350 руб
Журнал «Вопросы биологической, медицинской и фармацевтической химии» №6 за 2015 г.
Статья в номере:
Фитопрепараты эвкалипта (Eucalyptus) и эхинацеи (Echinacea) в терапии воспалительных заболеваний полости рта
Ключевые слова:
эвкалипт
эхинацея
воспалительно-деструктивные заболевания полости рта
антимикробное
противовоспалительное
им-муностимулирующее действие
Авторы:
П.М. Масесе - аспирант, кафедра общей фармацевтической и биомедицинской технологии, Российский университет дружбы народов (Москва). E-mail: pet_masese@yahoo.com
П.Г. Мизина - д.фарм.н., зав. научно-организационным отделом, Всероссийский научно-исследовательский институт лекарственных и ароматических растений; профессор, кафедра общей фармацевтической и биомедицинской технологии, Российский университет дружбы народов (Москва). E-mail: mizina-pg@yandex.ru
С.Н. Суслина - к.фарм.н., доцент, зав. кафедрой общей фармацевтической и биомедицинской технологии, Российский университет дружбы народов (Москва). E-mail: svetlana-suslina@yandex.ru
Т.Ю. Владимирова - к.м.н., доцент, кафедра оториноларингологии имени академика И.Б. Солдатова, Самарский государственный медицинский университет. E-mail: vladimirovalor@ya.ru
Аннотация:
Лекарственные растения являются неистощимым источником эффективных и безопасных биологически активных веществ. Они служат базой для разработки новых антимикробных лекарственных средств, для которых быстрое развитие к последним лекарственной резистентности микроорганизмов не характерно. Эти препараты отличаются от синтетических наличием противовоспалительных или других дополнительных лечебных свойств, а также хорошей переносимостью в терапевтических дозах.
Современный уровень накопленных знаний в области антибиотикотерапии позволяет прогнозировать их широкое использование в этой области и в будущем, несмотря на резистентность многих штаммов микроорганизмов к антибиотическим препаратам. Внедрение в клиническую практику новых групп антибактериальных препаратов не решает проблему лекарственной устойчивости или ослабляет её лишь на короткое время. Кроме того, антибактериальные препараты могут оказывать токсическое действие на жизненно важные органы и подавлять нормальную микрофлору человека, что приводит к развитию дисбактериоза. В связи с этим, значимость лекарственных фитопрепаратов не ослабевает до настоящего времени. Примером таких фитопрепаратов являются препараты эвкалипта и эхинацеи, которые обладают широким спектром фармакологического действия и широко используются при лечении воспалительных заболеваний полости рта.
Страницы: 35-41
Список источников
- Abramycheva N.V., Shaydullin G.G., Bashirova R.M., Yamaleev A.A., Nikitina T.I. Evaluation of immune activity of an ekhinatsea of purple Echinacea purpurea (L.) Moench., grown up in Bashkortostan // Studying and use of an ekhinatsea: Materials from international scientific confrence. Poltava. 1998. P. 97-100.
- Akulich I.I. Use of Imudon after tonsillectomy // Messenger of otorhinolaryngology. 2006. № 6. P. 57-58.
- Arefyeva N.A. Immunological aspects of otorhinolaryngology // News of otorhinolaryngology and logopathology. 1997. № 4. P. 3-9.
- The atlas Russia-s medical plants / revised edition by academician V.A. Bykov. M. 2006. P. 335-337.
- Ashikhmin Ya. New prospects of using echinacea medicines // Doctor. 2010. № 1. P. 32-34.
- Belov B.S. A-streptococcal tonsillitis: modern aspects of antibacterial therapy // Pediatric pharmacology. 2007. V. 4. № 3. P. 58-66.
- Belov B.S., Nasonova V.A., Grishayeva T.N., Sidorenko S.V. Sharp rheumatic fever and A-streptococcal tonsillitis: current state of the problem, antibiotic-therapy questions // Antibiotic and chemotherapy. 2000. V. 45. № 4. P. 22-27.
- Butt G. Advantages of using complex plant components to treat diseases affecting ENT organs of http://www.health-ua.org/archives/health/503.html
- Velmyaykina E.I. Pharmacological research on echinacea purple as a source of medicine for immunodeficience // Diss. ?. edging. Pharm. sciences. Samara. 2013. P.20-25.
- Vichkanova S.A. Medicines from plants. M. 2009. P. 347 - 370.
- Vichkanova S.A. New aspects of using eucalimin // Biological, medical and pharmaceutical chemistry questions. 2012. № 1. P. 214-220.
