N.A. Loginova
 Ph.D. (Biol.), Senior Scientist, Laboratory of Functional Neurocytology,
Institute of Higher Nervous Activity and Neurophysiology RAS (Moscow)
E-mail: nadezhda.loginova1982@gmail.com
E.V. Loseva
Dr.Sc. (Biol.), Chief Scientist, Laboratory of Functional Neurocytology,
Institute of Higher Nervous Activity and Neurophysiology RAS (Moscow)
E-mail: losvnd@mail.ru
N.V. Panov
Assistant, Laboratory of Functional Neurocytology,
Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow)
E-mail: nikolay.panov1966@yandex.ru
V.V. Gavrilov
Ph.D (Psychol.), Senior Scientist, Laboratory of Psychophysiology,
Institute of Psychology RAS (Moscow)
E-mail: nvvgav@mail.ru

In this study we investigated the level of c-fos expression in different brain areas in male and female rats housed in the absence of light with standard immunohistochemical staining protocol. We developed special integrative index for estimation of metabolic activity in brain structures. It was found that early long-term visual deprivation was associated with reduced c-fos expression in different areas of neocortex in male and in different areas of neocortex and some areas of diencephalon and mesencephalon in female rats. The reduced expression of c-fos in different brain areas in rats subjected to long-term visual deprivation from birth to maturity indicates a decline in the activity of these brain regions. Along with data about the decrease in the total thickness of the cortex and the increase of glio-neuronal index, these findings suggest the changing role of these regions in the formation of individual experience.

Supported by RFBR grant №15-06-06925 “Psychophysiological bases of the formation of individual experience under visual deprivation in ontogenesis”

1. Barabanshhikov V.A., Zhegallo A.V. Registracziya i analiz napravlennosti vzora cheloveka. M.: Institut psixologii RAN. 2013.
2. Arutyunova K.R., Gavrilov V.V., Aleksandrov Ju.I. Formirovanie individual'nogo opy'ta v otsutstvie zritel'nogo kontakta so sredoj // Materialy' VI Vseros. nauch.-prakt. konf. «Druzhininskie chteniya». Sochi. 2007. T. I. S. 39–41.
3. Arutyunova K.R., Gavrilov V.V., Aleksandrov Ju.I. Nauchenie i povedenie v otsutstvie zritel'nogo kontakta so sredoj u kry's // E'ksperimental'naya psixologiya. 2014. T. 7. № 3. S. 31–43.
4. Arutyunova K.R., Gavrilov V.V. Obuchenie i povedenie v otsutstvie kontakta s opticheskimi parametrami sredy' u vidov s razny'mi e'kologicheskimi znacheniyami zreniya // V sb. «E'volyuczionnaya i sravnitel'naya psixologiya v Rossii: tradiczii i perspektivy'» / red. A.N.Xaritonov. M.: Institut psixologii RAN. 2013. S. 98–105
5. Nikols Dzh.G., Martin A.R., Vallas B.Dzh., Fuks P.A. Ot nejrona k mozgu. M.: LKI. 2008. 672 s.
6. Loseva E.V., Loginova N.A., Gavrilov V.V. Tolshhina sloev razny'x oblastej neokorteksa u kry's, vy'rosshix v temnote // Biomediczinskaya radioe'lektronika. 2015. № 4. S. 51–53.
7. Loseva E.V., Loginova N.A., Panov N.V., Gavrilov V.V. Reaktivny'j glioz v V sloe razny'x oblastej neokorteksa u kry's, vy'rosshix v temnote. Biomediczinskaya radioe'lektronika. 2016. № 4. S. 73–76.
8. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. Elsevier Academic Press. 2005. 210 p.
9. Loseva E.V., Mezenczeva M.V., Russu L.I., Loginova N.A., Panov N.V., Shhetvin M.N., Suetina I.A. Podavlenie sinteza czitokinov v selezenke i mozge i slaby'e izmeneniya e'kspressii c-fos v mozge kry's pri intranazal'nom vvedenii odnoslojny'x uglerodny'x nanotrubok // Rossijskie nanotexnologii. 2016. T. 11. № 3–4. S. 80–86.
10. Sagar S.M., Sharp F.R., Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level // Science. 1988. V. 240. P. 1328–1331.
11. Figueiredo H.F., Dolgas C.M., Herman J.P. Stress activation of cortex and hippocampus is modulated by sex and stage of estrus // Endocrinology. 2002. V. 143. № 7. P. 2534–2540.