350 rub
Journal №3 for 2014 г.
Article in number:
Epigenetic regulation of gene expression in chemical carcinogenesis
Keywords: chemical cercinogenesis epigenetics DNA methylation histone modification microRNA alternative DNA expression regulation
Authors:
N.A. Shalginskikh - Laboratory Assistant, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: nshalgin@mail.ru
N.Y. Karpechenko - Assistant Researcher, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: nojadg@mail.ru
A.M. Ogloblina - Assistant Researcher, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: globbi@mail.ru
E.A. Lesovaya - Ph.D. (Biol.), Researcher, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: lesovenok@yandex.ru
K.I. Kirsanov - Ph.D. (Biol.), Senior Researcher, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: mrkir@rambler.ru
D.S. Naberezhnov - Post-graduate Student, Department of Chemical Carcinogenesis, Blokhin Cancer Research Center RAMS. E-mail: n41d23s05@gmail.com
G.A. Belitsky - M.D., Ph.D., D.Sc., Professor, Leading Researcher, Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: belitsga@mail.ru M.G. Yakubovskaya - M.D., Ph.D., D.Sc. (Med.), Head of the Department of Chemical Carcinogenesis Blokhin Cancer Research Center RAMS. E-mail: mgyakubovskaya@mail.ru
Abstract:
Currently, in the field of chemical carcinogenesis primarily research is aimed to study molecular effects of non-genotoxic carcinogens, promoters and anticarcinogens due to growing recognition of the importance of epigenetic mechanisms of gene expression regulation. The main basis of epigenetic regulation of transcription is two closely interrelated systems: DNA methylation and chemical modification of histones by special enzymes. Besides that microRNAs participate in the regulation of genome functions via inhibition of transcription and mRNA processing. Recently the role of alternative DNA conformations in transcription inhibition was also confirmed. Recent data reveal the participation of xenobiotics in epigenetic regulation of gene expression. This makes relevant incorporating of epigenetics and epigenomics into carcinogen identification and safety assessment. Moreover, anticancer therapy based on epigenetic regulatory process represents a new promising approach.
Pages: 46-64
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