- Voitenko G.M., Lasitsa O.I., Yakovleva N.Yu. etc. Use of tincture of an echinacea purple in pediatric practice // Study and use of an echinacea: Materials from international scientific confrence. Poltava. 1998. P. 108-109.
- Volkov A.V. Immunomodulatory therapy in chronic tonsillitis // Russian medical magazine. 2010. V. 18. № 2. P. 90-92.
- State pharmacopeia of the USSR, 11 edition, series 2. P. 257-258.
- Hoffman of V.V. State of immune system in acute and chronic diseases of ENT organs // State of Immunodeficiency. SPb.: 2000. P. 163-187.
- Hoffman of V.V. Dysbacteriosis condition of mucous membrane of palatal almonds as local manifestation of microecological system imbalance ? the main reason for developing chronic tonsillitis (analytical review) // Russian otorhinolaryngology. 2014. № 4 (71). P. 32-38.
- Hoffman V.V., Pluzhnikov N.N. New presentation of etiopathogenesis for chronic tonsillitis // Russian otorhinolaryngology. 2014. № 3 (70). P. 34-39.
- Grinchuk O.N. Effectiveness of systemic antibacterial therapy in patients with chronic tonsillitis of streptococcal etiology // Russian otorhinolaryngology. 2011. № 1. P. 50-56.
- Dyomin M.S. Contents of metabolites from lipophilic fraction of echinacea purple fruits // Biological, medical and pharmaceutical chemistry questions. 2010. № 5. P. 52-56.
- Denisenko Yu.O., Andreyeva I.N., Denisenko O. N., Fedorova E.P., Chelova L.V. Influence of the method used to produce extracts from echinacea purple herb on the structure of hydroxycinnamic acids // Current problems of science and education. 2011. № 6; URL: www.science-education.ru/100-5281 (date of circulation: 02.02.2015).
- Drozdova M.V. Assessment of local immunodulatory effects of imudon when used against chronic tonsillitis in children / Treatment and prevention of inflammatory diseases affecting mucous membranes of oral cavity and throat for children. M.: 2002. P. 41-45.
- Dubinskaya G.M., Pochernyaeva V.F., Bobyrev V.N., Samorodov V.N., Pospelov S.V. Erotkan - Medicines from echinacea purple for treatment of stomatologic diseases // Studying and use of echinacea: International scientific conference. Poltava. 1998. P. 122-125.
- Dikov L.A. Some effects of probiotic therapy in chronic tonsillitis // Vyatka medical messenger. 2008. №2. P. 58-61.
- Zabirov R.A. Complex treatment of chronic tonsillitis using sporobakterin // Russian otorhinolaryngology. 2011. № 4. P. 72.
- Zagumennikov V.B. Study of contents and humidity in fresh Echinacea purple herbs // Chemical and pharmaceutical magazine. 2012. № 10. P. 26-28.
- Study of contents of biologically active substances in dry extracts of echinacea narrow-leaved and salvia medicinal // Chemistry of plant raw materials. 2012. №1. P. 153-160.
- Korsun V., Korsun E. Echinacea medications in clinical practice // Doctor. 2008. № 2. P. 71-73.
- Kosenko I.M. Local immunocorrective therapy in tonsillitis and pharyngititis in children // Russian otorhinolaryngology. 2010. № 5. P. 107-116.
- Kochetkov P.A. Treatment of chronic tonsillitis with application of low-frequency ultrasound // News otorhinolaryngology logopathology. 1998. № 1(13). P. 68-69.
- Krepkova L.V., Bortnikova V.V., Borovkov M.V., Sokolskaya T.A.Preclinical toxicological research of phytomedications from echinacea purple herb // Problems of biological, medical and pharmaceutical chemistry. 2012. № 1. P. 178-184.
- Krepkova L.V., Bortnikova V.V., Semkin O.A., Sokolskaya T.A., Okhotnikova V.F. Studying of common toxic and local irritation effects of eucalimin in drug dosage forms - gel and cream // The chemistry-pharmaceutical journal. 2006. V. 40. № 7. P. 35-36.
- Krutikova N.M., Vichkanov S.A., Lipchansky T.Ya. Study of bacteriostatic activities of eucalimin in relation to antibiotic resistence of Streptococcus pneumonia strains // 2nd Russian national congress «Human and Medicine». Tez. abstract. Moscow. 1995. P. 237.
- Krutikova N.M. Eucalimin - a new herbial medicine with antibacterial actions // Phd thesis abstract - biological sciences. 1997. P. 2-28.
