L.Kh. Pastushkova1, A.G. Goncharova2, D.N. Kashirina3, I.M. Larina4

1–4 State Research Center of the Russian Federation – Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow, Russia)

1 lpastushkova@mail.ru, 2 goncharova.anna@gmail.com, 3 daryakudryavtseva@mail.ru, 4 irina.larina@gmail.com

Space flights have a significant gravitational and radiation impact on the cellular and systemic levels of the body's functions, which leads to many manifestations in the cardiovascular system (CVS). The mechanism of these changes has not been fully characterized. The study of molecular networks involved in the compensation of dysfunctional CVS disorders during long-term space flights using proteomics methods is relevant.

Objective: analysis of molecular networks involved in the compensation of dysfunctional CVS disorders during long-term space flights in "dry spots" of blood.

Contextual analysis of the direction of changes in the concentration of reliably different proteins, in terms of their impact on biological processes, mainly affecting the functional and structural state of blood vessels and the heart, was performed based on the results of visualization of protein-process relationships (ANDvisio program). This made it possible to compile a preliminary version of the biological processes occurring in the body, in which reliably changing proteins participate during space flights.

The practical significance lies in the possibility of using the results to assess the risks of cardiovascular events during long-term space flights.

Pastushkova L.Kh., Goncharova A.G., Kashirina D.N., Larina I.M. Analysis of molecular networks involved in compensation of dysfunctional cardiovascular system´s disorders during long-term space flights in "dry spots" of blood. Technologies of Living Systems. 2025. V. 22. № 3. Р. 5-16. DOI: https://doi.org/10.18127/j20700997-202503-01 (In Russian).

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