O.A. Lopatina - Ph.D. (Med.), Leading Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru E.I. Isaeva - Ph.D. (Biol.), Leading Research Scientist, Laboratory of Immunology, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: immunol.lab@mail.ru I.A. Suetina - Ph.D. (Biol.), Leading Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru O.V. Baklanova - Ph.D. (Biol.), Chief Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru L.I. Russu - Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail:cells@rambler.ru T.N. Pritchina - Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru S.A. Kovalevskii - Dr.Sc. (Phys.-Math.), Laboratory of Chemical Physics of Nanostructures, Institute of Chemical Physics n.a. N.N. Semenov of Russian Academy of Sciences, Moscow. E-mail: icp@chph.ras.ru F.I. Dalidchik - Dr.Sc. (Phys.-Math.), Professor, Head of Laboratory of Theoretical Problems of Chemical Nanophysics, Institute of Chemical Physics n.a. N.N. Semenov of Russian Academy of Sciences, Moscow. E-mail: gomfgal@mail.ru M.V. Mezentseva - Dr.Sc. (Biol.), Head of Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology, Ministry of health of the Russian Federation, Moscow. E-mail: marmez@mail.ru

Influenza viruses are the most common among acute respiratory viral infections. High incidence of the disease at seasonal pickup and epidemies, a high percentage of complications, virus variety, rapid drug resistance appearance induce to generate new antiviral agents. POMs could be perspective in this point and could be used in antiviral drug formula. Antiviral effects of POMs are studied extensively nowadays. Among large amount of different POMs, heteropoly acids with Keggin structure are the most chemically investigated POM. Keggin polyoxometalates were investigated in this work. Keggin POM-s influence on hemagglutinating and infectious activity of different influenza strains (influenza А/Aichi/1/68(Н3N2), А/California/07/09/(Н1N1) и А/Pert16/09(Н3N2)) was investigated. The most virucidal effect on investigated strains was observed after exposure of Keggin POMs with H4SiW12O40 and H4SiMo12O40. POMs effect on cytokines synthesis was investigated. A wide spectrum of cytokine mRNA activities after POM exposure was examined in cells culture HEF. It was demonstrated that, Keggin-s heteropoly acids activated gene transcription of INF-γ, IL-18, IL-1β, IL-8, TNF-α, which played an important role in antiviral immunity. As a result, cytokines in vivo promote macrophage and cellular components of immune system and play an important role in infectious diseases. Investigation of POMs action mechanism could promote the development of drugs, based on POM.

 

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