G.A. Tikhonova1, O.V. Kotov2, A.A. Markin3

1–3 Federal State Budgetary Institution of Science State Scientific Center of the Russian Federation –
Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow, Russian)

3 andre_markine@mail.ru

A feature of the current stage of development of biomedical science is the emergence of new high-precision research methods, which cause a breakthrough in molecular and genetic technologies, contributing to the development of fierce competition both in the scientific and financial fields. Of particular importance in this regard is not only the development and application of new technological techniques, but also ways to protect bioinformation, as well as the development of international and local legislation on aspects of the use of biomedical technologies and biomaterials. Systematization of data on high-precision research methods and their role in the identification of biomarkers, issues of validation and statistical processing of research results using biomarkers, legal and moral aspects of the use of biomedical technologies and biomaterial. The whole set of high-precision analytical technologies is shown, the prospects of their use in the creation of new types of biomarkers are considered, the characteristics and limits of applicability of research methods related to these technologies are discussed. The data presented in the review can serve as a basis for planning biomedical, clinical and pharmacological studies, as well as serve as a basis for bioethical evaluation of the experiments conducted.

Tikhonova G.A., Kotov O.V., Markin A.A. Biomarkers in the practice of biology and medicine (Literature review. Part 2). Technologies of Living Systems. 2023. V. 20. № 4. Р. 5-18. DOI: https://doi.org/10.18127/j20700997-202304-01 (In Russian).

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