N.T. Saliya – Dr. Sc. (Med.), Senior Research Scientist, A.N. Bakulev National Scientific and Practical Center for CVS (Moscow) E-mail: natsalia@mail.ru
O.L. Bokeriya – Corresponding Member of RAS, Dr. Sc. (Med.), Professor, Main Research Scientist, A.N. Bakulev National Scientific and Practical Center for CVS (Moscow)
E-mail: olbockeria@bakulev.ru
D.V. Dzidziguri – Dr. Sc. (Biol.), Professor, Head of Department, Iv. Javakhishvili Tbilisi State University E-mail: diana.dzidzigri@tsu.ge
E.D. Bakuradze – Ph. D. (Biol.), Associate Professor, Iv. Javakhishvili Tbilisi State University
E-mail: Ekaterine.bakuradze@tsu.ge
I.R. Modebadze – Ph. D. (Biol.), Associate Professor, Iv. Javakhishvili Tbilisi State University E-mail: Irina.Modebadze@tsu.ge
The results obtained from the study of molecular mechanisms of the action of low-intensity electromagnetic fields of endogenous origin – endogenous bioresonance therapy (BRT) is presented in this work. It is established that influence of endogenous low intensity electromagnetic fields stimulates cell division in proliferating tissues of experimental animals. In particular, the BRT accelerates the regeneration process by increasing the expression of genes controlling cell division (early response genes). BRT also stimulates cell division in tissues with high proliferative activity in early stage of postnatal development (seven-day rats).
- Deng L., Lin-Lee Y.C., Claret F.X., Kuo M.T. 2-Acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway // J. Biol. Chem. 2001. V. 276. № 1. P. 413−420.
- Fausto N., Campbell J.S., Riehle K.J. Liver regeneration // Hepatology 2006.V. 43. P. 545−553.
- Michalopoulos G.K. Liver regeneration // J. Cell Physiol. 2007. V. 213. № 2. P. 286−300.
- Garbuzenko D.V., Popov G.K. Mexanizmy' regulyaczii regeneraczii pecheni // Ros. Zhurnal gastroe'nterologii, gepatologii, koloproptologii. 2001. T. XI. № 1. S. 21−25.
- Lysenyuk V.P., Samosyuk I.Z., Kulikovich Y.N., Kozhanova A.K. Experimental study on the low-intensity millimeter-wave electromagnetic stimulation of acupuncture points // Acupunct Electrother Res. 2000. V. 25. № 2. P. 91−95.
- Islamov B.I., Balabanova R.M., Funtikov V.A., Gotovskii Y.V., Meizerov E.E. Effect of bioresonance therapy on antioxidant system in lymphocytes in patients with rheumatoid arthritis // Bull Exp. Biol. Med. 2002. V. 134. № 3. P. 248−250.
- Goodman R., Blank M. Insights into electromagnetic interaction mechanisms // J. Cell Physiol. 2002. V. 192. № 1. P. 16−22.
- Lodish H.; Berk A.; Zipursky S.L.; Matsudaira P.; Baltimore D.; Darnell J.E. Molecular Cell Biology. W.H. Freeman and Company. New York. 2000. 1200 p.
- Gotovsky M.U., Perov U.F., Chernetsova L.V. Bioresonance therapy // Edition 2nd. M. Imedis. 2010.
- Chauveau J., Moule Y., Rouiller Ch. Isolation of pure and unaltered liver nuclei: Morfology and Biochemical composition // Exp. Cell Res. 1956. V. 11. P. 317−321.
- Dzidziguri D., Aslamazishvili T., Chkhobadze M., Khorava P., Chigogidze T., Managadze L. The influence of white rat protein factor on transcriptional activity of normal and transformed cells // Proc. Georgian Acad. Sci., Biol. Ser. B. 2004. V. 2. № 1-2. P. 30−35.
- Plexanov G.F. Osnovny'e zakonomernosti nizkochastotnoj e'lektromagnitobiologii. Tomsk: Izd-vo Tomskogo universiteta. 1990. 200 s.
- Frohlich H. Quantum-mechanical concepts in biology // Contributions to physics and biology / Editor M. Marois. Amsterdam: North-Holland. 1969. P. 13.
- Devyatov V.A., Petrov S.V., Laxno V.M., Kulyashov A.I. Dinamika techeniya ranevogo proczessa // Tezisy' itogovy'x rabot «Aktual'ny'e voprosy' rekonstruktivnoj i vosstanovitel'noj xirurgii». Irkutsk. 1991. S. 72−73.
- Devyatov V.A., Petrov S.V. Rezonansny'j e'ffekt – novoe ponyatie v patogeneze ranevogo proczessa. 2002. http://www.sciteclibrary.ru/rus/catalog/pages/3516.html.
- Poslavskij M.V., Dedik Yu.V., Bashkatova V.G. Nekotory'e biofizicheskie aspekty' vliyaniya MM voln na techenie yazvennoj bolezni // «Mediko-biologicheskie aspekty' millimetrovogo izlucheniya» (Sb. pod red. akad. N.D. Devyatkova). M.: IRE' AN SSSR. 1987. S. 21.
