S.V. Smirnov1

1 Samara State Medical University (Samara, Russia)
1 s.v.smirnov@samsmu.ru

The scale of oncology as a problem for humanity as a whole, including the steady increase in the number of cases, remains very impressive to this day. Chemotherapy is one of the leading ways to solve this problem. The frequency of occurrence, geography and occurrence of different types of cancerous tumors are formed under the influence of various etiological factors. Of these, gender, age, ethnic (racial), genetic predisposition, as well as the influence of a wide range of environmental carcinogens are the most significant. Perhaps the last of them is the most relevant in the modern world. There is enough scientific evidence in the world literature for a direct correlation between carcinogens, in particular in the composition of tobacco smoke, which is widespread in tobacco smoking and is especially popular among young people, including adolescents, not counting all kinds of azo dyes, aflatoxins, benzene derivatives that induce malignancy. One way or another, regardless of the cause, in the pathochemistry of cancer, a violation of the biochemical control mechanisms that determine cell proliferation and differentiation always comes to the fore. Cells exposed to carcinogen and undergoing the process of neoplasia actively express on their surface antigenic molecules in the membrane apparatus of cells, which are inherently "embryonic type", that is, they have obvious signs of their immaturity and undifferentiation. Neoplasia processes eventually develop into a more powerful invasion and metastasis, resulting in exophytic growth and ultimately death of the patient. However, the successes of modern chemotherapy today make it possible to "resist" the pathogenesis of such disseminated nosological units as testicular cancer, diffuse lipoma, Hodgkin's disease, choriocarcinoma, acute lymphoblastic leukemia, Burkitt's lymphoma, Wilms tumor and rhabdomyosarcoma in children, which makes it urgent to constantly search for new drugs that would expand this list of controlled targeted drugs. chemotherapy of severe diseases. In this scientific manuscript, we bring to the reader's attention an experimental model that sheds light on one of the biochemical processes occurring in cells under the influence of a divalent platinum preparation. The aim of the work is to investigate one of the possible additional pharmacodynamic properties of platinum preparations – the mechanism of activation of cell apoptosis in experimental models of inhibition of phosphorylation of the amino acid L-serine as one of the possible mechanisms in a living cell, in our opinion, regulating phosphorylation of the proapoptotic protein BAD (either BNIP3 and Nix (Bnip3-like, Bnip3L), homologous proteins of the BCL-2 family) at the 136-Ser residue, which prevents the dissociation of the BCL-2/BCL-X complex and, as a result, leads to the loss of its main proapoptotic function by the protein.

Smirnov S.V. Modeling of biochemical processes in the pharmacodynamics of Pt (ΙΙ/ΙV) preparations. Nanotechnology: development and applications – XXI century. 2026. V. 18. № 1. P. 40–46. DOI: https://doi.org/10.18127/j22250980-202601-04 (in Russian)

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