A.Z. Galiamov – Student, Department “Medical and Technical Information Technologies”, 

Bauman Moscow State Technical University

E-mail: airat.gl@gmail.com

A.A. Zakirova – Resident, Clinic of Oncology, Plastic and Reconstructive Surgery and Radiology,  I.M. Sechenov First Moscow State Medical University

E-mail: albinazakirovasno@gmail.com

I.A. Kudashov – Ph.D. (Eng.), Associate Professor, Department “Medical and Technical Information  Technologies”, Bauman Moscow State Technical University

E-mail: kudashov@bmstu.ru

S.I. Shchukin – Dr. Sc. (Eng.), Professor, Head of Department “Medical and Technical Information Technologies”,  Bauman Moscow State Technical University

E-mail: schookin@mx.bmstu.ru

I.V. Reshetov – Academician of RAS, Dr. Sc. (Med.), Professor, Head of Oncology Center, Clinic of Oncology, Plastic and Reconstructive Surgery and Radiology, I.M. Sechenov First Moscow State Medical University

E-mail: reshetoviv@mail.ru

A.V. Shcherbachev – Post-graduate Student, Department “Medical and Technical Information Technologies”,  Bauman Moscow State Technical University

E-mail: sa0211825@gmail.com

Breast cancer is the most common type of cancer in female population. Surgical removal of the tumor often leads to the breast cancer related lymphedema of the upper limb. Lymphedema lowers quality of life of patients and can lead to severe complications at later stages. Thus, the simple but informative early lymphedema diagnostic method, which can be widely available, is necessary. In this work, a new approach and new parameters are presented for the postmastectomy lymphedema of upper limbs diagnostics with the bioimpedance spectroscopy method.

Objective – study for the possibility of the bioimpedance spectroscopy application in early lymphedema diagnostics, and determination of significant diagnostic parameters.

The data, acquired in the experimental study, confirm the possibility of the lymphedema diagnostics with bioimpedance spectroscopy method. The proposed diagnostic parameter differs significantly between patients and healthy subjects.

The method proposed in this work is based on a measurement of the electrical impedance of the upper limbs in a frequency range from 3 kHz to 349 kHz. The diagnostic parameters are determined with the Cole and Hanai models. Results of the experimental study show the feasibility of the proposed approach. The proposed parameter can be used in biotechnical systems for the lymphedema diagnostics.

1. GCO. Global Cancer Observatory. Breast Fact Sheet. [Elektronnyj resurs] // CANCER TODAY. 2018. URL: http://gco.iarc.fr/today/data/factsheets/cancers/20Breast-fact-sheet.pdf.
2. Ermoshchenkova M.V., Filonenko E.V., Zikiryahodzhaev A.D. Federal'nye klinicheskie rekomendacii po diagnostike i lecheniyu postmastektomicheskogo sindroma // Vestnik vosstanovitel'noj mediciny. 2014. № 5. S. 58–84 (In Russian).
3. Nikolaev D.V. Bioimpedansnyj analiz sostava tela cheloveka. M.: Nauka. 2009. 392 s. (In Russian).
4. Andreuccetti D., Fossi R., Petrucci C. An Internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 Hz – 100 GHz. 1997.
5. De Lorenzo A. et al. Predicting body cell mass with bioimpedance by using theoretical methods: a technological review. Journal of Applied Physiology. 1997 V. 82. № 5. P. 1542–1558.
6. Grimnes S., Martinsen O.G. Bioimpedance and bioelectricity basics. 3rd ed. Boston, MA: Academic Press. 2015.
7. Cole K.S., Cole R.H. Dispersion and Absorption in Dielectrics I. Alternating Current Characteristics. The Journal of Chemical Physics. 1941. V. 9. № 4. P. 341–351.
8. Ayllon D., Seoane F., Gil-Pita R. Cole equation and parameter estimation from electrical bioimpedance spectroscopy measurements – A comparative study. 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Minneapolis, MN: IEEE. 2009. P. 3779–3782.
9. Hanai T. Theory of the dielectric dispersion due to the interfacial polarization and its application to emulsions. Kolloid-Zeitschrift. 1960. V. 171. № 1. P. 23–31.
10. Matthie J.R. Second generation mixture theory equation for estimating intracellular water using bioimpedance spectroscopy. Journal of Applied Physiology. 2005. V. 99. № 2. P. 780–781.
11. Ward L.C., Elia M., Cornish B.H. Potential errors in the application of mixture theory to multifrequency bioelectrical impedance analysis. Physiol. Meas. 1998 V. 19. № 1. P. 53–60.