М.В. Лекишвили - д.м.н., зав. лабораторией «тканевой банк», ФГБУ Центральный институт травматологии и ортопедии им. Н.Н. Приорова Минздрава РФ (Москва). E-mail: leki@mail.ru. Е.Д. Склянчук - д.м.н., профессор, кафедра травматологии, ортопедии, Московский государственный медико-стоматологический университет. E-mail: drevg@mail.ru А.Ю. Рябов - к.м.н., ведущий челюстно-лицевой хирург, Стоматологический центр «Интердентос» и ООО «Медбиолек» Ю.Б. Юрасова - д.м.н., зав. отделением нефрологии, Российская детская клиническая больница (Москва) А.А. Очкуренко - д.м.н., профессор, руководитель организационно-методического отдела, ФГБУ Центральный институт травматологии и ортопедии им. Н.Н. Приорова Минздрава РФ. E-mail: rmapo-cito@mail.ru

По литературным источникам рассмотрены вопросы и проблемы местного использования бисфосфонатов с целью усиления фиксации эндопротезов на экспериментальных моделях. Проанализированы данные различных исследований с перспективой внедрения местного применения бисфосфонатов в клиническую практику челюстно-лицевой хирургии, травматологии и ортопедии.

 

1. Abtahi J., Agholme F., Sandberg O., Aspenberg P. Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw // J. Dental Research. 2013. V.92. №3. P. 279-283.
2. Aspenberg P., Astrand J.Bone allografts pretreated with a bisphosphonate are not resorbed// Acta Orthop Scand. 2002. V.73. №1. P. 20-23.
3. Aspenberg P.Bisphosphonates and implants// Acta Orthop. 2009. V.80. №1. P. 119-123.
4. Astrand J., Aspenberg P. Alendronate did not inhibit instability-induced bone resorption. A study in rats // Acta Orthop Scand. 1999. V.70. №1. P. 67-70.
5. Astrand J., Aspenberg P.Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening // J. Orthop Res. 2004. V.22. №2. P. 244-249.
6. Åberg J., Brohede U., Mihranyan A. et al. Targeted local delivery of bisphosphonate from orthopaedic implants // Key Engineering Materials (Ed. M. Prado and C. Zavaglia). 2008. Bioceramics 21. P. 543-546.
7. Åberg J., Brohede U., Mihranyan A. et al.Bisphosphonate incorporation in surgical implant coatings by fast loading and co-precipitation at low drug concentrations // J. Mater. Sci Mater Med. 2009. V. 20. № 10. P. 2053-2061.
8. Agholme F., Aspenberg P. Experimental results of combining bisphosphonates with allograft in a rat model // J. Bone Jt. Surg. (Br). 2009. V.91. № 5. P. 670-675.
9. Back D.A., Pauly S., Romme L. et al. Effect of local zoledronate on implant osseointegration in a rat model // BMC Musculoskeletal Disorders. 2012. P. 13-42.
10. Bauer T.W., Smith S.T. Bioactive materials in orthopaedic surgery: overview and regulatory considerations // Clin. Orthop. 2002. № 395. P. 11-22.
11. Bhandari M., Bajammal S., Guyatt G.H. et al. Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty. A meta-analysis // J. Bone Jt. Surg. (Am). 2005. V.87. № 2. P. 293-301.
12. Bobyn J.D., Hacking S.A., Krygier J.J. et al. Zoledronic acid causes enhancement of bone growth into porous implants // J. Bone Jt. Surg. (Br). 2005. V.87. № 3. P.416-420.
13. Bosemark P., Isaksson H., McDonald M.M. et al.Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength // Acta Orthop. 2013. V. 84. № 1. P. 106-111.
14. Chacon G.E., Stine E.A., Larsen P.E. et al.Effect of alendronate on endosseous implant integration: an in vivo study in rabbits // J. Oral Maxillofac Surg. 2006. V.64. № 7. P. 1005-1009.
15. Ding M.,Day J.S., BurrD.B. et al.Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates// Calcified Tissue Int. 2003.V.72. № 6. P. 737-744.
