350 rub
Journal №6 for 2013 г.
Article in number:
Modern view of metabolism and physiological functions of vitamin D (overview)
Keywords:
vitamin D
calcitriol
bone metabolism
immunomodulating activity
anticarcinogenic effect
neuroprotective effect
Authors:
I.N. Zakharova, N.A. Korovina, Yu. A. Dmitrieva
Abstract:
Recent studies changed current view on vitamin D. It is well known now that kidney metabolite of vitamin D can act as a hormone. Receptors to calcitriol were found in the majority of organs and tissues where it regulates cell proliferation and differentiation, takes part in immunoregulation and metabolism. Modern data show strong link between hypovitaminosis D and high risk of cardiovascular, infectious and autoimmune diseases, oncologic processes and obesity. At present there is no doubts that there is a need for adequate vitamin D intake through the whole life. Sufficient level of vitamin D in organism has a crucial role not just in rickets prevention in infancy but in reducing long-term consequences of it-s deficiency.
Pages: 35-42
References
- Holick M.F. Phylogentic and evolutionary aspects of vitamin D from phytoplankton to human / In: Vertebrate endocrinology: fundamentals and biomedical implications, P. Pang ed. Florida: Academic Press. 1989. P. 7-43.
- Novikov P.V. Raxit i nasledstvenny'e raxitopodobny'e zabolevaniya u detej. M.:Triada-X. 2006. 336 c.
- DeLuca H.F. Overview of general physiologic features and functions of vitamin D // Am. J. Clin. Nutr.2004. V. 80(Suppl.). P. 1689-1696.
- Prentice A., Goldberg G.R., Schoenmakers I. Vitamin D across the lifestyle: physiology and biomarkers // Am. J. Clin. Nutr. 2008. V. 88. P. 500-506.
- Smith E.L., Holick M.F. The skin: the site of vitamin D3 synthesis and a target tissue for its metabolite, 1,25-dihydroxyvitamin D3 // Steroids. 1987. V. 49. P. 103-107.
- MacLaughlin J.A., Anderson R.R., Holick M.F. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin // Science. 1982. V. 216. P. 1001-1003.
- Holick M.F. Resurrection of vitamin D deficiency and rickets // Clin. Invest. 2006. V. 116 (8). P. 2062-2072.
- Holick M.F. The vitamin D epidemic and its health consequences // J. Nutr. 2005. V. 135(11). P. 2739-2748.
- Bouillon R.,Saunders W.B. Vitamin D: from photosynthesis, metabolism, and action to clinical applications / In Endocrinology.L.J. DeGroot and J.L. Jameson, ed. Philadelphia, Pennsylvania, 2001. USA. P. 1009-1028.
- Holick M.F. High prevalence of vitamin D inadequacy and implications for health // Mayo Clin. Proc. 2006. V. 81. P. 353-373.
- Markestad T., Halvorsen S., Halvorsen K.S., Aksnes L., Aarskog D. Plasma concentrations of vitamin D metabolites before and during treatment of vitamin D deficiency rickets in children // Acta Paediatr. Scand.1984. V. 73. P. 225-231.
- Christakos S., Dhawan P., Liu Y., Peng X., Porta A. New insights into the mechanisms of vitamin D action // J. Cell. Biochem. 2003. V. 88. P. 695-705.
- Henry H.L. The 25-hydroxyvitamin D 1 α-hydroxylase / In: Vitamin D. D. Feldman, J.W. Pike, F.H. Glorieux, eds. San Diego. CA: Elsevier Academic Press. 2005. P. 69-83.
- Norman A.W. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health // American Journal of Clinical Nutrition. V. 88. № 2. Р. 491-499.
- Sivri S.K. Vitamin D metabolism. In Calcium and vitamin D metabolism ed. by A.Hasanoglu published by Danone Institute Turkey Association. 2010. P. 5-13.
- Johnson J.A., Kumar R. Renal and intestinal calcium transport: roles of vitamin D and vitamin D-dependent calcium binding proteins // Semin Nephrol. 1994 Mar. V. 14(2). P. 119-128.
- Wasserman R.H., Fullmer C.S. On the molecular mechanism of intestinal calcium transport // Adv Exp Med Biol. 1989. V. 249. P. 45-65.
- DeLuca H.F. Vitamin D-dependent calcium transport // Soc. Gen. Physiol. Ser. 1985. V. 39. P. 159-176.
- Hofbauer L.C., Heufelder A.E.Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology // J. Mol. Med. 2001. Jun. V. 79(5-6). P. 243-53.
- Wada T., Nakashima T., Hiroshi N., Penninger J.M. RANKL-RANK signaling in osteoclastogenesis and bone disease // Trends Mol Med. 2006 Jan. V. 12(1). P. 17-25. Epub 2005 Dec 13.
- Kazyulin A.N. Vitamin D. M.: OOO NTC AMT. 2007. 74s.
- Hayes C.E., Nashold F.E., Spach K.M., Pedersen L.B. The immunological functions of the vitamin D endocrine system // Cell. Mol. Biol. (Noisy-le-grand). 2003 Mar. V. 49(2). P. 277-300.
