S.V. Kopylova1, O.A. Sukharevskaya2, A.A. Kazakov3, A.B. Stroganov4, S.V. Semennikova5

1–3 Institute of Biology and Biomedicine of the National Research Lobachevsky State University
of Nizhny Novgorod (Nizhny Novgorod, Russia)

4 Privolzhsky Research Medical University (Nizhny Novgorod, Russia)

5 FBUZ “Privolzhsky District Medical Center” FMBA RF (Nizhny Novgorod, Russia)

Over the past decades, the number of young men who have signs of inflammatory lesions of the prostate has increased significantly. It is believed that one of the mechanisms of the onset of inflammation of the prostate gland is a violation of blood flow in the prostata microcirculatory bed. This leads to stagnation of blood in the venous plexuses of the small pelvis, edema, pelvic pain syndrome. Probably, a special role here belongs to erythrocytes and blood platelets. Therefore, the study of indicators of the morphological and physiological status of platelets and erythrocytes can have diagnostic and prognostic significance, as well as serve as a pathophysiological justification for complex therapy of prostatitis.

Different methods are used to stop the pathology of the prostate gland, including EHF-therapy now. However, although its positive effects in this disease have been shown, the exact mechanism, as well as the timing for which the use of this method of physiotherapy is justified, has not been revealed in the literature available to us.

The aim of this work was to study the possibility of using EHF-therapy to correct the rheological properties of blood in chronic prostatitis in in vitro experiments.

The revealed changes in the functioning of erythrocytes and platelets in in vitro experiments indicate the disruption of adaptive mechanisms in rats with chronic inflammation of the prostate gland. The use of a single EHF-irradiation of blood samples from animals with chronic prostatitis at different stages of the experiment showed that in the early stages of chronic inflammation, extremely high-frequency waves can stabilize the erythrocyte membrane, and at later stages they can only activate adaptive reactions, maintaining cell viability. While at all stages of the inflammatory process, EHF waves change the functional activity of platelets and thereby reduce the adhesion and aggregation of platelets, increasing the retraction of the blood clot.

The results of this work will help substantiate the use of EHF-therapy in chronic inflammation of the prostate gland.

Kopylova S.V., Sukharevskaya O.A., Kazakov A.A., Stroganov A.B., Semennikova S.V. EHF-therapy for correction of rheological properties of blood in chronic prostatitis (experimental in vitro study). Biomedicine Radioengineering. 2022. V. 25. № 2–3. Р. 66-72. DOI: https://doi.org/10.18127/j15604136-202202-07 (In Russian)

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