350 rub
Journal Biomedical Radioelectronics №3 for 2015 г.
Article in number:
High-frequency ultrasound Doppler imaging in assessment of tissue microcirculation and vasoregulation endothelial function in patients with cardiovascular diseases
Keywords:
high-frequency Doppler ultrasound
microcirculation
Endothelial dysfunction
cardiovascular disease
Authors:
O.L. Bockeria - Dr.Sc. (Med.), Professor, Leading Research Scientist, Bakoulev Center for CVS (Moscow)
N.T. Salia - Dr.Sc. (Med.), Senior Scientist Research, Bakoulev Center for CVS 135 Roublevskoe Shosse (Moscow). E-mail: natsalia@mail.ru
M.A. Sokolskaya - Ph.D. (Med.), cardiologist, Bakoulev Center for CVS (Moscow)
A.Sh. Krymshamkhalova - Post-graduate Student, Bakoulev Center for CVS (Moscow)
Abstract:
Pathogenesis and clinical manifestations of microcirculation disorders are varied. They are especially important in cardiovascular system (CVS) diseases, in which pathogenesis are tissue, overall hemodynamic and endothelial dysfunction. Nowadays, in clinical practice in patients with CVS diseases, is very important the assessment of tissue microcirculation and vasoregulation endothelial function. It is necessary to study the microcirculatory bed for early detection of disease, patient monitoring, prediction of disease outcome, timely appointment of conservative therapy and for control the treatment effectiveness.
One of the important tasks of modern medicine is to find the earliest markers of endothelial structure and function disorders for the prevention of various illnesses. The literature describes many methods of diagnosis of endothelial dysfunction, that are based on different principles. So, the presence of endothelium dysfunction in a patient can be confirmed using a variety of instrumental methods by the analysis of vascular responses during the load tests. One of the methods to evaluate the vasoregulation function of the endothelium is a high-frequency Doppler ultrasound, with the functional occlusion tests.
In this paper is studied the role of high-frequency ultrasound Doppler imaging in assessment of tissue microcirculation and vasoregulation endothelial function in patients with cardiovascular diseases. In study were included 70 patients with ischemic heart diseases, hypertensive disease, multifocal atherosclerosis and control group. The study found that, in the control group response of the microcirculatory bed to the occlusal trial test was appropriate and in the group of patients response was insufficient, that tells about endothelial dysfunction. It is necessary more researches to make a definite conclusion.
Pages: 3-16
References
- Buvalcev V.I.Disfunkcija ehndotelija kak novaja koncepcija profilaktiki i lechenija serdechno-sosudistykh zabolevanijj // Mezhdunarodnyjj medicinskijj zhurnal. 2001. S. 3.
- Voloshin P.V., Malakhov V.A., Zavgorodnjaja A.N. EHndotelialnaja disfunkcija pri cerebrovaskuljarnojj patologii. KHarkov. 2006.
- Vorobeva E.N., SHumakher G.I., KHoreva M.A., Osipova I.V. Disfunkcija ehndotelija - kljuchevoe zveno v patogeneze ateroskleroza // Rossijjkijj kardiologicheskijj zhurnal. 2010. № 2. S. 84.
- Galenko A.S.Ocenka ehndotelialnojj disfunkcii u bolnykh ishemicheskojj boleznju serdca i vozmozhnosti eefarmakologicheskojj korrekcii: Diss. ... kand. med. nauk. SPb. 2005.
- Kozlov V.A., Artjushenko N.K., SHalak O.V. i dr. Ultrazvukovaja doplerografija v ocenke sostojanija gemodinamiki v tkanjakh shei, lica i polosti rta v norme i pri nekotorykh patologicheskikh sostojanijakh // Rukovodstvo-atlas. Sankt-Peterburg. 2000.
- Kozlov V.I., Tupicyn I.O. // Mikrocirkuljacija pri myshechnojj dejatelnosti. Moskva: Fizkultura i sport. 1982. S. 137.
- Kozlov V.I.Dvizhenie krovi po mikrososudam i transkapilljarnyjj obmen. Rukovodstvo po fiziologii: Fiziologija sosudistojj sistemy. L. Nauka: 1984. S. 177-211.
- Tikhomirova I.A., Muravev A.V., Petrochenko E.P., Selezneva O.A., Osljakova A.O. Ocenka gemoreologicheskogo statusa i sostojanija mikrocirkuljacii zdorovykh lic i pacientov s arterialnojj gipertoniejj // Regionalnoe krovoobrashhenie i mikrocirkuljacija. 2009. № 3 (31). S. 37-42.
