350 rub
Journal Biomedical Radioelectronics №8 for 2015 г.
Article in number:
The non-invasive laser speckle-sensor of blood flow velocity in microvasculature
Authors:
O.F. Lukashova - Post-gradute Student, Department of Quantum Electronics, Institution of Physics, Nanotechnologies and Telecommunications, St. Petersburg Polytechnic University of Peter the Great. E-mail: olga.lukashova.best@gmail.com D.V. Mokrova - Ph.D. (Phys.-Math.), Department of Quantum Electronics, Institution of Physics, Nanotechnologies and Telecommunications, St. Petersburg Polytechnic University of Peter the Great. E-mail: dashkeria@gmail.com E.T. Aksenov - D.Sc. (Phys.-Math.), Department of Quantum Electronics, Institution of Physics, Nanotechnologies and Telecommunications, St. Petersburg Polytechnic University of Peter the Great. E-mail: et.aksenov@gmail.com
Abstract:
The purpose of this study was developing and producing a laboratory model of individual speckle-sensor of blood flow velocity in microvasculature in human-s skin. Topicality of this paper is determined by the necessity of producing an individual sensor allowing well-timed registration of urgent situations in cardiovascular system of a patient. In order to achieve that there were posed the following problems: producing of the sensory part of the sensor; development of the informative signal processing system based on PC. In order to accomplish a task there were discussed and examined various settings-up of sensory part of the sensor: a single-channel set-up, a set-up with two spatially distributed registering photo detectors. Besides there were discussed various methods of informative signal processing: autocorrelation and cross-correlation approaches. The processing of received data was organized using especial computer-based program made by means of LadVIEW. As a result, there was developed and proved the methodology of non-invasive registration of average blood flow velocity in microvasculature based on speckle-interferometry. There was the laboratory model of the speckle-sensor of blood flow velocity in microvasculature produced. Efficiency of the model was demonstrated experimentally on patterns as well as in vivo.
Pages: 70-77
References

 

  1. de Mul F.F.M., van Spijker J., van der Plas D. et al. Mini laser-Dopler (blood) flow monitor with diode laser source and detection integrated in the probe // Applied optics. 1984. V. 23. № 17. P. 2970-2973.
  2. Uljanov S. S. CHto takoe spekly // Sorosovskijj obrazovatelnyjj zhurnal. 1999. № 5. S. 112-116.
  3. Asacura T.,Takai N. Dynamic laser speckles and their application to velocity measurements of diffuse object // Applied Physics. 1981. V. 25. P. 179-194.
  4. Mokrova D.V. Beskontaktnaja diagnostika fizicheskikh parametrov biologicheskikh obektov na osnove opticheskikh spekl-polejj i difraktometrii: Diss. kand. fiz.-mat. nauk. SPb. 2010.
  5. Churnside J.H., Yura H.T.Velocity measurement using laser speckle statistics // J. Applied Optics. 1981. V. 20. № 20. P. 3539-3541.
  6. Fedosov I.V., Tuchin V.V. Registracija dinamiki limfotoka v mikrososudakh s ispolzovaniem korreljacionnykh svojjstv rassejannogo kogerentnogo izluchenija // Kvantovaja ehlektronika. 2002. Vyp. 13. № 11. S. 970-974.
  7. Fedosov I.V., Tuchin V.V. Prostranstvenno-vremennaja korreljacija intensivnosti spekl-polja, sformirovannogo pri rassejanii sfokusirovannogo kogerentnogo izluchenija na kapilljarnom potoke zhidkosti, soderzhashhejj rasseivajushhie chasticy // Optika i spektroskopija. 2002. T. 93. № 3. S. 473-477.
  8. Aizu Y., Asacura T. Coherent optical techniques for diagnostics of retinal blood flow // J. of Biomedical Optics. 1999. V. 4. № 1. P. 61-75.
  9. Rjabukho V.P. Spekl-interferometrija // Sorosovskijj obrazovatelnyjj zhurnal. 2001. T. 7. № 5. C. 102-109.