16. DiResta G.R., Manoso M.W., Naqvi A. et al.Bisphosphonate delivery to tubular bone allografts // Clin. Orthop. 2008. № 466. P. 1871-1879.
17. Faucheux C., Verron E., Soueidan A. et al. Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro // J. Biomed Mater. Res. 2009. V.89A. № 1. P. 46-56.
18. Fleisch H. Bisphosphonates in bone disease // International publishers in Medicine, Science&Technology, New York. 1997. 173 p.
19. Frenkel S.R., Jaffe W.L., Valle C.D. et al. The effect of alendronate (Fosamax) and implant surface on bone integration and remodeling in a canine model // J. Biomed. Mater. Res. 2001. V.58. № 6. P. 645-650.
20. Gangoiti M.V., Cortizo A.M., Arnol V. et al.Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells // Eur. J. Pharmacol. 2008. V.600. № 1-3. P. 140-147.
21. Gao Y., Zou S., Liu X. et al.The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats // Biomaterials. 2009. V.30. № 9. P. 1790-1796.
22. Garbuz D.S., Hu Y., Kim W.Y. et al.Enhanced gap filling and osteoconduction associated with alendronate-calcium phosphate-coated porous tantalum // J. Bone Jt. Surg. (Am). 2008. V.90. № 5. P. 1090-1100.
23. Greiner S.H., Kadow-Romacker A., Lubberstedt M. et al. The effect of zoledronic acid incorporated in a poly(D,L-lactide) implant coating on osteoblasts in vitro // J. Biomed. Mater. Res. 2006. V.80A. № 4. P. 769-775.
24. Greiner S.H., Kadow-Romacker A., Wildemann B. et al.Bisphosphonates incorporated in a poly(D,L-lactide) implant coating inhibit osteoblast like cells in vitro // J. Biomed. Mater. Res. 2007. V.83A. № 4. P. 1184-1191.
25. Greiner S.H., Wildemann B., Back D.A. et al. Local application of zoledronic acid incorporated in a poly(D,L-lactide) coated implant accelerates fracture healing in rats // Acta Orthop. 2008. V.79. № 5. P. 717-725.
26. Harding A.K., Aspenberg P., Kataoka M. et al.Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate // J. Orthop Res. 2008. V.26. № 9. P. 1245-1249.
27. Hilding M., Aspenberg P. Postoperative clodronate decrease prosthetic migration: 4-yer follow-up of a randomized radiostereometric study of 50 total knee patients // Acta Orthop. 2006. V.77. № 6. P. 912-916.
28. Hilding M., Aspenberg P. Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: a randomized, double-blind radiostereometric study of 50 
29. patients // Acta Orthop. 2007. V.78. № 6. P. 795-799.
30. Hu J.H., Ding M., Søballe K. et al. Effects of short-term alendronate treatment on the three-dimensional microstructural, physical, and mechanical properties of dog trabecular bone // Bone. 2002. V.31. № 5. P. 591-597.
31. Jakobsen T., Kold S., Bechtold J.E. et al. Effect of topical alendronate treatment on fixation of implants inserted with bone compaction // Clin. Orthop. 2006. № 444. P. 229-234.
32. Jakobsen T., Baas J., Bechtold J.E. et al. Soaking morselized allograft in bisphosphonate can impair implant fixation // Clin. Orthop. 2007. № 463. P. 195-201.
33. Jakobsen T., Kold S., Bechtold J.E. et al. Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study // J. Orthop. Res. 2007. V.25.№ 4. P. 432-441.
34. Jakobsen T., Baas J., Kold S. et al. Local bisphosphonate treatment increases fixation of hydroxyapatite-coated implants inserted with bone compaction // J. Orthop. Res. 2009. V.27.№ 2. P. 189-194.
35. Jakobsen T., Baas J., Bechtold J.E. et al. The effect of soaking allograft in bisphosphonate // Clin. Orthop. 2010. № 468. P. 867-874.
