350 руб
Журнал «Вопросы биологической, медицинской и фармацевтической химии» №6 за 2013 г.
Статья в номере:
Холинергическая регуляция иммунных функций
Авторы:
Т.В. Димитриева - студент 5-го курса, кафедра биоорганической химии, биологический факультет, Московский государственный университет им. М.В. Ломоносова
Аннотация:
На клетках иммунной системы были обнаружены все элементы холинергической системы, включая ацетилхолиновые рецепторы (АХР), описаны примеры модуляции иммунных процессов ацетилхолином, его агонистами и антагонистами.
Страницы: 10-12
Список источников

  1. Ishii M., Kurachi Y. Muscarinic acetylcholine raceptors // Current pharmaceutical design. 2006. V. 28 № 12. Р. 3573-3581.
  2. Grutter Th., and Changeux J.-P. Nicotinic receptors in wonderland // Trends in Biochemical Sciences.2001. V. 8. № 26. P. 459-463.
  3. Kawashima K., Kajiyama K., Suzuki T., Fujimoto K. Presence of acetylcholine in blood and its localization in circulating mononuclear leukocytes of humans // Biogenic Amines. 1993. V. 9. P. 251-258.
  4. Koichiro Kawashima and Takeshi Fujii. Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function // Frontiers in Bioscience. 2004. V. 9. P. 2063-2085.
  5. Rosas-Ballina M. et al. T Cells Relay Neural Signals in a Vagus Nerve Circuit // Science. 2011. V. 334. P. 98-101.
  6. Kimura R., Ushiyama N., Fujii F., Kawashima K. Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line // Life Sciences. 2003. V. 72. Р. 2155-2158.
  7. Takeshi Fujii, Koichiro Kawashima. Ca2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor in human T- and B-cell lines // Naunyn-Schmiedeberg-s Archives of Pharmacology. 2000. V. 362. Р. 14-21.
  8. Kamimura Y., Fujii T., Kojima H., Nagano T., Kawashima K. Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line // Life Sciences. 2003. V.72. Р. 2151-2154.
  9. Zimring J.C. Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway // Journal of Neuroimmunology. 2005. V.164 . Р. 66-75.
  10. Mihovilovic M., Butterworth-Robinette J. Thymic epithelial cell line expresses transcripts encoding alpha-3, alpha-5 and beta-4 subunits of acetylcholine receptors, responds to cholinergic agents and expresses choline acetyl transferase. An in vitro system to investigate thymic cholinergic mechanisms // Journal of Neuroimmunology. 2001. V. 117. P. 58-67.
  11. Hao J. Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors // Experimental Neurology. 2011. V. 227. № 1. Р. 110-119.
  12. Westman M., Saha S. , Morshed M., Lampa J.Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity // Clinical and Experimental Immunology. 2010. V. 162. P. 62-67.
  13. Nomura, J., Hosoi T., Okuma Y., Nomura Y.The presence and functions of muscarinic receptors in human T cells:the involvement in IL-2 and IL-2 receptor system // Life Sciences. 2003. V.19. Р.2121-2026.
  14. Albaugh G. Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules,VCAM and ICAM, in endothelial cells in vitro // Annals of vascular surgery. 2004. V. 18. P. 302-307.
  15. Furchgott R.F. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide // JAMA. 1996. V. 276(14). P. 1186-1188.
  16. Skok M.V. Functional Nicotinic Acetylcholine Receptors Are Expressed in B Lymphocyte-Derived Cell Lines // Molecular Pharmacology. 2003. V.64. Р. 885-889.
  17. Skok M., Grailhe R., Agenes F., Changeux J.P. The role of nicotinic receptors in B-lymphocyte development and activation // Life Sciences. 2007. V. 80. P. 2334-2336.
  18. Wang H. et al. Nicotinic acetylcholine receptor a7 subunit is an essential regulator of inflammation // Nature. 2003. V. 421(6921). Р. 384-388.
  19. Wongsriraksa A., Parsons M.E., Whelan C.J. Characterisation of nicotine receptors on human peripheral blood mononuclear cells// Inflammation Research. 2009. V. 58. Р. 38-44.
  20. Bencherif M. et al. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases // Cellular and Molecular Life Sciences. 2011. V. 68. Р. 931-949.
  21. Karimi K., Bienenstock J., Wang L., Forsythe P. The vagus nerve modulates CD4+ T cell activity // Brain, Behavior, and Immunity. 2010. V. 24. Р. 316-323.
  22. Olofsson P.S. et al. α7 nicotinic acetylcholine receptor expression in bone marrow-derived non-T cells is required for the inflammatory reflex // Molecular Medicine. 2012. V. 18. Р.539 - 543.