E.V. Damyanovich
Ph.D. (Med.), Senior Research Scientist, Research center of Neurology (Moscow)
E-mail: damjanov@iitp.ru
L.A. Chigaleychik
Ph.D. (Med.), Senior Research Scientist, Research center of Neurology (Moscow)
E-mail: chigalei4ick.lar@yandex.ru
E.L. Teslenko
Ph.D. (Med.), Research Scientist, Research center of Neurology (Moscow)
E-mail: tes_alena@mail.ru
B.Kh. Baziyan
Sc.D. (Biol.), Head of the Laboratory, Neurocybernetics of Research center of Neurology (Moscow)
E-mail: baz123@yandex.ru

Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood with defined neurobiological substrate. Decease beginning in preschoolers persists in adolescence and even in adulthood [1]. Registration of saccadic eye movements (SEM) is one of the adequate procedures in ADHD objectification. The aim of this study was to analyze ontogenetically persistent SEMs parameters changes in ADHD from childhood to adolescence.

Durations and latencies of saccadic movements recorded in two age groups (7-9 and 10-12 years old) of children and two age groups (13-14 and 15-17 years old) of adolescents were compared. The statistical analysis of data was accomplished by using the nonparametric Mann-Whitney U test (program “Statistica 10”).

The analysis showed no statistically significant age-related changes in saccadic durations and this parameter proved to be the most ontogenetically constant. Saccadic latencies reliably decreased up to 13 years and after this age there were no reliable differences in two adolescent’s groups, so this saccadic parameter remained constantly changed during adolescence.

Functional deficit of brain-stem structures engaged in eye movement conduction proved to be the most ontogenetically constant which resulted in persistent saccadic durations increase. The frontal cortex function gradually improved during maturation till 13 years which resulted in saccadic latencies values, with no changes after this age.

1. Faraone S.V., Biederman J., Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies // Psychol. Med. 2006. V. 36. P. 159–165. http://dx.doi.org/10.1017/S003329170500471X.
2. Damyanovich E.V., Chigalejchik L.A., Teslenko E.L., Baziyan B.H. Vozrastnye izmeneniya parametrov sakkad u detej pri sin-drome deficita vnimaniya s giperaktivnostyu // Biomedicinskaya radioelektronika. 2016. № 4. S. 37–39.
3. Baziyan B.H., Dmitriev I.E. Programmno-apparaturnyj kompleks dlya izucheniya koordinacii dvizhenij glaz, golovy i ruki cheloveka // Zhurnal vysshej nervnoj deyatelnosti. 1996. T. 46. №2. S.396-399.
4. Biederman J., Mick E., Faraone S.V. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type // Am. J. Psychiatry. 2000. V. 157(5). P. 816–818.