G.A. Bilalova
Ph.D. (Biol.), Associate Professor, Department of Human Health, Kazan (Volga Region) Federal University
E-mail: g.bilalova@mai.ru
F.G. Sitdikov
Dr.Sc. (Biol.), Professor, Department of Human Health, Kazan (Volga Region) Federal University
E-mail: fgsitdikov@mail.ru
N.B. Dikopolskaya
Ph.D. (Biol.), Associate Professor, Department of Human Health, Kazan (Volga Region) Federal University
E-mail: bettydn@mail.ru
M.V. Shaykhelislamova
Dr.Sc. (Biol.), Professor, Department of Human Health, Kazan (Volga Region) Federal University
E-mail: kafanatomk@mail.ru

Monoamine dopamine activates D1 and D2 dopamine receptors, which are found in human and rat heart and dopamine interact with α- and β-adrenoceptors. Were conducted in vitro studies on the effect of dopamine at concentrations of 10–9 M to 10–5 M-force reduction of isolated atrial myocardium and ventricular strips rats 56-, 70- and 100-day age when non-selective alpha-adrenergic blockade phentolamine. Isometric contraction of myocardial strips atria and ventricles were recorded on the installation «Power Lab». All experiments were performed in compliance with the bioethical rules.

When α-adrenergic blockade of dopamine at a dose of 10-5 M causes an increase in the atrial myocardium of rats 56-, 70- and 100 days age. On the background of adrenoceptor blockade in 56-day-old rat ventricular myocardial contractility increases, while the 70- and 100-day conversely decreases. Dopamine concentrations 10-6M – 10-8M reduces the force of contraction myocardium as the strips atria, ventricles and rats of all ages studied. Dopamine in the 10-9 M concentration increases myocardial contractility atria and ventricles in 57 and 70-day-old rats. At the 100-day-old animals at this concentration takes place a reliable decrease force of contractility as the atrial myocardium, and the ventricles.

Thus non-selective blockade of the alpha-adrenergic receptors alters the effect of phentolamine dopaminergic rehulation of the heart formed with sympathetic innervation.

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