350 руб
Журнал «Вопросы биологической, медицинской и фармацевтической химии» №9 за 2014 г.
Статья в номере:
Редкоземельные элементы в живых системах
Авторы:
А.М. Анучин - к.б.н., вед. специалист по исследованиям, испытаниям и разработкам, ООО «Лаборатория спектральных исследований «Спектрум» (Москва). E-mail: a.anuchin@lspektrum.ru Г.Г. Ювс - директор, ООО «Лаборатория спектральных исследований «Спектрум». E-mail: g.youvs@lspektrum.ru
Аннотация:
Рассмотрено влияние редкоземельных элементов (РЗЭ) на человека и других млекопитающих, описано их влияние на здоровье в зависимости от способа попадания в организм. Обсуждено воздействие РЗЭ на ключевые системы органов. Особое внимание уделено токсическому влиянию больших концентраций РЗЭ на живые клетки и регуляцию клеточных процессов, а также положительным эффектам, проявляемым при использовании малых доз соединений РЗЭ.
Страницы: 39-46
Список источников

  1. Kawai K., Wang G., Okamoto S., Ochi K. The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp // FEMS microbiology letters. 2007. № 74. P. 311-315.
  2. Biasioli M, Fabietti G, Barberis R, Ajmone-Marsan F. An appraisal of soil diffuse contamination in an industrial district in northern Italy // Chemosphere. 2012. № 88. P. 1241-1249.
  3. Thomas PJ., Carpenter D., Boutin C., Allison J.E. Rare earth elements (REEs): Effects on germination and growth of selected crop and native plant species // Сhemosphere. 2013. № 23. P. 57-66.
  4. Hirano S., Suzuki K.T. Exposure, metabolism, and toxicity of rare earths and related compounds // Environmental Health Perspectives. 1996. V. 104. P. 85-95.
  5. Rabinowitz J.L., Gavarron F.F, Brand J. Tissue uptake and intracellular distribution of 140-lanthanum after oral intake by the rat // Journal of toxicology and environmental health. 1988. № 24. P. 229-235.
  6. Kostial K., Kargacin B., Landeka M. Gut retention of metals in rats // Biological trace element research. 1989. № 21. P. 213-218.
  7. Sullivan M.F., Miller B.M., Goebel J.C. Gastrointestinal absorption of metals // Environment research journal. 1984. № 35. P. 439-453.
  8. Ayadi A., Ali E.H., Tekaya L. Lysosomes of the liver and the duodenal enterocytes, a site of handling of two rare earths. Ultrastructural and microanalytical study // Biological trace element research. 2008. № 124. Р. 40-51.
  9. Manoubi-Tékaya L., Houcine N., Galle P. Role of lysosomes in the intracellular mineral elements: the case of lanthane // La Tunisie médicale. 2000. № 78. P. 195-200.
  10. Ohnishi K., Usuda K., Nakayama S., Sugiura Y., Kitamura Y., Kurita A. Distribution, elimination, and renal effects of single oral doses of europium in rats // Biological trace element research. 2011. № 143. P. 1054-1063.
  11. Berry J.P., Masse R., Escaig F., Galle P. Intracellular localization of cerium. A microanalytical study using an electron microprobe and ionic microanalysis // Human Toxicology. 1989. № 8. P. 511-520.
  12. Aime S., Caravan P. Biodistribution of gadolinium-based contrast agents, including gadolinium deposition // Journal of magnetic resonance imaging. 2009. № 30. P. 1259-1267.
  13. Kay J., Bazari H., Avery L.L., Koreishi A.F. Case records of the Massachusetts General Hospital. Case 6-2008. A 46-year-old woman with renal failure and stiffness of the joints and skin // The New England journal of medicine. 2008. №. 358. P. 827-838.
  14. Спасский С.С., Лашнев М.П. Актуальные проблемы гигиены труда. М. 1978.
  15. Андреева О.С., Киселев В.И., Малинина В.И. Редкоземельные элементы. Радиационно-гигиенические аспекты. М. 1975.
  16. Haley T.J., Komesu N., Efros M., Koste L., Upham H.C. Pharmacology and toxicology of lutetium chloride // Pharmaceutical Science. 1964. № 53. P. 1186-1188.
  17. Toya T., Takata A., Otaki N., Takaya M., Serita F., Yoshida K., Kohyama N. Pulmonary toxicity induced by intratracheal instillation of coarse and fine particles of cerium dioxide in male rats // Industrial health. 2010. № 48. P. 3-11.
  18. Censi P., Tamburo E., Speziale S., Zuddas P., Randazzo L.A., Punturo R. Yttrium and lanthanides in human lung fluids, probing the exposure to atmospheric fallout // Journal of hazardous materials. 2011. № 186. P. 1103-1110.