- DeLuca H.F., Cantorna M.T. Vitamin D: its role and uses in immunology // FASEB J. 2001 Dec. V. 15(14). P. 2579-2585
- Lemire J.M. 1,25-dihydroxyvitamin D3 - a hormone with immunomodulatory properties // Z. Rheumatol. 2000. V. 59 Suppl 1. P. 24-27.
- Cantorna M.T., Mahon B.D. D-hormone and the immune system // J. Rheumatol Suppl. 2005. Sep. V. 76. P. 11-20.
- Thomasset M. Vitamin D and the immune system // Pathol Biol (Paris). 1994 Feb. V. 42(2). P. 163-172.
- Liu P.T., Stenger S., Li H. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response // Science 2006. V. 311. P. 1770-1773.
- Chan T.Y. Vitamin D deficiency and susceptibility to tuberculosis // Calcif Tissue Int 2000 Jun. V. 66(6). P. 476-478.
- Wilkinson R.J., Liewelyn M., Toosi Z., Patel P., Pasvol G. et al. Influence of vitamin D deficienct and vitamin D receptorpolymorfisms on tuberculosis in Gujarati Asians in west London; A case control study // Lancet. 2000. V. 365. P. 618-621.
- Tumer L. The extra-osseous effects of vitamin D. In Calcium and vitamin D metabolism / ed. by A. Hasanoglu, published by Danone Institute Turkey Association. 2010. P. 13-23.
- Chen C.Y, Schwartz G.G., Burnstein K.L. et al.The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer // Clin. Cancer. Res. 2000 Mar. V. 6(3). P. 901-908.
- Sung V., Feldman D. 1,25 dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration // Mol. Cell. Endocrinol. 2000. Jun. V. 164 (1-2). P. 133-143.
- Konety B.R., Lavelle J.P., Pirtskalaishvili G. et al.Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo // J. Urol. 2001. Jan. V. 165(1). P. 253-258.
- Garland C.F., Garland F.C., Gorham E.D. et al. Geographic variations in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation // Prev. Med. 1990. V. 19. P. 614-622.
- Garland C.F., Garland F.C., Gorham E.D. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention // Ann NY Acad. Sci. 1999. P. 889. P. 107-119.
- Garland C.F., Garland F.C. Do vitamin D and sunlight reduce the risk of colon cancer - // Int. J. Epidemiol. 1980. V. 9. P. 227-231.
- Fujioka T., Suzuki Y., Okamoto T. et al.Prevention of renal cell carcinoma by active vitamin D3 // World J. Surg. 2000 Oct. V. 24(10). P. 1205-1210.
- Manolagas S.C., Yu X.P., Girasole G. et al.Vitamin D and hematolimphopoietic tissue: a 1994 update // Semin Nephrol. 1994. Mar. V. 14(2). P. 129-143.
- Tanaka H., Abe E., Miyaura C. et al. 1 alpha,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60). Biochem J. 1982. V. 204. P. 713-719.
- Suda T., Abe E., Miyaura C. et al.Induction of differentiation of human myeloid leukemia cells by la,25-dihydroxyvitamin D3 / In: A.W. Norman, K. Schaefer, D.V. Herrath, H.G. Grigdeit eds. Vitamin D, Chemical, Biochemical, and Clinical Endocrinology of Calcium Metabolism: Proceedings of the Fifth Workshop on Vitamin D, Williamsburg. VA. USA, February 1982. Berlin, Germany: Walter de Gruyter. 1982. P. 59-64.
- Li Y.C., Kong J., Wei M., Chen Z.F., Liu S.Q., Cao L.P. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system // J. Clin. Invest. 2002. V. 110. P. 229-38.
- Pfeifer M., Begerow B., Minne H.W., Nachtigall D., Hansen C. Effects of a short term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women // J. Clin. Endocrinol Metab. 2001. P. 86. P. 1633-1637.
- Wang T.J., Pencina M.J., Booth S.L., Jacques P.F. et al. Vitamin D deficiency and Rsik of Cardiovascular disease. 2008. V. 117. P. 513-511.
- Pittas A.G., Lau J., Hu F.B., Hughes B.D.The role of vitamin D and calcium in Type 2 diabetes. A systemic review and meta- analysis // JCEM. 2007. P. 2017-2029.
- Majdannik V.G. Raxit u detej: sovremenny'e aspekty'. Nezhin. aspekt-Poligraf. 2006.
- McGrath J., Eyles D., Mowry B., Yolken R., Buka S. Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophr Res. 2003. V. 63. P. 73-78.
- Harms L.R., Eyles D.W., McGrath J.J. et al. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice // Behav. Brain. Res. 2008. V. 187. P. 343-350.
- Przybelski R.J., Binkley N.C. Is vitamin D important for preserving cognition A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function // Arch. Biochem. Biophys. 2007. V. 460. P. 202-205.
- Brown A.J., Dusso A., Slatopolsky E. Vitamin D // Am. J. Physiol. Renal. Phisiol. 1999. V. 277. P. F157-175.