M.Yu. Ravaeva1

1 FSAEI HE “V.I. Vernadsky Crimean Federal University” (Simferopol, Russia)
1 ravaevam@yandex.ru

The study is a continuation of a series of papers devoted to the study of the effect of extremely high frequency electromagnetic radiation (EMR EHF) on the microcirculatory processes of rats under stress of varying duration. The hypothesis of the study is that EHF EMR has a vasoprotective effect in modeling ischemia-reperfusion. The hypothesis is based on the results of previous studies that show the vasoprotective effect of EHF EMR under the action of acute and chronic stress and is associated with changes in tissue energy metabolism and microcirculation regulation processes.

The aim is to investigate the effect of low-intensity electromagnetic radiation of extremely high frequency on blood microcirculation in rats when modeling ischemia-reperfusion of the brain.

The microcirculation of the bulbar conjunctiva of rats was analyzed by laser Doppler flowmetry in modeling cerebral ischemia-reperfusion by clamping the common carotid artery after 10-fold preventive EHF exposure.

It was found that preventive 10-fold EHF exposure at the stage of ischemia-reperfusion leads to an increase in total tissue perfusion due to an increase in the metabolic activity of the endothelium, a decrease in sympathetic tone, vasodilation and a decrease in the activity of arteriole myocytes. The use of preventive EHF exposure leads to a reduction in the recovery time of microcirculation in the post-ischemic period.

The results of this study are aimed at solving an important interdisciplinary problem in such fields of science as physiology, biophysics, medicine, rehabilitation – the study of the mechanisms of action of EHF EMR underlying its high biological and therapeutic activity. These studies are relevant because cerebral stroke, according to expert estimates of the World Health Organization, is the second most common cause of mortality, and one of the one of the leading causes of disability of the world's population, and up to 80% of all strokes that occur are of ischemic origin. The high mortality rate in ischemic brain injuries attracts the attention of scientists from various fields of medicine and biology to this problem and makes it urgent to study not only the mechanisms of development of ischemic damage, but also to search for factors preventing the development of this pathology. In our opinion, low-intensity EHF EMR is a highly effective factor limiting the development of this pathological process.

Ravaeva M.Yu. Effects of low-intensity electromagnetic radiation of extremely high frequency in the ischemia-reperfusion model: microcirculatory indicators. Biomedicine Radioengineering. 2025. V. 28. № 7. P. 42–49. DOI: https:// doi.org/10.18127/j15604136-202507-05 (In Russian)

1. Chuyan E.N., Tribrat N.S., Ravaeva M.Yu. i dr. Tkanevaya mikrogemodinamika: vliyanie nizkointensivnogo elektromagnitnogo izlucheniya millimetrovogo diapazona: monografiya. Simferopol': IT «ARIAL». 2017. 422 s. (In Russian).
2. Chuyan E.N., Dzheldubaeva E.R. Nizkointensivnoe millimetrovoe izluchenie: nejroimmunoendokrinnye mekhanizmy adaptacionnyh reakcij. Simferopol': IT «ARIAL». 2020. 622 c. https://www.elibrary.ru/item.asp?id=44136438 (In Russian).
3. Chuyan E.N., Ravaeva M.Yu. Mekhanizmy vazoprotektornogo dejstviya elektromagnitnogo izlucheniya krajne vysokoj chastoty v usloviyah hronicheskogo gipokineticheskogo stressa. Biomedicinskaya radioelektronika. 2017. № 3. S. 55–65 (In Russian).
4. Chuyan E.N., Ravaeva M.Yu. Vliyanie hronicheskogo gipokineticheskogo stressa na tkanevuyu mikrogemodinamiku. Rossijskij fiziologicheskij zhurnal imeni I.M. Sechenova. 2015. T.101. № 3. S. 316–325 (In Russian).
5. Ravaeva M.Yu., Chuyan E.N., Pivovarchuk A.V., Kolesnik V.V. Tkanevaya mikrogemodinamika zhivotnyh v usloviyah ostrogo stressa. Uchenye zapiski Krymskogo federal'nogo universiteta imeni V.I. Vernadskogo Biologiya. Himiya. T.4 (70). 2018. № 3. S. 151–162 (In Russian).
6. Bon' E.I. Sposoby modelirovaniya i morfofunkcional'nye markery ishemii golovnogo mozga. Biomedicina. 2018. № 2. S. 59–71 (In Russian).
7. Lazernaya dopplerovskaya floumetriya mikrocirkulyacii krovi. Pod red. A.I. Krupatkina, V.V. Sidorova: Rukovodstvo dlya vrachej. M.: Medicina. 2005. 256 s. (In Russian).