350 rub
Journal №12 for 2013 г.
Article in number:
The molecular mechanisms of hormonal resistance of breast cancer: the role of NF-kappaB and Snail1 signaling pathways
Authors:
A.M. Scherbakov - Ph.D., Senior Researcher, Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian Federation
O.E. Andreeva - Junior Researcher, Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian Federation
A.A. Sharapov - Laboratory Assistant, Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian Federation
R.K. Tanoyan - Laboratory Assistant, Federal State Budgetary Institution «The N.N. Blokhin Russian Cancer Research Center» of the Russian Academy of Medical Sciences, Moscow, Russian Federation
Abstract:
The basic mechanisms of hormonal resistance were considered in the review; the molecular pathways responsible for the development of the tolerance of tumor to hormonal cytostatic drugs were analyzed. Two proteins, NF-κB и Snail1 and their roles in the development of hormonal resistance were discussed in detail. The important factors of the hormonal resistance are: 1) the increase of Snail1 expression, 2) the changes in NF-κB activity, 3) the coordinated negative action of NF-κB and Snail1 pathways on estrogen receptors machinery in breast cancer. Thus Snail1 and NF-κB may serve as perspective targets in the treatment of breast cancer, particularly the hormonal resistant tumors.
Pages: 42-52
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