Potential carcinogenicity study of antibacterial drug Sanguiritrin

L.V. Krepkova; V.V. Bortnikova; O.N. Тоlkachev; А.А. Shkarenkov; А.А. Веloshapkо

Potential carcinogenicity study of antibacterial drug Sanguiritrin

L.V. Krepkova¹, V.V. Bortnikova², O.N. Тоlkachev³, А.А. Shkarenkov⁴, А.А. Веloshapkо⁵

research article Pages: 4-9

¹ к.б.н., зав. отделом токсикологии, ГНУ ВИЛАР Россельхозакадемии (Москва)
² к.б.н., вед. науч. сотрудник, лаборатория лекарственной токсикологии, ГНУ ВИЛАР Россельхозакадемии
³ д.х.н., профессор, гл. науч. сотрудник, отдел фитохимии, ГНУ ВИЛАР Россельхозакадемии
^4,5 к.м.н., ГНУ ВИЛАР Россельхозакадемии

Keywords: carcinogenicity properties Sanguiritrin Macleaya alkaloids

Abstract

Experimental and potential carcinogenicity properties of the antimicrobial phytodrug Sanguiritrin, isolated from Macleaya cordata (Willd.) R.Br.) and Macleaya microcarpa (Maxim.) Fedde (Papaveraceae) have been studied. Two series testing were applied in experiments on pubertal mice: the drug was used on epicuteneous banding over the life duration, while 40 % alcogol was used as the control. The drug was applied on the clipping part of the skin. In the second series of tests there were studied promotеr action of Sanguiritrin, while 7,12-dimethylbeng[a]antracene (7,12-DMBA) was used as the carcinogenе, on epicuteneous application following, treatment with drug after 2 weeks similar to that as in previons the example.

Тhere were shown that the latent period of tumor growth, a number of tumors of the animals got the Sanguiritrin were not exceeded even the control parametrs.

Thus the results produced are testified that the drug Sanguiritrin have not carcinogenicity properties during the life duration application аnd the latter is not the carcinogenicity promoter.

How to cite

Крепкова Л.В., Бортникова В.В., Толкачев О.Н., Шкаренков А.А., Белошапко А.А. Изучение потенциальных канцерогенных свойств антимикробного средства Сангвиритрин // Вопросы биологической, медицинской и фармацевтической химии. 2013. № 4. С. 4–9.

References

Vichkanova S.A., Kolkhir V.K., Sokolskaja T.A., Voskobojjnikova I.V., Bykov V.A.Lekarstvennye sredstva iz rastenijj. M.: Adris. 2009. S. 246-261.
Bortnikova V.V. Sravnitelnaja toksikologicheskaja kharakteristika i novye farmakologicheskie svojjstva antimikrobnykh i protivovirusnykh preparatov rastitelnogo proiskhozhdenija: Avtoref. dis. ... kand. biol. nauk. Kupavna. 1988. 21 s.
Bortnikova V.V., Krepkova L.V., Arzamascev E.V., Kuznecov JU.B., Borovkova M.V. Protivovospalitelnye svojjstva nekotorykh rastitelnykh antimikrobnykh i protivovirusnykh preparatov // Sb. nauchn. trudov VILAR: KHimija, tekhnologija, medicina. M. 2000. S. 369-375.
Krepkova L.V., Bortnikova V.V., SHkarenkov A.A., Kuznecov JU.B., Borovkova M.V. Doklinicheskoe izuchenie bezopasnosti novojj lekarstvennojj formy sangviritrina obshherezorbtivnogo dejjstvija // Sb. nauchn. trudov VILAR: KHimija, tekhnologija, medicina. M. 2003. S. 215-226.
Psotova J., Vecera R., Zdarilova A., Anzenbacherova E., Kosina P., Svobodova A., Hrbac J., Jirovsky D., Stiborova M., Lichnovsky V., Vicar J., Simanek V., Ulrichova J. Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats // Veterinarni Medicina. 2006. V. 51. № 4. R. 145-155.
Stiborova M., Vostalova J., Zdarilova A., Ulrichova J., Hudecek J., Tschirner K., Simanek V. Macleay cordata extract and Sangrovit^®Genotoxicity. Assessment in vivo // Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008. V. 152 № 1. R. 35-39.
Zdarilova A.,Vrublova E., Vostalova J., Klejdus B., Stejskal D.,Proskova J., Kosina P., Svobodova A., Vecera R., Hrbac J.,Sernochova D.,Vicar J., Ulrichova J., Simanek V. Natural feed additive of Macleay cordata. Safety assessment in rats a 90-day feeding experiment // JavaScript required for article outline. V. 46, issue 12, December 2008. P. 3721-3726.
Malikova J., Zdarilova A., Hlobikova A. Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis // Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006. V. 150. № 1. R. 5-12.
Pylev L.N., Turusov V.S., Syrkin A.B., Pliss G.B., Guskova T.A., Ljubimov B.I., Vasileva L.A., SHashkina L.F. Metodicheskie ukazanija po izucheniju kancerogennykh svojjstv farmakologicheskikh veshhestv i lekarstvennykh sredstv // Rukovodstvo po ehksperimentalnomu (doklinicheskomu) izucheniju novykh farmakologicheskikh veshhestv. M.: 2000. S. 61-65.
Vasilev JU.M., Gelshtejjn V.I., Presnov M.A. Opukholi, vyzyvaemye khimicheskimi kancerogennymi veshhestvami // Sb. statejj «Modeli i metody ehksperimentalnojj onkologii». M. 1960. S. 54-85.
SHabad L.M. Predrak v ehksperimentalno-morfologicheskom aspekte. M. 1967. S. 10-38.
LakinG.F.Biometrija. M. 1990. S.113-131.

