350 руб
Журнал «Вопросы биологической, медицинской и фармацевтической химии» №6 за 2013 г.
Статья в номере:
Современные представления о метаболизме и физиологических функциях витамина D в организме (обзор)
Ключевые слова:
витамин D
кальцитриол
костный метаболизм
иммуномодулирующее действие
антиканцерогенный эффект
нейропротекторный эффект
Авторы:
И.Н. Захарова - д.м.н., заслуженный врач России, профессор, зав. кафедрой педиатрии, Российская медицинская академия последипломного образования. E-mail: zakharova-rmapo@yandex.ru
Н.А. Коровина - д.м.н., заслуженный врач России, профессор, кафедра педиатрии, Российская медицинская академия последипломного образования. E-mail: kafedra25@yandex.ru
Ю.А. Дмитриева - к.м.н., ассистент, кафедра педиатрии, Российская медицинская академия последипломного образования. E-mail: jadmitrieva@mail.ru
Аннотация:
Доказано, что почечный метаболит витамина D обладает гормональной активностью, регулируя многие обменные процессы в организме человека. Представлены современные данные о метаболизме холекальциферола в организме человека, описаны молекулярные механизмы действия кальцитриола, продемонстрирована роль витамина D в профилактике различных заболеваний у детей и взрослых.
Страницы: 35-42
Список источников
- Holick M.F. Phylogentic and evolutionary aspects of vitamin D from phytoplankton to human / In: Vertebrate endocrinology: fundamentals and biomedical implications, P. Pang ed. Florida: Academic Press. 1989. P. 7-43.
- Novikov P.V. Raxit i nasledstvenny'e raxitopodobny'e zabolevaniya u detej. M.:Triada-X. 2006. 336 c.
- DeLuca H.F. Overview of general physiologic features and functions of vitamin D // Am. J. Clin. Nutr.2004. V. 80(Suppl.). P. 1689-1696.
- Prentice A., Goldberg G.R., Schoenmakers I. Vitamin D across the lifestyle: physiology and biomarkers // Am. J. Clin. Nutr. 2008. V. 88. P. 500-506.
- Smith E.L., Holick M.F. The skin: the site of vitamin D3 synthesis and a target tissue for its metabolite, 1,25-dihydroxyvitamin D3 // Steroids. 1987. V. 49. P. 103-107.
- MacLaughlin J.A., Anderson R.R., Holick M.F. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin // Science. 1982. V. 216. P. 1001-1003.
- Holick M.F. Resurrection of vitamin D deficiency and rickets // Clin. Invest. 2006. V. 116 (8). P. 2062-2072.
- Holick M.F. The vitamin D epidemic and its health consequences // J. Nutr.2005. V. 135(11). P. 2739-2748.
- Bouillon R.,Saunders W.B. Vitamin D: from photosynthesis, metabolism, and action to clinical applications / In Endocrinology.L.J. DeGroot and J.L. Jameson, ed. Philadelphia, Pennsylvania, 2001. USA. P. 1009-1028.
- Holick M.F. High prevalence of vitamin D inadequacy and implications for health // Mayo Clin. Proc. 2006. V. 81. P. 353-373.
- Markestad T., Halvorsen S., Halvorsen K.S., Aksnes L., Aarskog D. Plasma concentrations of vitamin D metabolites before and during treatment of vitamin D deficiency rickets in children // Acta Paediatr. Scand.1984. V. 73. P. 225-231.
- Christakos S., Dhawan P., Liu Y., Peng X., Porta A. New insights into the mechanisms of vitamin D action // J. Cell. Biochem. 2003. V. 88. P. 695-705.
- Henry H.L. The 25-hydroxyvitamin D 1 α-hydroxylase / In: Vitamin D. D. Feldman, J.W. Pike, F.H. Glorieux, eds. San Diego. CA: Elsevier Academic Press. 2005. P. 69-83.
- Norman A.W. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health // American Journal of Clinical Nutrition. V. 88. № 2. Р. 491-499.
- Sivri S.K. Vitamin D metabolism. In Calcium and vitamin D metabolism ed. by A.Hasanoglu published by Danone Institute Turkey Association. 2010. P. 5-13.
- Johnson J.A., Kumar R. Renal and intestinal calcium transport: roles of vitamin D and vitamin D-dependent calcium binding proteins // Semin Nephrol. 1994 Mar. V. 14(2). P. 119-128.
- Wasserman R.H., Fullmer C.S. On the molecular mechanism of intestinal calcium transport // Adv Exp Med Biol. 1989. V. 249. P. 45-65.
- DeLuca H.F. Vitamin D-dependent calcium transport // Soc. Gen. Physiol. Ser. 1985. V. 39. P. 159-176.
- Hofbauer L.C., Heufelder A.E.Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology // J. Mol. Med. 2001. Jun. V. 79(5-6). P. 243-53.
- Wada T., Nakashima T., Hiroshi N., Penninger J.M.RANKL-RANK signaling in osteoclastogenesis and bone disease // Trends Mol Med. 2006 Jan. V. 12(1). P. 17-25. Epub 2005 Dec 13.
- Kazyulin A.N. Vitamin D. M.: OOO NTC AMT. 2007. 74s.
