A.I. Skorobogatova1, A.A. Anisimov2

1,2 St. Petersburg Electrotechnical University “LETI” (St. Petersburg, Russia)
2 Institute of Experimental Medicine (St. Petersburg, Russia)
1 alenskorobogatova@gmail.com, 2 aaanisimov@etu.ru

Prolonged arterial hypertension leads to the development of serious diseases such as heart failure and coronary artery disease. In the absence of pathologies, the baroreflective mechanism is used for short-term and long-term regulation of blood pressure, however, a decrease in baroreceptor sensitivity can lead to chronic sympathetic hyperactivation and, as a result, to the development of hypertension, which, in the absence of proper treatment, can enter a resistive phase. Therefore, early diagnosis of decreased sensitivity of baroreflex can significantly help in preventing the development of hypertension and concomitant cardiovascular diseases.

The aim of the study is to develop an algorithm for assessing the sensitivity of baroreflex, which will help identify early-stage disorders in baroreflex function and, with proper therapy, prevent the development of hypertension. An algorithm for assessing the sensitivity of arterial baroreflex was developed using a regression model and spectral analysis methods, and the algorithm was tested using a database of long-term recordings of electrocardiogram signals, shock values of blood pressure and cardiac output.

The developed algorithm is used in studies of the regulatory mechanisms of central hemodynamics at the Laboratory of Physiology of Bioadministration of the I.P. Pavlov Physiological Department at the Institute of Experimental Medicine, St. Petersburg.

Skorobogatova A.I., Anisimov A.A.. Development of algorithm for assessing baroreflex sensitivity for early diagnosis of hypertension. Biomedicine Radioengineering. 2025. V. 28. № 5. P. 80–84. DOI: https:// doi.org/10.18127/j15604136-202505-16 (In Russian)

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