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Журнал «Вопросы биологической, медицинской и фармацевтической химии» №12 за 2013 г.
Статья в номере:
Молекулярные механизмы гормональной резистентности рака молочной железы: роль сигнальных путей NF-kappaB и Snail1
Ключевые слова: рак молочной железы эпителиально-мезенхимальный переход Snail1 ERα эстрогены NF-κ B
Авторы:
А.М. Щербаков - к.б.н., ст. науч. сотрудник, Российский онкологический научный центр им. Н.Н. Блохина РАМН (Москва) О.Е. Андреева - мл. науч. сотрудник, Российский онкологический научный центр им. Н.Н. Блохина РАМН (Москва) А.А. Шарапов - лаборант, Российский онкологический научный центр им. Н.Н. Блохина РАМН (Москва) Р.К. Таноян - лаборант, Российский онкологический научный центр им. Н.Н. Блохина РАМН (Москва)
Аннотация:
Рассмотрены основные механизмы гормональной резистентности рака молочной железы; проанализировано формирование на молекулярном уровне устойчивости опухоли к действию гормональных цитостатических препаратов. Освещены два белка - NF-κB и Snail1, и их роль при развитии гормональной резистентности.
Страницы: 42-52
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