I.A. Cherenkov
Ph.D. (Biol.), Associate Professor, Department of Anatomy and Physiology of Human and Animals,
Udmurt State University (Izhevsk); Associate Professor, Department of Biology and Ecology, Izhevsk State Medical Academy
E-mail: ivch75@yandex.ru
V. G. Sergeev
Dr. Sc. (Biol.), Professor, Department of Anatomy and Physiology of Human and Animals, Udmurt State University (Izhevsk);
Head of the Educational and Experimental Laboratory, Izhevsk State Medical Academy
E-mail: cellbio@yandex.ru
E.S. Nikitina
Master Student of Program «Cell biology», Udmurt State University (Izhevsk)
E-mail: elenanikitina.94@mail.ru
I. L. Ivanova
Ph.D. (Med.), Associate Professor, Department of Neurology and Medical Genetics, Izhevsk State Medical Academy,
Scientific Adviser of Respublic Center Parkinson Disease and Movement Disorders (Izhevsk)
E-mail: urairiva@yandex.ru

Amperometry at a fixed value of the potential with using electrodes modified with electroactive polymers is the method which allows to monitor redox balance of blood plasma.

The potential of the working electrode (WE) -0,2 V (Ag/AgCl) correspond to negative values of current. Values in the samples of patient with early stages of PD was significantly higher the control ones.

Under peroxide loading condition (E=+0,2 V) a current reduction of oxidation of the polymer in the blood plasma samples of the control group and increase of current values in the plod plasma of patient with PD is observed. The increase of current is most pronounced in the early stages of PD.

When there is potential of the working electrode E=-0,2 V, differences of currents of the polymer reduction is not detected in the control group. However current value in the blood plasma samples of patients with early stage of PD is reduced by almost two times and current in the samples with the late stage of the disease has a distinct tendency to decrease. This work was financially supported by RFBR in grant № 10-04-00246 and The Foundation for Assistance to Small Innovative Enterprises in Science and Technology (the program "UMNIK").

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