А.П. Соковикова1, М.В. Гуляев2, Ю.А. Пирогов3

1–3 Московский государственный университет имени М.В. Ломоносова (Москва, Россия)

Постановка проблемы. Представлен аналитический обзор публикаций, посвященных исследованию метаболических процессов в мышечных тканях посредством спектроскопии ядерного магнитного резонанса (ЯМР).

Цель работы – рассмотрение и оценка методов протонной и фосфорной ЯМР-спектроскопии как неинвазивного аналога биопсии при изучении патологий мышечной ткани.

Результаты. Выполнен аналитический обзор статей, в которых рассматривается применение ЯМР-спектроскопии в диагностике таких патологий мышечной ткани, как миопатия Дюшенна, миотоническая дистрофия, сахарный диабет и сердечная недостаточность. Особое внимание уделяется рассмотрению молекулярных процессов, протекающих в разнообразных мышечных тканях с участием метаболических превращений карнозина, креатина, липидов и фосфорсодержаших метаболитов. Описаны также диагностические методы протонной и фосфорной ЯМР-спектроскопии при анализе состояния здоровья людей при физических нагрузках.

Практическая значимость. Выводы данной статьи могут применяться в лабораторных и клинических исследованиях мышечных патологий, а также в ходе наблюдения за состоянием здоровья спортсменов при нормальной и критически предельной физической нагрузке организма.

Соковикова А.П., Гуляев М.В., Пирогов Ю.А. Изучение метаболических процессов в мышечных тканях методом спектроскопии ядерного магнитного резонанса // Биомедицинская радиоэлектроника. 2022. T. 25. № 2. С. 58-65. DOI: https://doi.org/ 10.18127/j15604136-202202-06

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