- Krasnikov V.E. Patofiziologija mikrocirkuljacii i perifericheskogo krovoobrashhenija. Ucheb. pos. Vladivostok. 2013.
- Markova L.I., Kuznecova I.V., Korenkov V.V. i dr. Sostojanie gemodinamiki i mikrocirkuljacii u bolnykh gipertonicheskojj boleznju pri dlitelnom kontroliruemom lechenii lizinoprilom // Kardiologija. 2003. № 12. S. 47-50.
- Makolkin V.I., Ovcharenko S.I., Sulimov V.A. Vnutrennie bolezni. M.: GEHOTAR-Media. 2013. 768 s.
- Markova M.A., CHuchalin A.G., Avdeev S.N. Arterialnaja rigidnost i ehndotelialnaja disfunkcija u pacientov s khronicheskojj obstruktivnojj boleznju legkikh: chto pervichno - // Pulmonologija. 2011. № 6. S. 73-79.
- Mazurov V.I., JAkusheva V.A.EHndotelialnaja disfunkcija pri metabolicheskom sindrome // EHfferentnaja terapija.2006.№ 12 (3).S. 19-24.
- Nikitin JU.M., Trukhanov A.I. // Ultrazvukovaja doplerovskaja diagnostika v klinike. Ivanovo: MIK. 2004. S. 496.
- Petrishhev N.N., Menshutina M.A., Vlasov T.D., Vasina E.JU., Girina M.B., Didur M.D.Kompleks diagnostiki disfunkcii ehndotelija sosudov. SPb.: Patent na poleznuju model № 47202. Prioritet poleznojj modeli 12.04.2005.
- Petrishhev N.N., Vasina E.JU., Korneev N.V., Zaslavskaja M.A., Skedina M.A., Girina M.B.Sposob opredelenija reaktivnosti sosudov mikrocirkuljatornogo rusla i vazomotornojj funkcii ehndotelija s ispolzovaniem vysokochastotnojj doplerografii // Medicinskaja tekhnologija. Sankt-Peterburg: SP-Minimaks. 2009. S. 20.
- Petrishhev H.H., Berkovich O.A., Vlasov T.D. i dr. Diagnosticheskaja cennost opredelenija deskvamirovannykh ehndotelialnykh kletok v krovi // Klinicheskaja laboratornaja diagnostika. 2001. № 1. S. 50-52.
- Polenov S.A. Regionarnoe krovoobrashhenie i mikrocirkuljacija // Osnovy mikrocirkuljacii. 2008. T. 25. № 21. S. 5-19.
- Pokrovskijj V.I., Vinogradov N.A.Oksid azota, ego fiziologicheskie i patofiziologicheskie svojjstva // Terapevticheskijj arkhiv. 2005. № 1. S. 82-87.
- Rebrova O.JU.Statisticheskijj analiz medicinskikh dannykh. M.: Media-Sfera. 2006. S. 305.
- Rodionov R.N., Blokhin I.O., Gagaludza M.M. i dr. Assimetrichnyjj dimetilarginin i ego rol v ehtiologii i patogeneze serdechno-sosudistykh zabolevanijj // Arterialnaja gipertenzija. 2008. T. 14. № 8. S. 306-314.
- Rudenko E.V., Volkov V.S.Ocenka sostojanija mikrocirkuljacii i ehndotelialnojj disfunkcii u bolnykh sakharnym diabetom 2 tipa s soputstvujushhejj arterialnojj gipertoniejj s pomoshhju apparata «Minimaks-Dopler-K». Tver. 2011.
- Rudenko E.V. Funkcionalnoe sostojanie arterioljarnogo krovotoka u bolnykh s arterialnojj gipertoniejj, razvivshejjsja na fone sakharnogo diabeta 2 tipa. Tver. 2008.
- Seleznev S.A., Petrishhev N.N. Osnovnye istoricheskie ehtapy nauchnojj razrabotki ... . SPb.: Izdatelstvo SPbGMU. 1998. S. 16-20; 7-8.
- Sirotin B.Z., ZHmereneckijj K.V.Mikrocirkuljacija priserdechno-sosudistykh zabolevanijakh. KHabarovsk: Dalne-vostochnyjj gosudarstvennyjj medicinskijj universitet. 2008.
- Sushkina I.F., Sagakova G.A., SHlyk S.V.Ocenka vazomotornojj funkcii ehndotelija pri provedenii funkcionalnykh probu pacientov s ishemicheskojj boleznju serdca i prakticheski zdorovykh lic raznogo vozrasta // Rossijjskijj kardiologicheskijj zhurnal. 2014. № 5 (109). Prilozhenie 1. S. 114-115.
