M.R. Kodenko1, A.N. Arkhangelsky2, A.V. Samorodov3, R.V. Reshetnikov4

1,4 Research and practical clinical center for diagnostics and telemedicine technologies
of the Moscow health care department (Moscow, Russia)

1–3 Bauman Moscow State Technical University (Moscow, Russia)

1 m.r.kodenko@yandex.ru, 2 Ar-han@yandex.ru, 3 avs@bmstu.ru, 4 reshetnikov@fbb.msu.ru

Research in the field of the optimization and improvement of computed tomographic angiography (CTA) methods involves the use of biorelevant physical models of hemodynamics.

The review of current analogues demonstrates their surgical specialization: most devices simulate myocardial function in order to reproduce hemodynamics in the vascular system of a particular patient. The personalization of such models, necessary for preoperative planning, requires accurate reproduction of the vascular system as a whole, which inevitably makes such devices more complex and expensive.

The objective of this study is to create a system, allowing simulation of the pulse blood flow at the particular segment of large vessels for CTA procedure.

The proposed approach allows reproducing flow parameters in a selected vascular segment, simplifying the task of modeling due to the possibility of direct connection of an isolated section of the vascular system. Technical implementation of the device includes: a unit of pulse wave generation with a control board, voltage-frequency converter and recirculation pump; and the test-object representing a model of an extended abdominal aortic segment.

The test-object is made of tissue-imitating materials Dragon skin 30 and TPU 95A reproducing both biomechanical and X-ray properties of the large arterial vessel. Experimental study of the developed system was performed on the Toshiba Aquilion Prime SP scanner with the following parameters: scanning protocol - "body", slice thickness - 1 mm, tube voltage and current - 120 kV and 80 mAs, respectively.

The results obtained during the experimental study of the mockup sample demonstrate the reproducibility of the flow parameters in the physiological frequency range of pulsations 0.5 - 1.5 Hz: 60 - 130 mmHg for pressure and 0.25 - 0.47 m/s for flow velocity. Spearman correlation coefficient between generated and reference pulse wave profile was 0.96. Comparison of X-ray density values of the test object and the injected contrast agent demonstrates normal distribution of data (p-value 0.86 Shapiro-Wilk test) and no statistically significant difference (p-value 0.89 Student's t-criterion); 95% CI for X-ray density of test object material is (112; 125) HU, which agrees well with the published data.

The obtained results can be used for the development and optimization of CTA scanning protocols, as well as for the development of surgical simulators.

Kodenko M.R., Arkhangelsky A.N., Samorodov A.V., Reshetnikov R.V. System for pulse flow simulation in large vessels at CT-angiographic studies. Biomedicine Radioengineering. 2023. V. 26. № 5. Р. 85-95. DOI: https://doi.org/10.18127/j15604136-202305-09 (In Russian).

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