350 руб
Журнал «Вопросы биологической, медицинской и фармацевтической химии» №3 за 2015 г.
Статья в номере:
Ингибиторы ферментов репарации ДНК как прототипы лекарственных препаратов
Ключевые слова: репарация ДНК поли(АДФ-рибозо)полимераза тирозил-ДНК-фосфодиэстераза ингибитор
Авторы:
А.Л. Захаренко - к.х.н., науч. сотрудник, Институт химической биологии и фундаментальной медицины, Сибирское отделение РАН (г. Новосибирск). E-mail: sashaz@niboch.nsc.ru Н.И. Речкунова - к.х.н., cт. науч. сотрудник, Институт химической биологии и фундаментальной медицины, Сибирское отделение РАН (г. Новосибирск). E-mail: nadyarec@niboch.nsc.ru О.И. Лаврик - д.х.н., зав. лабораторией, Институт химической биологии и фундаментальной медицины, Сибирское отделение РАН (г. Новосибирск); профессор, Новосибирский государственный университет. E-mail: lavrik@niboch.nsc.ru
Аннотация:
Стабильность генома высших эукариот во многом обеспечивается функционированием систем репарации ДНК. Активность этих систем может обусловливать устойчивость раковых клеток к химио- и радиотерапии, в связи с чем ферменты - участники и регуляторы систем репарации выступают как многообещающие терапевтические мишени. Рассмотрены современный уровень и перспективы исследований ингибирования трех ферментов репарации ДНК, а именно поли(АДФ-рибозо)полимераза 1 (PARP1), поли(АДФ-рибозо)полимераза 2 (PARP2) и тирозил-ДНК-фосфодиэстераза 1 (Tdp1), как фармакологических мишеней.
Страницы: 26-44
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