L.H. Pastushkova1, A.G. Goncharova2, D.N. Kashirina3, I.M. Larina4, E.A. Ilyin5

1–5 State Scientific Center of the Russian Federation – Institute of Biomedical Problems of the Russian Academy
of Sciences (Moscow, Russia)

Maintaining high working capacity and health status of persons performing work and living in conditions of hypobaric hypoxia and hypodynamia is an urgent task of physiology and medicine. The study of dynamic changes in the blood proteome gives an understanding of the direction of biological processes of a healthy person's body in extreme conditions. To study the effect of hypobaric hypoxia and hypodynamia on the blood proteome of a healthy person during the annual wintering.

The proteome obtained from "dry" blood spots of 8 practically healthy men was studied by mass spectrometric method. Samples were collected during the wintering year at the Vostok station, every 2 months. Under the influence of a complex of extreme environmental factors, changes in the proteomic composition of blood occur. These changes are clearly compensated, as evidenced by the maintenance of a good state of health and the level of efficiency. The dynamics of proteome parameters in terms of regulation of antioxidant protection, erythrocyte functions as a reflection of adaptation to hypoxia, immunity, elimination of DNA damage by ROS, changes in the activity of angiogenesis, production and transport of sex steroids were noted.

Understanding the direction of biological processes that ensure the adaptation of a healthy organism to a complex of extreme factors is important for the formation of a strategy for medical control and proposals for measures and means of preventing changes in health status.

Pastushkova L.H., Goncharova A.G., Kashirina D.N., Larina I.M., Ilyin E.A. The effect of hypobaric hypoxia on the blood plasma proteome of a healthy person during wintering at the Antarctic Vostok Station. Biomedicine Radioengineering. 2023. V. 26. № 4. P. 5–14. DOI: https:// doi.org/10.18127/j15604136-202302-01 (In Russian)

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