  19. Suzuki K.T., Kobayashi E., Ito Y., Ozawa H., Suzuki E. Localization and health effects of lanthanum chloride instilled intratracheally into rats // Toxicology, 1992. № 76. P. 141-152.
  20. Shen Z.C., Cheng Y., Zhang Q., Wei S.L., Li R.C., Wang K. Lanthanides enhance pulmonary absorption of insulin // Biological trace element research. 2000. № 75. P. 215-225.
  21. Ciceri P., Volpi E., Brenna I., Elli F., Borghi E., Brancaccio D. The combination of lanthanum chloride and the calcimimetic calindol delays the progression of vascular smooth muscle cells calcification // Biochemical and biophysical research communications. 2012. № 418. P. 770-773.
  22. Nikolov I.G., Joki N, Nguyen-Khoa T., Guerrera I.C., Maizel J., Benchitrit J. Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice // Nephrology, dialysis, transplantation. 2012. № 27. P. 505-513.
  23. Liu H., Zhang C., Huang K. Lanthanum chloride suppresses oxysterol-induced ECV-304 cell apoptosis via inhibition of intracellular Ca(2+) concentration elevation, oxidative stress, and activation of ERK and NF-κB signaling pathways // Journal of biological inorganic chemistry. 2011. № 16. P. 671-681.
  24. Zhao H., Cheng Z., Cheng J., Hu R., Che Y., Cui Y. The toxicological effects in brain of mice following exposure to cerium chloride // Biological trace element research. 2012. № 148. P. 134.
  25. Nagy I., Kadas I., Jobst K. Lanthanum Trichloride induced blood coagulation defect and liver injury // Haematologia. 1976. № 10. P. 353-359.
  26. Derrick T.S., Kashi R.S., Durrani M., Jhingan A., Middaugh C.R. Effect of metal cations on the conformation and inactivation of recombinant human factor VIII // European journal of pharmaceutical sciences. 2004. №. 93. P. 2549-2557.
  27. Vassallo D.V., Simões M.R., Furieri L.B., Fioresi M., Fiorim J., Almeida E.A. Toxic effects of mercury, lead and gadolinium on vascular reactivity // Brazilian journal of medical and biological research. 2011. № 44. P. 939-946.
  28. Valiathan S.M., Kartha C.C. Endomyocardial fibrosis--the possible connexion with myocardial levels of magnesium and cerium // International journal of cardiology. 1990. № 28. P.1-5.
  29. Kuruvilla L., Kartha C.C. Cerium depresses endocardial endothelial cell-mediated proliferation of cardiac fibroblasts // Biological trace element research. 2006. № 114. P. 85-92.
  30. Marciniak M., Baltrukiewicz Z., Chas J. The effect of toxic doses of lanthanum and cerium on the placental barrier and blood/organ barrier in mice after intravenous injection of these elements // Acta physiologica Polonica. 1988. № 39. P. 294-299.
  31. Salas M., Tuchweber B. Prevention by steroids of cerium hepatotoxicity // Archives of toxicology. 1976. № 36.P. 115-125.
  32. Strubelt O., Siegers C-P., Younes M. The influence of silybin on the hepatotoxic and hypoglycemic effects of praseodymium and other lanthanides // Arzneimittelforschung. 1980. № 30. P.1690-1694.
  33. Wu H., Zhang X., Li X., Wu Y., Pei F. Acute biochemical effects of La(NO3)3 on liver and kidney tissues by magic-angle spinning 1H nuclear magnetic resonance spectroscopy and pattern recognition // Analytical biochemistry. 2005. № 15. P. 242-248.
  34. Huang P., Li J., Zhang S., Chen C., Han Y., Liu N. Effects of lanthanum, cerium, and neodymium on the nuclei and mitochondria of hepatocytes: accumulation and oxidative damage // Environmental toxicology and pharmacology. 2011. № 31. P. 25-32.
  35. Li N., Cheng J., Cheng Z., Hu R., Cai J., Gao G. Molecular mechanism of inflammatory response in mouse liver caused by exposure to CeCl₃ // Environmental toxicology. 2013. V. 28. P. 349-358.
  36. Abdel-Zaher A.O., Abdel-Rahman M.M., Hafez M.M., Omran F.M. Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage // Toxicology. 2007. № 5. P. 124-134.
  37. Pałasz A., Czekaj P. Toxicological and cytophysiological aspects of lanthanides action // Acta biochimica Polonica. 2000. № 47. P. 1107-1114.
  38. Du S.S., Qiang M., Zeng Z.C., Ke A.W., Ji Y, Zhang Z.Y. Inactivation of kupffer cells by gadolinium chloride protects murine liver from radiation-induced apoptosis // International journal of radiation oncology, biology, physics. 2010. № 15. P. 1225-1234.
