350 rub
Journal Technologies of Living Systems №7 for 2011 г.
Article in number:
IGF and their Receptors in Breast Cancer
Keywords: IGF IGF receptors IGF binding proteins breast cancer antitumor target therapy
Authors:
O.I. Kostyleva, E.S. Gershteyn, A.V. Maslyaev, U.R. Mamedov
Abstract:
IGF system includes IGF ligands, IGF receptors and IGF binding proteins, which interact widely with some other biological regulators of cell proliferation and growth. IGF signaling pathway activates mitogen activated proteinkinases cascade and P1-3K and Akt cascades, which inhibit apoptosis and stimulate cell proliferation. IGF are found mostly in stromal cells in breast tissue. High level of IGF-2 expression associates with poor prognosis in breast cancer, and increased circulating IGF-1 level is an independent rescue factor of breast cancer in premenopause. As a target for antitumor therapy could be perspective to try multiple action on IGF signaling pathway, including reduction and neutralization of IGF ligand, which downregulates IGF binding to receptors, and also developing of IGF independent antagonistic strategies
Pages: 3-11
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