O.S. Belik1, V.I. Korchin2

1,2 Khanty-Mansiysk Autonomous Okrug – Ugra “District Clinical Hospital” (Khanty-Mansiysk, Russia)

1 belik.o.s@mail.ru, 2 vikhmgmi@mail.ru

Over the past two decades, the share of the male factor in infertile marriages has increased from 30% to 50%. Despite the fact that many factors have already been established that can lead to male infertility, in 30–60% of patients the etiology of infertility remains unidentified and it is classified as idiopathic. Identification of regional features of the occurrence and pathogenesis of idiopathic male infertility will allow them to be taken into account to select the optimal treatment strategy.

Purpose of the study is to identify the characteristics of the state of oxidative metabolism in patients with idiopathic male infertility living in the northern region.

The work was carried out on the basis of the budgetary institution of the Khanty-Mansiysk Autonomous Okrug – Ugra "District Clinical Hospital" during 2021 – 2023. The main group (I) included 58 patients diagnosed with idiopathic male infertility. The control group (II) was formed from 44 men with realized reproductive function. In the seminal plasma, the concentration of lipid peroxidation products was determined: diene conjugates (DK233) and with thiobarbituric acid - reacting products (TBARS), as well as total antioxidant activity (TAA). The content of lipid hydroperoxides (LPl) and TBARS, as well as indicators of Antioxidant system activity: TAA and thiol status (TS), were detected in the blood serum. The oxidative stress coefficient (OSC) was calculated using the formula: product of LPO products / product of Antioxidant system indicators.

The indicators of LPO and Antioxidant system in the blood serum and ejaculate in patients with idiopathic infertility, compared with men in the control group, underwent significant changes, namely: a significant increase in the concentration of lipid peroxidation products and a decrease in TAA. The integral indicator of oxidative stress (IOS) in the group of infertile men was 4.6 times higher than that in the control group (p <0.001), and also 4.4 times higher than the upper limit of the physiologically acceptable value.

The data obtained during the study on the role of excessive lipid peroxidation in the development of idiopathic infertility in men permanently residing in the North can be used to determine tactics for their treatment and restoration of fertility.

Belik O.S., Korchin V.I. Features of the state of oxidative metabolism in patients with idiopathic male infertility living in the northern region. Technologies of Living Systems. 2024. V. 21. № 4. Р. 54-62. DOI: https://doi.org/10.18127/j20700997-202404-06 (In Russian).

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