- Hooks A.I., Tsarapkin G. Yu., Gorovaya E.V\'s. Application of NO: YAG laser in surgical treatment of chronic tonsillitis // Medical council. 2013. № 2. P. 51-53.
- Kurkin V.A. basis of phytotherapy. Samara. 2009. P.205-207.
- Kurkin V.A. Development of techniques for analysing syrups from echinacea purple // Pharmacy. 2011. № 7. P. 10-12.
- Kurkin V.A., Avdeeva O.I., Avdeeva E.V., Mizina P.G. Total quantitative analysis of hydroxycinnamic acids in aboveground part of Echinacea purpurea (L.) Moench herbs//Plant resources. 1998. V. 34.Issue 2. P. 81-85.
- Lovkova M.Ya., Rabinovich A.M., Ponomareva S.M., Buzuk G.N., Sokolov S.M. Why plants treat. Moscow. 2012. Issue 2. P. 236-238.
- Luchikhin L.A., Malchenko O.V. Effectiveness of «Imudon» in treatment of patients with acut and chronic diseases of a throat // Messenger of otorhinolaryngology. 2001. № 3. P. 62-64.
- Mamchur F.І., Zuzuk B.M., Vasilishin A.A. Chemical contents and pharmacological properties of Echinacea (Asteraceae) // Pharmaceutical journal. 1993. № 2. P. 38-40.
- Ovchinnikov I.A., Klimova L.A., Shekhter A.B. Clinical trial using intralacunar exposure to surgical NIAG-laser beam in treatment of patients with chronic tonsillitis // Messenger of otorhinolaryngology. 2002. №6. P. 37-39.
- Pluzhnikov M.S., Lavrenova G.V. Chronic tonsillitis. Clinic and immunological aspects. 2nd issue. SPb.: Dialogue. 2010. P. 224.
- Pluzhnikov M.S., Lavrenova G.V., Katinas N.B. Immunotropic therapy in the ENT-practice // The reference book on immunotherapy under the editorship of Simbirtsev A.S. SPb., 2002. P. 392 - 401.
- Pluzhnikov M.S., Levin M.Ya., Atnasheva R.R. Oral cavity-s local immunity indicarors in chronic decompensated tonsillitis in combination with different forms of pharyngitis // Russian otorhinolaryngology. 2003. № 2. P. 176-180.
- Rabinovich A.M. Medicinal plants in Russia. Moscow. 2009. P. 404-411.
- Patent Russian Federation 2032414. Method of making medicines from eucalimin / A.A. Savina, N.S. Tsybulko, V.I. Glyzin at al. Issued.10.04.1995.
- Sakanyan K.M., Sokolskaya T.A., Voskoboynikova I.V. current excipients used with phytogenesis components in production of firm dosage forms // Problems of biological, medical and pharmaceutical chemistry. 2014. № 2. P. 23-25.
- Sakovich G.S., Kolkhir V.K., Sokolskaya T.A., Voskoboynikova I.V. Results of clinical trials of medications and components of echinacea, results on safety, possible side effects, interactions with other medicines // Problems of biological, medical and pharmaceutical chemistry. 2010. № 4. P. 11-19.
- Samorodov B.H., Pospelov S.V., Moiseyeva G.F. And others. Phytochemical contents and pharmacological properties (review) of representatives from genius echinacea (Echinacea Moench.) // Chemical-pharmaceutical journal. 1996. V. 30. № 4. P. 32-37.
- Saushkina A.S., Karpenko V.A., Fedorova E.P., Denisenko O.N.Development of methods for analysing suppositories containing echinaea extracts // Regional confrence on pharmaceutical and pharmacological materials. Pyatigorsk: PGFA. 2004. P. 213-214.
- Semkina O.A. Development of contents and technology of soft dosage forms eucalimin. Abstract from Phd thesis ?..pharmaceutical sciences. Moscow. 2005. P. 25.
- Semkina O.A., Sokolskaya T.A., Krasnyuk I.I., Okhotnikova V.F., Krutikova N.M., Vichkanov S.A. Phytomedicine from eucalimin with antimicrobical and anti-inflammatory action // Chemical - pharmaceutical journal. 2006. V. 40. № 8. P. 52-56.
- Skripkin Yu.K. External application of aucalimin in pediatric practice // Pediatrics. 1989. P. 97-99.
- Tarasova G.D., Krutikova N.M., Baked F.F., Vichkanov S.A.Trial using eucalimin in acute inflammatory diseases affecting ENT organs - in children // Messenger for otorhinolaryngology. 1998. № 6. P. 48-50.
