V.A. Yolkin1, A.I. Toma2, V.V. Komarov3, V.P. Meschanov4, P.L. Altukhov5

1 Saratov branch of V.A. Kotel’nikov IRE of RAS (Saratov, Russia)

2 FGBU «United hospital with polyclinic», Administration of the President of Russian Federation (Moscow, Russia)

3 Yuri Gagarin State Technical University of Saratov (Saratov, Russia)

4 JSC NPP «NIKA-SVCH» (Saratov, Russia)

5 Saratov State Law Academy (Saratov, Russia)

Electromagnetic fields of various frequency ranges are widely used in the clinical practice of treatment and diagnosis of many diseases. Along with technologies of high-intensity radiation exposure to pathological biological tissues, for example, ablation and hyperthermia, in modern clinical practice, low-intensity microwave and optical radiation is increasingly used not only for the diagnosis of damaged biological tissues, but also for their treatment. Although the mechanisms of informational interaction of biological tissues with EM fields are still poorly understood, the equipment implementing this interaction is constantly being updated and improved. At the same time, as a rule, devices of this type are highly specialized and are intended either for therapy or for the diagnosis of diseases. The creation of devices and technologies that implement both functions in the treatment process is now becoming very relevant. In this paper, we propose a technology and a device for carrying out a complex effect on the spinal cord lesion area with pulsed electric current, low-intensity laser and EHF (0.1 MW/cm2) radiation to restore its conductor function, reduce pain, stimulate recovery processes. The design of the proposed device assumes the penetration of radiation deep into the biological tissue along the entire length of the damaged area, which, in turn, eliminates the need to move the electro-optical catheter along the damage. Simultaneously with therapy, it is also possible to realize the function of non-disturbing diagnostics of biological tissue.

The paper analyzes the methods of diagnostic and therapeutic use of the proposed device. Such a combined therapeutic and diagnostic system makes it possible to increase the effectiveness of quasi-non-invasive treatment of spinal cord injuries and other biological tissues sensitive to external influences.

Yolkin V.A., Toma A.I., Komarov V.V., Meschanov V.P., Altukhov P.L. Therapeutic and diagnostic technology and device for the restoration of damaged areas of the spinal cord. Biomedicine Radioengineering. 2023. V. 26. № 1. Р. 45-53. DOI: https://doi.org/10.18127/j15604136-202301-05 (In Russian).

1. Petrosyan V.I., Sinitsyn N.I., Elkin V.A., Brill G.E., Razumnik D.A. Lazero-stimulirovannyye radioizlucheniya biotkaney i vodnykh sred. Biomeditsinskaya radioelektronika. 2000. № 2. S. 52–57. (in Russian).
2. Sinitsyn N.I., Elkin V.A., Betskiy O.V. Struktura vodosoderzhashchey sredy biotkaney – osnovopolagayushchiy faktor razvitiya novykh printsipov biomeditsinskikh nanotekhnologiy krayne vysokochastotnogo i teragertsovogo diapazonov. Biomeditsinskaya radio-elektronika. 2013. № 8. S. 16–34. (in Russian).
3. Sinitsyn N.I., Elkin V.A., Gulyayev Yu.V., Betskiy O.V. Meshchanov V.P. Obnaruzheniye lyuminestsentsii plenok biozhidkostey na mikroostriynoy poverkhnosti applikatorov iz naturalnykh mineralov ili iskusstvennykh materialov. Biomeditsinskaya radioelektronika.
   T. 22. №7. 2019. S. 59–65. DOI: 10/18127/j15604136-201907-07 (in Russian).
4. Sinitsyn N.I., Elkin V.A., Betskiy O.V., Molochkov V.A., Suvorov A.P., Suvorov S.A., Gurevich G.I. Novyye printsipy diagnostiki onkologicheskikh zabolevaniy kozhi. Materialy III Vserossiyskoy nauchnoy konferentsii s mezhdunarodnym uchastiyem «Nanotekhnologii v onkologii 2010». 30 oktyabrya 2010. M.: Izd-vo Mosk. nauch.-issled. onkologicheskogo instituta im. P.A. Gertsena. S. 111–114. (in Russian).
5. Patent (RF) na izobreteniye № 2465025 ot 27 oktyabrya 2012 g. Ustroystvo i sposob stimulyatsii spinnogo mozga. A.I. Toma, V.A. Elkin, V.G. Ninel. (in Russian).
6. Toma A.I., Ninel V.G., Abeltsev V.P., Norkin I.A., Toma I.A., Korshunova G.A., Elkin V.A. Vozmozhnosti neyromodulyatsii v stimulyatsii vosstanovitelnykh protsessov u patsiyentov s travmoy pozvonochnika i spinnogo mozga. Kremlevskaya meditsina. Klinicheskiy vestnik. № 4. 2015. S. 101–106. (in Russian).
7. Liu Y., Su J., Lin Z.-J., Teng S., Rhoden A., Pantong N., Liu H. Reconstructions for continuous-wave diffuse optical tomography by a globally convergent method. Journal of Applied Mathematics and Physics. 2014. V. 2(5). P. 204–213. https://doi.org/10.4236/jamp.2014.25025
8. Marques D., Miranda A., Silva A.G., Munro P.R.T., De Beule P.A.A. On the influence of lipid-induced optical anisotropy for the bioimaging of exo- or endocytosis with interference microscopic imaging. J. Microsc. 2018. V. 270(2). P. 150–155.
9. Binzoni T., Martelli F. Study on the mathematical relationship existing between single-photon Laser-Doppler flowmetry and diffuse correlation spectroscopy with static background. J. Opt. Soc. Am A Opt. Image Sci. Vis. 2017. V. 34(12). P. 2096–2101.
10. Bronshteyn I.N., Semendyayev K.A. Spravochnik po matematike dlya inzhenerov i uchashchikhsya vtuzov. SPb.: Lan. 2010. (in Russian).