- Hayes C.E., Nashold F.E., Spach K.M., Pedersen L.B. The immunological functions of the vitamin D endocrine system // Cell. Mol. Biol. (Noisy-le-grand). 2003 Mar. V. 49(2). P. 277-300.
- DeLuca H.F., Cantorna M.T. Vitamin D: its role and uses in immunology // FASEB J. 2001 Dec. V. 15(14). P. 2579-2585
- Lemire J.M. 1,25-dihydroxyvitamin D3 - a hormone with immunomodulatory properties // Z. Rheumatol. 2000. V. 59 Suppl 1. P. 24-27.
- Cantorna M.T., Mahon B.D. D-hormone and the immune system // J. Rheumatol Suppl. 2005. Sep. V. 76. P. 11-20.
- Thomasset M. Vitamin D and the immune system // Pathol Biol (Paris). 1994 Feb. V. 42(2). P. 163-172.
- Liu P.T., Stenger S., Li H. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response // Science 2006. V. 311. P. 1770-1773.
- Chan T.Y. Vitamin D deficiency and susceptibility to tuberculosis // Calcif Tissue Int 2000 Jun. V. 66(6). P. 476-478.
- Wilkinson R.J., Liewelyn M., Toosi Z., Patel P., Pasvol G. et al. Influence of vitamin D deficienct and vitamin D receptorpolymorfisms on tuberculosis in Gujarati Asians in west London; A case control study // Lancet. 2000. V. 365. P. 618-621.
- Tumer L. The extra-osseous effects of vitamin D. In Calcium and vitamin D metabolism / ed. by A. Hasanoglu, published by Danone Institute Turkey Association. 2010. P. 13-23.
- Chen C.Y, Schwartz G.G., Burnstein K.L. et al.The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer // Clin. Cancer. Res. 2000 Mar. V. 6(3). P. 901-908.
- Sung V., Feldman D. 1,25 dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration // Mol. Cell. Endocrinol. 2000. Jun. V. 164 (1-2). P. 133-143.
- Konety B.R., Lavelle J.P., Pirtskalaishvili G. et al.Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo // J. Urol. 2001. Jan. V. 165(1). P. 253-258.
- Garland C.F., Garland F.C., Gorham E.D. et al.Geographic variations in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation // Prev. Med. 1990. V. 19. P. 614-622.
- Garland C.F., Garland F.C., Gorham E.D. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention // Ann NY Acad. Sci. 1999. P. 889. P. 107-119.
- Garland C.F., Garland F.C. Do vitamin D and sunlight reduce the risk of colon cancer - // Int. J. Epidemiol. 1980. V. 9. P. 227-231.
- Fujioka T., Suzuki Y., Okamoto T. et al.Prevention of renal cell carcinoma by active vitamin D3 // World J. Surg. 2000 Oct. V. 24(10). P. 1205-1210.
- Manolagas S.C., Yu X.P., Girasole G. et al.Vitamin D and hematolimphopoietic tissue: a 1994 update // Semin Nephrol. 1994. Mar. V. 14(2). P. 129-143.
- Tanaka H., Abe E., Miyaura C. et al. 1 alpha,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60). Biochem J. 1982. V. 204. P. 713-719.
- Suda T., Abe E., Miyaura C. et al.Induction of differentiation of human myeloid leukemia cells by la,25-dihydroxyvitamin D3 / In: A.W. Norman, K. Schaefer, D.V. Herrath, H.G. Grigdeit eds. Vitamin D, Chemical, Biochemical, and Clinical Endocrinology of Calcium Metabolism: Proceedings of the Fifth Workshop on Vitamin D, Williamsburg. VA. USA, February 1982. Berlin, Germany: Walter de Gruyter. 1982. P. 59-64.
- Li Y.C., Kong J., Wei M., Chen Z.F., Liu S.Q., Cao L.P.1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system // J. Clin. Invest. 2002. V. 110. P. 229-38.
- Pfeifer M., Begerow B., Minne H.W., Nachtigall D., Hansen C. Effects of a short term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women // J. Clin. Endocrinol Metab. 2001. P. 86. P. 1633-1637.
- Wang T.J., Pencina M.J., Booth S.L., Jacques P.F. et al.Vitamin D deficiency and Rsik of Cardiovascular disease. 2008. V. 117. P. 513-511.
- Pittas A.G., Lau J., Hu F.B., Hughes B.D.The role of vitamin D and calcium in Type 2 diabetes. A systemic review and meta- analysis // JCEM. 2007. P. 2017-2029.
- Majdannik V.G. Raxit u detej: sovremenny'e aspekty'. Nezhin. aspekt-Poligraf. 2006.
- McGrath J., Eyles D., Mowry B., Yolken R., Buka S. Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophr Res. 2003. V. 63. P. 73-78.
- Harms L.R., Eyles D.W., McGrath J.J. et al. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice // Behav. Brain. Res. 2008. V. 187. P. 343-350.
- Przybelski R.J., Binkley N.C. Is vitamin D important for preserving cognition A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function // Arch. Biochem. Biophys. 2007. V. 460. P. 202-205.
- Brown A.J., Dusso A., Slatopolsky E. Vitamin D // Am. J. Physiol. Renal. Phisiol. 1999. V. 277. P. F157-175.