36. Jakobsen T., Baas J., Bechtold J.E. et al. The effect on implant fixation of soaking tricalcium phosphate granules in bisphosphonate // Open Orthop. J. 2012. V.6. P. 371-375.
37. Jensen T.B., Bechtold J.E., Chen X., Søballe K.Systemic alendronate treatment improves fixation of press-fit implants: a canine study using nonloaded implants // J. Orthop. Res. 2007. V.25. № 6. P. 772-778.
38. Jeppsson C., Ǻstrand J., Tägil M., Aspenberg P. A combination of bisphosphonate and BMP additives in impacted bone allografts // Acta Orthop. Scand. 2003. V.74. № 4. P. 483-489.
39. Kanis J.A., Adams J., Borgstrom F. et al. The cost-effectiveness of alendronate in the management of osteoporosis // Bone. 2008. V.42. № 1. P. 4-15.
40. Matuszewski Ł., Turżańska K., Matuszewska A. et al.Effect of implanted bisphosphonate-enriched cement on the trabecular microarchitecture of bone in a rat model using micro-computed tomography // Int. Orthopaed (SICOT). 2013. V.37. P. 1187-1193.
41. Meraw S.J., Reeve C.M., Wollan P.C. Use of alendronate in peri-implant defect regeneration // J. Periodontol. 1999. V.70. № 2. P. 151-158.
42. McKenzie K., Dennis Bobyn J., Roberts J. et al.Bisphosphonate remains highly localized after elution from porous implants // Clin. Orthop. 2011. V.469. № 2. P. 514-522.
43. Millett P.J., Allen M.J., Bostrom M.P. Effects of alendronate on particle-induced osteolysis in a rat model // J. Bone Jt. Surg. (Am). 2002. V.84. № 2. P. 236-249.
44. Nakamura O., Kaji Y., Imaizumi Y. et al.Prefabrication of vascularized bone allograft in a recipient rat using a flow-through vascular pedicle, bone morphogenetic protein, and bisphosphonate // J. Reconstr. Microsurg. 2013. V.29. № 4. P. 241-248.
45. Nishioka T., Yagi S., Mitsuhashi T. et al. Alendronate inhibits periprosthetic bone loss around uncemented femoral components // J. Bone Miner. Metab. 2007. V.25. № 3. P. 179-183.
46. Ozturk A.M., Tabak A.Y., Aktekin C.N. et al. Alendronate enhances antibiotic-impregnated bone grafts in the treatment of osteomyelitis // Int. Orthopaed. 2008. V.32. № 6. P. 821-827.
47. Peter B., Ramaniraka N., Rakotomanana L.R. et al.Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis // Comput Methods Biomech. Biomed. Engin. 2004. V.7. № 2. P. 73-78.
48. Russell R.G.G., Watts N.B., Ebetino F.H., Rogers M.J.Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy// Osteoporosis Int. 2008. V.19. № 6. P. 733-759.
49. Shanbhag A.S. Use of bisphosphonates to improve the durability of total joint replacements// J. Am. Academy Orthop. Surg. 2006. V.14. № 4. P. 215-225.
50. StadelmannV.A., TerrierA., Gauthier O. et al. Prediction of bone density around orthopedic implants delivering bisphosphonate // J. Biomechanics. 2009. V.42. № 9. P. 1206-1211.
51. Søballe K., Chen X., Jensen T.B. et al.Alendronate treatment in the revision setting, with and without controlled implant motion: an experimental study in dogs // Acta Orthop. 2007. V.78. № 6. P. 800-807.
52. Tanzer M., Karabasz D., Krygier J.J. et al. Bone augmentation around and within porous implants by local bisphosphonate elution // Clin. Orthop. 2005. № 441. P. 30-39. von Knoch F., Eckhardt C., Alabre C.I. et al.Anabolic effects of bisphosphonates on peri-implant bone stock // Biomaterials. 2007. V.28. № 24. P. 3549-3559.
53. Xue Q., LiH., Zou X. et al.Healing properties of allograft from alendronate-treated animal in lumbar spine interbody cage fusion // European Spine J. 2005. V.14. № 3. P. 222-226.