- Poslavskij M.V., Shmeleva T.K., Zdanovich O.F. i dr. Millimetrovy'e volny' v mediczine i biologii // Sb. M. IRE' AN SSSR. 1989. S. 43−46.
- Sit'ko S.P., Mkrtchyan L.N. Vvedenie v kvantovuyu mediczinu. Kiev: Pattern. 1994. 145 s.
- Afromeev V.I., Subbotina T.N., Yashin A.A. O vozmozhnom korrelyaczionnom mexanizme aktivaczii sobstvenny'x e'lektromagnitny'x polej kletok organizma pri vneshnem obluchenii // Millimetrovy'e volny' v biologii i mediczine. 1997. № 9-10. S. 28−34.
- Beczkij O.V. S chego vse nachinalos'? // MM volny' v biologii i mediczine. 2005. T. 37. № 1.S. 4−6.
- Zhadin M.N. Review of Russian Literature on Biological Action of DC and Low-Frequency AC Magnetic Fields // Bioelectromagnetics 2001. V. 22. P. 27−45.
- Gerardi G., De Ninno A., Prosdocimi M., Ferrari V., Barbaro F., Mazzariol S., Bernardini D., Talpo G. Effects of electromagnetic fields of low frequency and low intensity on rat metabolism // Biomagn. Res Technol. 2008. Apr 1. 6:3.
- Blackman C.F., Benane S.G., Rabinowitz J.R., House D.E., Joines W.T. A role for the magnetic field in the radiation-induced efflux of calcium ions from brain tissue in vitro // Bioelectromagnetics. 1985. V. 6. P. 327−337.
- Ottani V., De Pasquale, Govoni P., Franchi M., Zaniol P., Ruggeri A. Wounds in the Rat // Bioelectromagnetics. 1988. 9:53−62.
- Athanasiou A., Karkambounas S., Batistatou A., Lykoudis E., Katsaraki A., Kartsiouni T., Papalois A., Evangelou A. The effect of pulsed electromagnetic fields on secondary skin wound healing: an experimental study.// Bioelectromagnetics. 2007. 28:362–8.
- Barzel et al. Electromagnetic Field at 15.95…16 Hz is Cardio Protective Following Acute Myocardial Infarction // Annals of Biomedical Engineering. October 2009. V. 37. № 10. P. 2093−2104.
- Vasil'eva L.K., Gorskij A.N. E'lektrotexnicheskie aspekty' vliyaniya nizkochastotny'x e'lektromagnitny'x polej na cheloveka // Vestn. MANE'B. 2000. № 4. T. 28. S. 31−35.
- Blank M., Goodman R.A. Mechanism for Stimulation of Biosynthesis by Electromagnetic Fields: Charge Transfer in DNA and Base Pair Separation // J. Cell. Physiol. 2008. 214. P. 20−26.
- Zhadin M., Giuliani L. Some problems in modern Bioelectromagnetics // Electromagn. Biol Med. 2006. 25:227−243.
- Tepper O.M., Callaghan M.J., Chang E.I., Galiano R.D., Bhatt K.A., Baharestani S. et al. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 // FASEB J. 2008. № 1. P. 1231−1233.
- Persinger M.A., Koren S.A. A theory of neurophysics and quantum neuroscience: implications for brain function and the limits of consciousness // Int J. Neurosci. 2007. V. 117. P. 157−175.
- Mónica Noemí Jiménez-García, Jaime Arellanes-Robledo, Diana Ivette Aparicio-Bautista, Miguel Ángel Rodriguez-Segura1, Saul Villa-Treviño and Juan José Godina-Nava Jimenez Garcia et al. Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver // BMC Cancer. 2010. 10:159.
- Dzidziguri D.V., Chelidze P.V., Zarandia M.A., Cherkezia E.O., Tumanishvili G.D. The transcriptional activity and ultrastructure of various nucleolar types isolated from normal and partially hepatectomized rat hepatocytes // J. Epith. Cell Biol. 1994. V. 3. P. 240−246.
- Oren M. Toper, Matthew J. Callghan, Edward I. Chang, Robert D. Galiano, Kiri A. Bhatt, Samuel Baharestani, Jean Gan, Bruce Simon, Richard A. Hopper, Jamie P. Levine, Geoffrey C. Gurtner. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 // FASEB J. 2004. Aug; 18(11):1231−1233.
- Tonkonozhenko V.I. i dr. Vliyanie e'lektromagnitny'x kolebanij millimetrovogo diapazona na razvitie e'ksperimental'nogo infarkta miokarda // Sb. nauchny'x rabot «Primenenie mm izlucheniya nizkoj intensivnosti v biologii i mediczina». IRE' AN SSSR. 1985. S. 100−102.
- Eriksson Peter S., Ekaterina Perfilieva, Thomas Björk-Eriksson, Ann-Marie Alborn, Claes Nordborg, Daniel A. Peterson, Fred H. Gage // Neurogenesis in the adult human hippocampus. Nature Medicine. 1998. 4:1313−1317.