S.G. Gurzhin – Ph.D. (Eng.), Associate Professor, Department «Information-Measuring and Biomedical 

Engineering», Ryazan State Radio Engineering University n.a. acad. V.F. Utkin; the Winner of the Lenin Komsomol Prize in Science and Technology, Laureate of the Ryazan Region on Science and Technology  and the Silver Medal acad. V.F. Utkin, Honorary Worker of Higher Professional Education  of the Russian Federation (RF)

E-mail: gurzhin@mail.ru

V.I. Zhulev –Dr. Sc. (Eng.), Professor, 

Head of Department «Information-Measuring and Biomedical Engineering» Ryazan State Radio Engineering  University n.a. acad. V.F. Utkin; Laureate of the Ryazan Region on Science and Technology  and the Silver Medal acad. V.F. Utkin, Honored Worker of Higher School of Russian Federation (RF),

E-mail: zhulev.v.i@rsreu.ru

M.B. Kaplan – Ph.D. (Eng.), Associate Professor, Department «Information-measuring and Biomedical  Engineering», Ryazan State Radio Engineering University n.a. acad. V.F. Utkin

E-mail: mik_kap2001@mail.ru

A.V. Shuljakov – Senior Lecturer, Department «Information-measuring and Biomedical Engineering»,  Ryazan State Radio Engineering University n.a. acad. V.F. Utkin

E-mail: shul_andr@mail.ru

M.M. Lapkin – Dr.Sc. (Med.), Professor, Head of the Department «Physiology with the Psychophysiology Course», Ryazan State Medical University n. a. acad. I.P. Pavlov

E-mail: lapkin_rm@mail.ru

A.V. Schulkin – Ph.D. (Eng.), Associate Professor, Department «Pharmacology with a course of pharmacy»,  Ryazan State Medical University. n.a. acad. I.P. Pavlov

E-mail: alekseyshulkin@rambler.ru

E.N. Yakusheva – D.Sc. (Med.), Professor, Head of the Department «Pharmacology with a Course of Pharmacy», Ryazan State Medical University n. a. acad. I.P. Pavlov

E-mail: e.yakusheva@rzgmu.ru

Statement of the problem. The development and implementation of new magnetotherapy equipment in clinical practice requires not only testing its hardware and software and conducting technical tests to confirm operational characteristics and functionality, but also conducting preliminary studies to study the effectiveness of the generated therapeutic magnetic field on a specific type diseases of certain animal systems.

Aim of the work – to conduct preclinical trials of the «RelaxMag» magnetotherapy multisystem and study the effect of lowintensity, low-frequency magnetic fields on the course of aseptic inflammation in laboratory rats.

Results. For the implementation and conduct of preclinical tests, an experimental setup was developed and created, hardware and software adapted by its characteristics and parameters to the test system. Adaptation became possible due to the implementation of new functionalities in the «RelaxMag» multisystem. These include the reconfigurability of software-controlled magnetic module cells in space and time, scalability, i.e. simultaneous recording of code sequences into groups of module cells of cells for the formation of identical magnetic field configurations in a given space and at certain points in time and the virtuality of the control channels of module cells for various therapeutic techniques. The variety of biotropic parameters of the generated magnetic field, the flexibility and accuracy of their task, the correct methods of planning and conducting preclinical studies on animals made it possible to obtain a large amount of objective evidence and make a number of important statements. The main practical result is the pronounced anti-inflammatory effect of the magnetic field generated by the «RelaxMag» experimental unit on the course of aseptic inflammation in laboratory rats.

Practical significance. Studies have confirmed the high level of automation and flexibility of the «RelaxMag» multisystem for the formation of magnetotherapeutic effects, and objective diagnostic monitoring of vital indicators of the test system convincingly testified to the positive effect and anti-inflammatory effect of a low-intensity, low-frequency magnetic field, consistent with cardiac biorhythm. The results obtained will allow the successful implementation of the developed tools and techniques in clinical practice.

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