А.S. Balashova1, L.V. Zhorina2

1,2 Bauman Moscow State Technical University (Moscow, Russia)

2 larisa7777@li.ru

Today, there is an urgent problem of bacterial resistance to antibacterial drugs and the need to develop new methods to combat bacterial skin diseases, including acne of varying severity.

Photodynamic exposure can be a successful alternative to classical treatment, since it allows it to accelerate, eliminate the occurrence of side effects often observed during antibiotic treatment. The purpose of the work is to develop a device for antibacterial (antimicrobial) photodynamic therapy at home.

The paper describes the development and components of the device for antibacterial photodynamic therapy based on the photosensitizer (PS) RadaGel. The device includes a matrix irradiator on LEDs with radiation at wavelengths of 405 and 640 nm which have different penetration depths into the skin and fall into the PS absorption bands. The additional choice of blue light is also due to the fact that it falls into the Sore band of porphyrins produced by the acne-causing bacteria Cutibacterium acnes.

The location of the LEDs for the intensity of skin illumination required for therapy and the exposure time were calculated.

Balashova A.S., Zhorina L.V. Irradiator for antibacterial photodynamic therapy. Biomedicine Radioengineering. 2023. V. 26. № 5. Р. 96-101. DOI: https://doi.org/10.18127/j15604136-202305-10 (In Russian).

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