Е.С. Герштейн – д.б.н., профессор, Национальный медицинский исследовательский  центр онкологии им. Н.Н. Блохина(Москва)

Н.Е. Кушлинский – д.м.н., профессор, чл.-корр. РАН, Национальный медицинский 

исследовательский центр онкологии им. Н.Н. Блохина (Москва)

E-mail: biochimia@yandex.ru

Представлены данные литературы и собственных исследований, свидетельствующие о том, что растворимая форма KIM-1 (kidney injury molecule – маркер/молекула/повреждения почек) – специфического маркера поражения тубулярного эпителия почек при различных заболеваниях, ассоциированных с почечной недостаточностью, и при нефротоксических воздействиях различной природы – является потенциальным высокочувствительным маркером для раннего выявления почечно-клеточного рака. Подробно охарактеризованы особенности строения KIM-1, молекулярный механизм его действия, а также изменения в его экспрессии, происходящие при неонкологических заболеваниях почек.

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