The use of nmr methods in studies of glial tumors at laboratory animals

Н.В. Анисимов; Г.М. Юсубалиева; Н.А. Брусенцо; А.А. Самойленко; Ю.А. Пирогов

The use of nmr methods in studies of glial tumors at laboratory animals

Н.В. Анисимов¹, Г.М. Юсубалиева², Н.А. Брусенцо³, А.А. Самойленко⁴, Ю.А. Пирогов⁵

research article Pages: 35-40

¹ д.ф.-м.н., ст. науч. сотрудник, факультет фундаментальной медицины, МГУ им. М.В.Ломоносова
² к.м.н., ст. науч. сотрудник, Институт судебной психиатрии (ГНЦ ССП) им. М.В. Сербского (Москва)
³ д.ф.н., вед. науч. сотрудник, Российский онкологический научный центр им. Н.Н. Блохина РАМН (Москва)
⁴ к.х.н., зав. лабораторией, Институт химической физики им. Н.Н. Семёнова РАН (Москва)
⁵ д.ф.-м.н., профессор, физический факультет, МГУ им. М.В.Ломоносова

Keywords: magnetic resonance imaging NMR spectroscopy glioma laboratory animals contrast agents bioactive substances

Abstract

It is reported on the application of magnetic resonance methods - NMR spectroscopy and MR imaging (in magnetic field 7 Tesla) for the study of glial tumors in their simulation in laboratory animals - mouses and rats. There are given an examples of spectral analysis, relaxation measurements, MR visualisation, the use of contrast agents and bioactive substances.

How to cite

Анисимов Н.В., Юсубалиева Г.М., Брусенцо Н.А., Самойленко А.А., Пирогов Ю.А. Применение методов ЯМР в исследованиях глиальных опухолей у лабораторных животных // Технологии живых систем. 2013. № 1. С. 35–40.

References

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[1] Grobben B., De Deyn P.P., Slegers H. Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion // Cell Tissue Res. 2002. V. 310 (3). P. 257-270.

[2] Wickline S.A., Neubauer A.,M., Winter P.M., Carusels S.D., Lanza G.M. Molecular imaging and therapy of atherosclerosis with targeted nanoparticles // JMRI/ 2007. V. 25 (4). P. 667-680.

[3] Brusentsov N.A., Pirogov Y.A., Anisimov N.V., Polianski V.A., Lichinicer M.R., Golubeva I.S., Gulyaev M.V., Nikitin M.P., Brusentsova T.N., Nikitin P.I., VerkhoglazovaE.V. Combined MRI-adaptive Magneto-thermo-polychemotherapy for Improved Cancer Treatment// Am. Inst. Phys. 2010. V. 1311. P. 447-452.

[4] Howe F.A., Barton S.J., Cudlip S.A., Stubbs M., Saunders D.E., Murphy M., Wilkins P., Opstad K.S., Doyle V.L., McLean M.A., Bell B.A., Griffiths J.R. Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy // Magn. Reson. Med. 2003. V. 49(2). P. 223-232.

[5] Maintz D., Heindel W., Kugel H., Jaeger R., Lackner K.J. Phosphorus-31 MR spectroscopy of normal adult human brain and brain tumours // NMR Biomed. 2002. V. 15 (1). P. 18-27.

[6] Zwingmann C., Leibfritz D. Regulation of glial metabolism studied by 13C-NMR // NMR Biomed. 2003. V. 16(6-7). P. 370-399.

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