[1] Vichkanova S.A., Kolkhir V.K., Sokolskaja T.A., Voskobojjnikova I.V., Bykov V.A.Lekarstvennye sredstva iz rastenijj. M.: Adris. 2009. S. 246-261.

[2] Bortnikova V.V. Sravnitelnaja toksikologicheskaja kharakteristika i novye farmakologicheskie svojjstva antimikrobnykh i protivovirusnykh preparatov rastitelnogo proiskhozhdenija: Avtoref. dis. ... kand. biol. nauk. Kupavna. 1988. 21 s.

[3] Bortnikova V.V., Krepkova L.V., Arzamascev E.V., Kuznecov JU.B., Borovkova M.V. Protivovospalitelnye svojjstva nekotorykh rastitelnykh antimikrobnykh i protivovirusnykh preparatov // Sb. nauchn. trudov VILAR: KHimija, tekhnologija, medicina. M. 2000. S. 369-375.

[4] Krepkova L.V., Bortnikova V.V., SHkarenkov A.A., Kuznecov JU.B., Borovkova M.V. Doklinicheskoe izuchenie bezopasnosti novojj lekarstvennojj formy sangviritrina obshherezorbtivnogo dejjstvija // Sb. nauchn. trudov VILAR: KHimija, tekhnologija, medicina. M. 2003. S. 215-226.

[5] Psotova J., Vecera R., Zdarilova A., Anzenbacherova E., Kosina P., Svobodova A., Hrbac J., Jirovsky D., Stiborova M., Lichnovsky V., Vicar J., Simanek V., Ulrichova J. Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats // Veterinarni Medicina. 2006. V. 51. № 4. R. 145-155.

[6] Stiborova M., Vostalova J., Zdarilova A., Ulrichova J., Hudecek J., Tschirner K., Simanek V. Macleay cordata extract and Sangrovit^®Genotoxicity. Assessment in vivo // Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008. V. 152 № 1. R. 35-39.

[7] Zdarilova A.,Vrublova E., Vostalova J., Klejdus B., Stejskal D.,Proskova J., Kosina P., Svobodova A., Vecera R., Hrbac J.,Sernochova D.,Vicar J., Ulrichova J., Simanek V. Natural feed additive of Macleay cordata. Safety assessment in rats a 90-day feeding experiment // JavaScript required for article outline. V. 46, issue 12, December 2008. P. 3721-3726.

[8] Malikova J., Zdarilova A., Hlobikova A. Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis // Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006. V. 150. № 1. R. 5-12.

[9] Pylev L.N., Turusov V.S., Syrkin A.B., Pliss G.B., Guskova T.A., Ljubimov B.I., Vasileva L.A., SHashkina L.F. Metodicheskie ukazanija po izucheniju kancerogennykh svojjstv farmakologicheskikh veshhestv i lekarstvennykh sredstv // Rukovodstvo po ehksperimentalnomu (doklinicheskomu) izucheniju novykh farmakologicheskikh veshhestv. M.: 2000. S. 61-65.

[10] Vasilev JU.M., Gelshtejjn V.I., Presnov M.A. Opukholi, vyzyvaemye khimicheskimi kancerogennymi veshhestvami // Sb. statejj «Modeli i metody ehksperimentalnojj onkologii». M. 1960. S. 54-85.

[11] SHabad L.M. Predrak v ehksperimentalno-morfologicheskom aspekte. M. 1967. S. 10-38.

[12] LakinG.F.Biometrija. M. 1990. S.113-131.

Abstract

How to cite

Related articles