N.R. Isaev1

1 Institute for Bionic Technologies and Engineering, Sechenov First Moscow State Medical University (Sechenov University) (Moscow, Russia)

1 isaev_n_r@staff.sechenov.ru

The application of most modern neuroimplants is limited by their rigidity, low biocompatibility, and the need for wired connections. One of the relevant directions in neurotechnology is the development of implants with technical and technological characteristics as close as possible to human cells, tissues, and organs. This approach minimizes immune response, prevents mechanical damage, and ensures biological feedback, thereby expanding the application of neuroimplants in medical practice.

Aim of the study – development of a thin-film technology platform based on parylene C using multi-electrode structures, with the ability to modify it for precise recording of neural activity signals and localized stimulation.

A flexible multi-electrode system for neurostimulation and biosensing has been developed. The obtained implants are characterized by high flexibility and the ability to achieve conformal contact with tissues, as well as the possibility of modifying stimulating structures to increase the efficiency of neurostimulation and signal registration.

The proposed concept provides a foundation for the development of a new generation of flexible neurostimulators. Such devices can overcome key limitations of traditional rigid electrodes, such as pronounced foreign body response, increased impedance, and rapid signal degradation.

Isaev N.R. Development of flexible multi-electrode arrays for neural signal recording and stimulation // Biomedical Radioelectronics. 2026. V. 29. № 6. P. 49−54. DOI: https://doi.org/10.18127/j15604136-202606-10

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