- Taskina V.JU.Regionarnyjj mozgovojj krovotok i mikrocirkuljacija u pacientov s fibrilljaciejj predserdijj v rannem posleoperacionnom periode. Avtoreferat. Moskva. 2014.
- SHishkin A.N.Sovremennaja strategija terapii ehndotelialnojj disfunkcii s pozicijj dokazatelnojj mediciny // Vrachebnye vedomosti. 2008. № 3 (45). S. 6-19.
- WHO GlobalInfoBase (http:www.infobase.who.int).Strategija profilaktiki i kontrolja neinfekcionnykh zabolevanijj i travmatizma v Rossijjskojj Federacii. Moskva. 2008.
- Alderton W.K., Cooper C.E., Knouwles R.G.Nitric oxide syntheses: structure, function and inhibition // Biochemical Journal. 2001.№ 357 (4).R. 593-615.
- Bulatova I.A., Shchekotova A.P., Tret-yakovaYu.I.Endothelial dysfunction in chronic diffuse liver diseases // Kazanskiy meditsinskiy zhurnal. 2009.№ 90 (1).R. 46-8 (in Russian).
- Cai H., Harrison D.G. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress // Circ Res. 2000. № 87(10). P. 840-844.
- Chennupati R., Lamers W.H, Koehler S.E., De Mey J.G. Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes // Br. J. Pharmacol. 2013. V. 169 (7).P.1486-1499.
- Feletou M., Vanhoutte P.M.Endothelial dysfunction: a multifaceted disorder / Am. J. Physiol. Heart Circ. Physiol. 2006.№ 21.R. 377-85.
- Furchgott R.F., Zawadzki J.V. The obligatory role of the endothelial cells in relaxation of arterial smooth muscle by acetylcholine // Nature. 1980.№ 288. P. 373-376.
- Gokce N., KeaneyJ.F.Jr, Hunter L.M. et al. // Predictive value ofnoninvasively determined endothelial dysfunction for longtermcardiovascular events in patients with peripheral vasculardisease // J. Am. Coll. Cardiol. 2003. № 41 (10). R. 1769-1775.
- Halcox J.P. Jr, Schenke W.H., Zalos G. et al. Prognostic value ofcoronary vascular endothelial dysfunction // Circulation. 2002. № 106 (6).R. 653-658.
- Ibsen H., Olsen M.H., Wachtell K., et al. Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study // Hypertension. 2005. № 45. R. 198-202.
- Luscher T.F., Boulanger C.M., Dohi Y., Yang Z.H. Jean Baptiste Michel. NO (Nitric oxide) and Cardiovascular Homeostasis 1999 Menarini International Industrie Farmaceutiche Riunites. r. l. Paris // Endothelium-derived contracting factors. Hypertension. 1992 Feb.№ 19 (2).R. 11730.
- Landmesser U., Harrison D.G., Drexler H.Oxidant stress ? amajor cause of reduced endothelial nitric oxide availability incardiovascular disease // Eur. J. Clin. Pharmacol. 2006. 62(Suppl. 13). P. 13-19.
- Maas R. Pharmacotherapy-s and their influence on ADMA // Vasc Med. 2005-2010. Suppl 1. P. 49-57.
- McVeigh G., Lemay., Morgan D., Cohn J. Effects of long-term cigarette smoking on endothelium-dependent responses in humans // Am. J. Cardiology. 1996. V. P. 668-672.
- Migliacci R., Falcinelli F., Imperiali P.Endothelial dysfunctionin patients with kidney failure and vascular risk factors: acuteeffects of hemodialysis // Ital. Heart. J. 2004.№ 5 (5).R. 371-377.
- Patti G., Melfi R., Di Sciascio G.The role of endothelial dysfunctionin the pathogenesis and in clinical practice of atherosclerosis. Current evidences //RecentiProg. Med. 2005.№ 96 (10). R. 499-507.
- Pepine C.J., Celermajer D.S., Drexler H. Vascular health as a therapeutic tagert in cardiovascular disease // University of Florida. 1998. P.45-53.
- Schmid-Schonbein G.W.,Durán W., Pappas P.J. Microcirculatory inflammation in chronic venous insufficiency: current status and future directions // Microcirculation. 2000.V. 7 .№6 (Pt. 2). P. 49 - 58.
- Tibirisa E., Rodrigues E., Cobas R.A., Gomes M.V.Endothelialfunction in patients with type 1 diabetes evaluated by skin capillaryrecruitment. Microvascular Research. 2007. 73 (Issue 2). R. 107-112.
- Zeiher A.M., Krause T., Schachinger V. et al. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia // Circulation. 1995. 91. R. 2345-2352.