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Журнал «Вопросы биологической, медицинской и фармацевтической химии» №3 за 2014 г.
Статья в номере:
Эпигенетические механизмы регуляции экспрессии генов в химическом канцерогенезе
Ключевые слова: химический канцерогенез эпигенетика метилирование ДНК модификации гистонов микроРНК альтернативная конформация ДНК регуляция экспрессии генов
Авторы:
Н.А. Шалгинских - лаборант-исследователь, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: nshalgin@mail.ru Н.Ю. Карпеченко - мл. науч. сотрудник, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: nojadg@mail.ru А.М. Оглоблина - мл. науч. сотрудник, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: globbi@mail.ru Е.А. Лесовая - к.б.н., науч. сотрудник, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: lesovenok@yandex.ru К.И. Кирсанов - к.б.н., ст. науч. сотрудник, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: mrkir@rambler.ru Д.С. Набережнов - аспирант, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: n41d23s05@gmail.com Г.А. Белицкий - д.м.н., профессор, вед. науч. сотрудник, отдел химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: belitsga@mail.ru М.Г. Якубовская - д.м.н., руководитель отдела химического канцерогенеза, ФГБУ «РОНЦ им. Н.Н.Блохина» РАМН (Москва). E-mail: mgyakubovskaya@mail.ru
Аннотация:
Рассмотрены исследования в области химического канцерогенеза, направленные на изучение молекулярных механизмов действия негенотоксических канцерогенов, промоторов канцерогенеза и антиканцерогенов. Показано, что данные по участию ксенобиотиков в процессах регуляции экспрессии генов делают актуальными вопросы тестирования соединений на эпигенетическую активность, первичной профилактики онкологических заболеваний, определения риска их развития после экспозиции к эпигенетическим канцерогенам.
Страницы: 46-64
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