  39. Fan G.Q., Yuan Z.K., Zheng H.L., Liu Z.J. Study on the effects of exposure to rare earth elements and health-responses in children aged 7-10 years // Wei Sheng Yan Jiu. 2004. № 33. P. 23-28.
  40. Summers M.J., Crowe S.F., Ng K.T. Administration of lanthanum chloride following a reminder induces a transient loss of memory retrieval in day-old chicks // Neuroscience and biobehavioral reviews. 2003. № 27. P. 219-231.
  41. Yang J., Liu Q., Zhang L., Wu S., Qi M., Lu S. Lanthanum chloride impairs memory, decreases pCaMK IV, pMAPK and pCREB expression of hippocampus in rats // Toxicology letters. 2009. № 28. P. 208-214.
  42. Hao S., Yu F., Yan A., Zhang Y., Han J., Jiang X. In utero and lactational lanthanum exposure induces olfactory dysfunction associated with downregulation of βIII-tubulin and olfactory marker protein in young rats // Biological trace element research. 2012. № 148. P. 383-391.
  43. Mlinar B., Enyeart J.J. Block of current through T-type calcium channels by trivalent metal cations and nickel in neural rat and human cells // Physiology journal.1993. № 469. P. 639-652.
  44. Das T., Sharma A., Talukder G. Effects of lanthanum in cellular systems // Biological trace element research. 1988. № 18. P. 201-228.
  45. Wu J., Yang J., Liu Q., Wu S. Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca²⁺ and Bcl-2 family // Biological trace element research. 2013. № 152. P. 125-134.
  46. Hardas S.S., Sultana R., Warrier G., Dan M., Florence R.L., Wu P.Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure // Neurotoxicology. 2012. № 33. P. 1147-1155.
  47. Xia Q., Feng X., Huang H., Du L., Yang X., Wang K. Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons // Journal of neurochemistry. 2011. № 117. P. 38-47.
  48. Vidaud C., Bourgeois D., Meyer D. Bone as Target Organ for Metals: The Case of f-Elements // Chemical research in toxicology. 2012. № 25. P. 1161−1175.
  49. Herath H., Di Silvio L., Evans J. In vitro evaluation of samarium (III) oxide as a bone substituting material // Journal of biomedical materials research. 2009. № 94. P. 130−136.
  50. Webster T.J., Massa-Schlueter E.A., Smith J.L., Slamovich E.B. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations // Biomaterials. 2004. № 25. P. 2111−2121.
  51. Yu S., Hu J., Yang X., Wang K., Qian Z. M. La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells // Biochemistry. 2006. № 45. P.11217−11225.
  52. Zaichick S., Zaichick V., Karandashev V., Nosenko S. Accumulation of rare earth elements in human bone within the lifespan // Metallomics. 2011. № 3. P. 186-194.
  53. Behets G.J., Verberckmoes S.C., Oste L., Bervoets A.R., Salomé M., Cox A.G. Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate // Kidney international. 2005. № 67. P. 1830-1836.
  54. Mawani Y., Cawthray J.F., Chang S., Sachs-Barrable K., Weekes D.M., Wasan K.M. In vitro studies of lanthanide complexes for the treatment of osteoporosis // Dalton transactions. 2013. № 7. P. 5999-6011.
  55. Maulik G., Ghosh N., Sengupta T., Chattopadhyay D., Chakraborty A.K., Chatterjee G.C. Curative effect of methionine on certain enzymes of chick kidney cortex under lanthanum toxicity situation // Indian journal of experimental biology. 1992. № 30. P. 1166-1169.
  56. Kitamura Y., Usuda K., Shimizu H., Fujimoto K., Kono R., Fujita A. Urinary monitoring of exposure to yttrium, scandium, and europium in male Wistar rats // Biological trace element research. 2012. № 150. P. 322-327.
  57. Weiss G.B., Goodman F.R. Distribution of a lanthanide (147Pm) in vascular smooth muscle // The journal of pharmacology and experimental therapeutics. 1976. № 198. P. 366-374.
  58. Bennett C.L., Starko K.M., Thomsen H.S., Cowper S., Sartor O., Macdougall I.C. Linking drugs to obscure illnesses: lessons from pure red cell aplasia, nephrogenic systemic fibrosis, and Reye's syndrome. a report from the Southern Network on Adverse Reactions (SONAR) // Journal of general internal medicine. 2012. № 27. P. 1697-1703.
  59. Gramowski A., Jügelt K., Schröder O.H., Weiss D.G., Mitzner S. Acute functional neurotoxicity of lanthanum(III) in primary cortical networks // Toxicological sciences. 2011. № 120. P. 173-183.
  60. Shrivastava S., Mathur R. Effectiveness of ethylene glycol bis (2-aminoethyl ether) tetraacetic acid (EGTA) against cerium toxicity // Indian journal of experimental biology. 2004. № 42. P. 876-883.