A.G. Goncharova1, G.A. Tikhonova2, I.N. Goncharov3, A.A. Markin4

1–4 Federal State Budgetary Institution of Science State Scientific Center of the Russian Federation –
Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow, Russia)

1 goncharova.anna@gmail.com, 2 gtikhonova@imbp.ru, 3 igorgoncharov@gmail.com, 4 andre_markine@mail.ru

The widespread occurrence of food allergies and food intolerance is one of the most significant problems of modern medicine. The urgency of the problem is associated with an increase in the frequency of occurrence of this pathology associated with the peculiarities of nutrition, the emergence of new technologies for processing and preserving products, the introduction of insufficiently studied components into the diet.

The purpose of the work – to systematize the literature data on the problems of clinical control of food allergies and food intolerance.

The review covers the main classifications of allergic reactions, controversial issues of traditional and innovative diagnostics, and the aim is prevention severe forms of allergic diseases and food intolerance.

Prevention of food allergies and food intolerance reduces the economic burden on the healthcare system, improves the quality of life of patients, providing a favorable social and psychological climate.

Goncharova A.G., Tikhonova G.A., Goncharov I.N., Markin A.A. Food allergy and food intolerance. Problems of clinical control (literature review). Technologies of Living Systems. 2023. V. 20. № 4. Р. 80-92. DOI: https://doi.org/10.18127/j20700997-202304-08 (In Russian).

1. EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy. Allergy. 2014. V. 69. № 8. P. 276.
2. Government of Western Australia WA Country Health Service. WACHS Food Allergy Guideline. 2020. https://wacountry.health.wa.gov.au/~/media/WACHS/Documents/About-us/Policies/Food-Allergy-Guideline.pdf?thn=0. Дата обращения: 28.06.2022.
3. Klinicheskiye rekomendatsii. Pishchevaya allergiya. Soyuz pediatrov Rossii. M. 2018. 50 s. (in Russian).
4. Tikhonova G.A., Goncharova A.G., Markin A.A. Allergicheskiye zabolevaniya kak kriteriy professionalnogo otbora kosmonavtov i ispytateley dobrovoltsev. Tekhnologii zhivykh sistem. 2019. № 4. S. 46–52. (in Russian).
5. Japanese guidelines for allergy, 2017. https://pubmed.ncbi.nlm.nih.gov/28285847/. 28.06.2022. Complementary Feeding: a position paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 2017. V. 64. № 1. P. 119–132. http://doi.org/10.1097/MPG.0000000000001454. 28.06.2022.
6. Guidelines for the in the United States: report of the NIAID-Sponsored Expert Panel. J. Allergy Clin. Immunol. 2010. V. 126. P. 6
7. de Silva D., Singh C., Muraro A., Roberts G. European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines Group. Diagnosing, managing and preventing anaphylaxis: Systematic review. Allergy. 2021. V. 76. № 5. Р. 1493–1506.
8. Sicherer S.H., Sampson H.A. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J. Allergy ClinImmunol. 2018. V. 141. № 1. P. 41–58.
9. Sampson H., Aceves S., Bock A. et al. Food allergy: a practice parameter update – 2014. J. Allergy Clin. Immunol. 2014. V. 134. № 5. Р. 1016–1025.
10. Boyce J.A., Assa’ad A., Burks A.W. et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-Sponsored Expert Panel. Nutr. Res. 2011. V. 31. № 1. Р. 61–75.
11. Revyakina V.A. Problema pishchevoy allergii na sovremennom etape. Voprosy pitaniya. 2020. T. 89. № 4. S. 86–192. (in Russian).
12. Kolkhir P.V., Luss L.V., Andreyev I.V. i dr. Pishchevyye allergeny: klassifikatsiya i kharakteristika. Fiziologiya i patologiya immunnoy sistemy. 2005. T. 10. S. 3–33. (in Russian).
13. Pishchevaya allergiya. Ser. Bolezni detskogo vozrasta ot A do Ya. Pod red. A.A. Baranova. L.S. Namazovoy-Baranovoy. T.E. Borovik. S.G. Makarovoy. M.: Pediatr. 2013. 159 s. (in Russian).
14. Prescott S., Allen K.J. Food allergy: riding the second wave of allergy epidemic. Pediatr. Allergy & Immunology. 2011. V. 22. № 1. Р. 156–160.
15. Allergologiya i immunologiya: Natsionalnoye rukovodstvo. Pod red. akademika RAN i RAMN R.M. Khaitova. prof. N.I. Ilinoy. M.: Izd. gruppa GEOTAR-Media. 2014. 656 s. (in Russian).
16. Turnbull J., Adams H., Gorard D. The Diagnosis and management of food allergy and food intolerances. Aliment. Pharmacol. Ther. 2015. V. 41. P. 3–25.
17. Valenta R., Kraft D. Type1 allergic reactions to plant derived food: a consequence of primary sensitization topollen allergens. J. Allergy ClinImmunol. 2009. V. 97. № 4. P. 893–895.
18. Ruffner M.A., Spergel J.M. Eosinophilic esophagitis in children. Curr. Allergy Asthma Rep. 2017. V. 17. № 8. P. 54.
19. Wolf R., Orion E., Ruocco V. et al. Patch testing facts and contradictions. Clinical Dermatol. 2013. V. 31. № 4. P. 479–486.
20. Sidorovich O.I., Luss L.V. Pishchevaya allergiya. Printsipy diagnostiki i lecheniya. Meditsinskiy sovet. 2016. № 16. S. 141–147. (in Russian).
21. Akuete K., Guffey D., Israelsen R.B. et al. Multicenter prevalence of anaphylaxis in clinic-based oral food challenges. Ann. Allergy Asthma Immunol. 2017. V. 119. № 4. P. 339–348.
22. Luss L.V. Pishchevyye allergeny i pishchevyye dobavki: rol v formirovanii pishchevoy allergii i pishchevoy neperenosimosti. Effektivnaya farmakoterapiya. 2014. № 33. S. 12–19. (in Russian).
23. Reznikov Yu.P., Maslennikov V.V., Polyakova V.I., Ignatyeva G.A. Allergomonitorirovaniye in vitro: k otsenke chuvstvitelnosti metodov. Immunologiya. 2015. T. 36. № 2. S. 104–106. (in Russian).
24. Dzhin Kuk Kim. Eo-Min Yun. Von-Dzhong Dzhang i dr. Sravnitelnyy analiz allergotestov MAST-CLA i OPTIGEN. Prakticheskaya meditsina. 2016. T. 3. № 95. S. 125–131. (in Russian).
25. Konsensus WAO-ARIA-GA2LEN po molekulyarnoy diagnostike allergii. Allergologiya i immunologiya. 2014. T. 15. № 1. S. 6–17. (in Russian).
26. Sicherer S.H., Sampson H.A. Food Allergy: A review and updated information on epidemiology, pathogenesis, diagnosis, prevention and treatment. J. Allergy Clin. Immunol. 2018. V. 141. № 1. P. 41–58.
27. Nwary B.I., Hickstein L., Panesar S.S. et al. The epidemiology of food allergy in Europe: systematic review and meta-analysis. Food allergy and anaphylaxis guidelines. 2014. Р. 5-22.
28. Munblit D.B., Korsunskiy I.A. Opredeleniye spetsificheskikh IgG-antitel k pishchevym produktam v diagnostike pishchevoy allergii: mif ili realnost?. RMZh. 2016. № 18. S. 1206–1209. (in Russian).
29. Bock S.A. AAAAI support of the EAACI Position Paper on IgG4. J. Allergy Clin. Immunol. 2010. V. 125. № 6. Р. 1410.
30. Stapel S.O., Asero R., Ballmer-Weber B.K. et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy. 2008. V. 63. № 7. Р. 793–796.
31. Petryszyn P., Staniak A., Wolosianska A., Ekk-Cierniakowski P., Faecal calprotectin as a diagnostic marker of inflammatory bowel disease in patients with gastrointestinal symptoms: meta-analysis. European Journal of Gastroenterology &Hepatology. 2019. V. 31. Р. 1306–1312.
32. Ridolo E., Melli V., Angelis G., Martignago I. Eosinophilic disorders of the gastro-intestinal tract: an update. Clin. Mol. Allergy. 2016. V. 14. P. 17.
33. Yao F., Zhao C., Zhong F., Qin T., Li S., Liu J., Huang B., Wang X. Bioinformatics analysis and identification of hub genes and immune-related molecular mechanisms in chronic myeloid leukemia. Peer J. January. 2022. V. 10. №1. P. e12616.
34. Wechsler M.M., Ackerman A., Drake S., Jackson M., Wardlaw D., Dougan A., Berdnikovs S., Schleich S., Matucci F., Chanez A., Prazma P., Howarth C., Weller P., Merkel P. Eosinophils in Health and Disease: A State-of-the-Art Review. Mayo Clinic Proceedings. 2021. V. 96. Doi: 10.1016/j.mayocp. 2021.04.025
35. Wada T., Toma T., Muraoka M., Matsuda Y., Yachic A. Elevation of fecal eosinophil‐derived neurotoxin in infants with food protein‐induced enterocolitis syndrome. Pediatric Allergy and Immunology. 2014. V. 25 (6). P. 617–619.
36. Rosenberg H.F. Eosinophil-derived neurotoxin. RNase 2: connecting the past, the present and the future. Curr. Pharm. Biotechnol. 2008. V. 9. № 3. Р. 135–140.
37. Rycyk A., Cudowska B., Lebensztejn D.M. Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in Infants. Journal of Clinical Medicine. 2020. V. 9. № 10. Р. 3147.
38. Johansson O., Liang Y., Marcusson J.A., Reimert C.M. Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigonodularis. Arch. Dermatol. Res. 2000. V. 292. № 8. Р. 371–378.
39. Federalnyye klinicheskiye rekomendatsii po okazaniyu meditsinskoy pomoshchi detyam s allergiyey k belkam korovyego moloka. Pod red. A.A. Baranova. L.S. Namazovoy-Baranovoy. R.M. Khaitova i dr. M.: Meditsina. 2022. 463 s. (in Russian).
40. Reglament Evropeyskogo parlamenta i Soveta 1169/2011/EU ot 25 oktyabrya 2011 g. Dostupno po: https://epass.by/TSD/TSD_provider.jsp?ysclid=l3sresikqr. Data obrashcheniya: 28.06.2022 (in Russian).
41. Zakon o markirovke pishchevykh allergenov i zashchite potrebiteley 2004 goda (PDF). Zhurnal Amerikanskoy diyeticheskoy assotsiatsii. T. 106. № 11. S. 1742–1744. (in Russian).
42. TR TS 022/2011 «Pishchevaya produktsiya v chasti eye markirovki». 29 str.; utverzhden Resheniyem Komissii Tamozhennogo soyuza ot 09.12.2011 № 881 (s izmeneniyami na 14 sentyabrya 2018 goda) (in Russian).
43. TR TS 022/2011№ 3 ot 18.02.2021. g. Minsk. S. 1–9. (in Russian).