350 rub
Journal Technologies of Living Systems №10 for 2012 г.
Article in number:
Modulating effect of the afobazole on the action potentials in the guinea pig primary afferent neurons under the action of 5-hydroxytryptamine
Keywords: afobazole 5-hydroxytryptamine neuron action potential
Authors:
Yu.A. Tolkunov, Yu.D. Ignatov
Abstract:
It is shown that the anxiolytic afobazole in increasing concentrations (1×10?10 - 1×10?5 mol/l) progressively decreased the amplitude of action potentials in primary afferent neurons of the guinea pig small intestine in response to the application of serotonin (1×10?7 mol/l). Introduction of afobazole inside primary afferent neurons through a glass microelectrode outlet does not lead to the blocking action potentials or changes in its individual phases. Afobazole (at the extracellular application) has a modulating effect on the action potentials under the influence of 5-hydroxytryptamine in the primary afferent neurons.
Pages: 43-48
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