350 rub
Journal Nanotechnology : the development , application - XXI Century №4 for 2014 г.
Article in number:
Nanoparticle based drugs in clinical practice: achievements and prospects
Keywords: nanoparticle liposome colloidal system bioavailability biocompatibility
Authors:
N.V. Rukosueva - Assistent, Lomonosov Moscow State University of Fine Chemical Technologes. E-mail: nata1i@list.ru D.A. Bezrukov - Ph.D. (Chem.), Lomonosov Moscow State University of Fine Chemical Technologes. E-mail: biotech@list.ru A.P. Kaplun - Dr.Sc. (Chem.), Professor, Lomonosov Moscow State University of Fine Chemical Technologes. E-mail: alexander.p.kaplun@gmail.com V.I. Shvets - Dr.Sc. (Chem.), Academician RAS, Professor, Lomonosov Moscow State University of Fine Chemical Technologes. E-mail: bt@mitht.ru
Abstract:
Most of the currently known drugs have several drawbacks that limit their use in clinical practice. The low solubility in aqueous environments, toxicity, loss of stability when introduced into the body, circulation of a short time, poor pharmacokinetics and unselective distribution can lead to several undesirable effects (loss of optimum therapeutic activity, dose-dependent effects ets.). One way of improving existing drugs is the conclusion of the active substance in a certain shell. Today there is a wide range of the supramolecular structures used as carriers of drug substances, including liposomes, mixed micelles, emulsions, polymer, ceramic and solid lipid nanoparticles, dendrimers, and cyclodextrins. This review is focused on clinically used nanopartically based drugs and drugs in various stages of clinical trials. Particular attention is paid to technologies producing encapsulated forms.
Pages: 18-37
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