФР ИФР-связывающие белки рак молочной железы таргетная противоопухолевая терапия
Авторы:
О.И. Костылева, Е.С. Герштейн, А.В. Масляев, У.Р. Мамедов
Аннотация:
Известно, что ИФР реализуют свои эффекты посредством взаимодействия с рецепторами и связывающими белками, образующими сложно регулируемую сеть взаимодействий как между собой, так и с другими регуляторами роста клеток, включенными в другие сигнальные каскады. Высокий уровень экспрессии ИФР-2 ассоциируется с плохим прогнозом при РМЖ, а повышенный уровень ИФР-1 в крови является независимым фактором риска РМЖ у женщин в пременопаузе. Перспективным в таргетной противоопухолевой терапии представляется подход, связанный с множественным воздействием на ИФР-сигнальный путь
Страницы: 3-11
Список источников
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