- Feklisova L.V., Meskina E.R., Galkin L.A., Tselipanov E.E., Savitskaya N.A., Kazakova S.P. Current approaches to correcting microbiocenosis of oral cavity // Attending physician. 2009. № 10. P. 1-3.
- Horoshilova N. Use of Echinacea medicinese in patients with frequent and chronic respiratory infections // Doctor. 2014. № 3. P. 40-42.
- Tsvetkova O. Use of Immunal in prophylaxis of acute respiratory virus infections and common flu // Doctor. 2007. № 12. P. 48-49.
- Chistik T. Role of phytotherapy in complex treatment of chronic tonsillitis and pharyngitis // News of medicine and pharmacy. 2013. № 5(449). P. 9.
- Chorbinskaya S., Devyatkin A., Vasilyev A. Nonspecific prophylaxis of acute respiratory virus infection in family medicine practice using Echinacea medications // Doctor. 2009. № 10. P. 38-41.
- Shulpekova Yu.A. Inflammatory diseases of an oral cavity and throat // Medicines used in medical emergencies. 2007. № 4. P. 11.
- Ecalimin (Eucaliminum) / http://farmaspravka.com/evkalimin -eucaliminum (date of circulation 12.02.2014).
- Evkalimin (Eucaliminum). Indications to application / http://medprep .info/drug/medicament/2685. (date of circulation 1.03 2014).
- Eucalyptus (Trees and bushes of the Crimea - catalog) / http://poluostrov-krym.com/nashkrym/derevya-kryma/evkalipt.html (date of circulation 21.03. 2014).
- Bames J., Anderson L.A., Gibbons S., Phillipson J.D. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties // J. Pharm. Pharmacol. 2005. V. 57. № 8. P. 929-954.
- Bauer R., Wagner H. Echinacea. Handbuch fur Arzte, Apotheker und andere Naturwisser. Schaftler, Stuttgart. 1990. 182 s.
- Brook I. Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis // Curr. Infect. Dis. Rep. 2013. №15 (3). P. 232-235.
- Cohen R., Levy C., Doit Six-day C. Аmoxicillin vs ten day penicillin V therapy for group A streptococcal tonsillopharyngitis // Pediatr. Infect. Dis. J. 1996. V. 15. P.678-682.
- Huang H., Sun W., Liang Y. Comparative study of bacterial strains and antibiotic susceptibility tests between chronic tonsillitispatients with IgA nephropathy and without nephritis // Ren. Fail. 2013. № 35 (10) P. 1334-1337.
- Javad S.G., Atefeh A.A. Antimicrobial and antifungal properties of the essential oil and methanol extracts of Eucalptus Largiflorens and Eucalyptus Intertexta // Pharmacognosy magazine. 2010. V. 6. № 23. P. 172-175.
- Kothadiya A. A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis // J. Indian Med. Assoc. 2012. № 110 (8). P. 580-583.
- Roberts A.L., Connolly K.L., Kirse D.J. Detection of group A Streptococcus in tonsils from pediatric patients reveals high rate of asymptomatic streptococcal carriage // BMC Pediatr. 2012. V. 12. № 3. P.187-191.
- Ruperto N., Carozzino L., Jamone R. A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians // Ital. J. Pediatr. 2011. V. 37. P. 48.
- Salari M.H., Amine G., Shirazi M.H., Hafezi R., Mohammadypour M. Antibacterial effects of Eucalyptus globules leaf extract on pathogenic bacteriaisolated from specimens of patients with respiratory tract disorders // Clinical microbiology and infection. 2006. V. 12. № 2. P. 194-196.
- Sharma M., Anderson S., Schoop R. Induction of multiple proinflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract // Ant.res. 2009. V. 83. № 2. P. 165-170.
- Sloley B.D., Urichuk L.J., Tywin C., Coutts R.T., Pang P.K., Shan J.J. Comparison of chemical components and antioxidants capacity of different Echinacea species // J. Pharm. Pharmacol. 2001. V. 53. № 6. P. 849-857.
- Takahashi T., Kokubo R., and Sakaino M. Antimicrobial activities of eucalyptus leaf extracts and flavonoids from Eucalyptus maculata // Letters in Applied Microbiology. 2004. V. 39. № 1. P. 60-64.
- http://lekarstwo.ru/preparati/eucaliminum.html (Date of circulation 12.02.2014).
- http://webstatti.com/kompleksnye-gomeopaticheskie-preparaty-v-lechenii-vospalitelnyx-zabolevanij-lor-organov/ (Date of circulation 1.10. 2014).
- www.primamedica.ru/units/otorhinolaryngology(Date of circulation 8.10 2014).