I.P. Butkevich - Dr.Sc. (Biol.), Leading Research Scientist, I.P. Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia. E-mail: irinabutkevich@yandex.ru V.A. Mikhailenko - Ph.D. (Biol.), Senior Research Scientist, I.P. Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia. E-mail: viktormikhailenko@yandex.ru Т.N. Shimaraeva - Ph.D. (Biol.), Associate Professor, Pediatric Medical University, Saint-Petersburg, Russia. E-mail: 3706381@mail.ru

Previously, we reported on the long-term strengthening of pain sensitivity in adult rats exposed in the newborn state to inflammatory pain or stress of separation from the dam and siblings. The aim of this study was to determine the possibility to neutralize the harmful effects of early stress effects in basal pain and in induced inflammatory pain in adult rats. The study was performed on adult male rats exposed during first two days of life to inflammatory pain injury, or stress of separation from the dam, or combination of these impacts and from 25th to 39th postnatal days the rats were exposed to 5-HT1A receptor agonist buspirone injections, control rats, to saline injections. When the rats reached 90 days of age, pain sensitivity was investigated in the hot plate test, in 24 hours, in the formalin test. It was found that buspirone normalized pain sensitivity in adult rats in both tests. The data obtained indicate the protective effect of adolescent buspirone in the adult rats that experienced early life inflammatory pain or stress of separation from the dam and siblings. The study was supported by RFBR project N 14-04-00106a.

 

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